======= AK3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AK3
  * **<color #00a2e8>Official Name</color>**: adenylate kinase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=50808|50808]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UIJ7|Q9UIJ7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AK3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AK3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609290|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a GTP:ATP phosphotransferase that is found in the mitochondrial matrix. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. {ECO:0000255|HAMAP-Rule:MF_03169, ECO:0000269|PubMed:11485571}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ADK lid|
|ADK|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ITP metabolic process|
|nucleoside triphosphate adenylate kinase activity|
|ADP biosynthetic process|
|purine nucleoside diphosphate biosynthetic process|
|ribonucleoside diphosphate biosynthetic process|
|purine ribonucleoside diphosphate biosynthetic process|
|nucleoside diphosphate biosynthetic process|
|adenylate kinase activity|
|UTP metabolic process|
|nucleoside monophosphate phosphorylation|
|AMP metabolic process|
|pyrimidine ribonucleoside triphosphate metabolic process|
|pyrimidine nucleoside triphosphate metabolic process|
|pyrimidine ribonucleotide metabolic process|
|GTP metabolic process|
|purine ribonucleoside monophosphate metabolic process|
|purine nucleoside monophosphate metabolic process|
|guanosine-containing compound metabolic process|
|ADP metabolic process|
|ribonucleoside monophosphate metabolic process|
|purine ribonucleoside triphosphate metabolic process|
|purine ribonucleoside metabolic process|
|purine nucleoside diphosphate metabolic process|
|pyrimidine nucleotide metabolic process|
|purine ribonucleoside diphosphate metabolic process|
|ribonucleoside diphosphate metabolic process|
|purine nucleoside metabolic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|nucleoside monophosphate metabolic process|
|ribonucleoside metabolic process|
|nucleoside diphosphate metabolic process|
|nucleoside triphosphate metabolic process|
|pyrimidine-containing compound metabolic process|
|nucleoside metabolic process|
|glycosyl compound metabolic process|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|blood coagulation|
|coagulation|
|hemostasis|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|mitochondrial matrix|
|GTP binding|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|wound healing|
|regulation of body fluid levels|
|drug metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|response to wounding|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp224|CB-839 10μM R05 exp224]]|-1.93|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.75|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.71|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.73|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.31|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.5|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|2.66|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufa2|NDUFA2]]|0.459|
|[[:human genes:m:mcat|MCAT]]|0.45|
|[[:human genes:g:gfm2|GFM2]]|0.428|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.419|
|[[:human genes:m:mto1|MTO1]]|0.415|
|[[:human genes:n:ndufa3|NDUFA3]]|0.405|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3282
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AK3 Expression in NALM6 Cells: 5.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>