======= AK4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AK4
  * **<color #00a2e8>Official Name</color>**: adenylate kinase 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=205|205]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P27144|P27144]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AK4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AK4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/103030|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000255|HAMAP-Rule:MF_03170, ECO:0000269|PubMed:19073142, ECO:0000269|PubMed:19766732, ECO:0000269|PubMed:23416111}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ADK|
|ADK lid|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleoside triphosphate adenylate kinase activity|
|nucleoside monophosphate kinase activity|
|ADP biosynthetic process|
|purine ribonucleoside diphosphate biosynthetic process|
|ribonucleoside diphosphate biosynthetic process|
|purine nucleoside diphosphate biosynthetic process|
|nucleoside diphosphate biosynthetic process|
|adenylate kinase activity|
|nucleoside monophosphate phosphorylation|
|AMP metabolic process|
|regulation of ATP biosynthetic process|
|nucleoside diphosphate kinase activity|
|GTP metabolic process|
|nucleobase-containing small molecule interconversion|
|regulation of oxidative phosphorylation|
|purine ribonucleoside monophosphate metabolic process|
|purine nucleoside monophosphate metabolic process|
|regulation of purine nucleotide biosynthetic process|
|regulation of nucleotide biosynthetic process|
|guanosine-containing compound metabolic process|
|ADP metabolic process|
|ribonucleoside monophosphate metabolic process|
|nucleoside diphosphate phosphorylation|
|purine ribonucleoside triphosphate metabolic process|
|purine ribonucleoside metabolic process|
|purine nucleoside diphosphate metabolic process|
|nucleotide phosphorylation|
|purine ribonucleoside diphosphate metabolic process|
|nucleoside triphosphate biosynthetic process|
|ribonucleoside diphosphate metabolic process|
|purine nucleoside metabolic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|nucleoside monophosphate metabolic process|
|ribonucleoside metabolic process|
|nucleoside diphosphate metabolic process|
|nucleoside triphosphate metabolic process|
|nucleoside metabolic process|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|liver development|
|hepaticobiliary system development|
|glycosyl compound metabolic process|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|regulation of generation of precursor metabolites and energy|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|cellular response to hypoxia|
|cellular response to decreased oxygen levels|
|ATP metabolic process|
|cellular response to oxygen levels|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|response to hypoxia|
|response to decreased oxygen levels|
|purine-containing compound metabolic process|
|mitochondrial matrix|
|response to oxygen levels|
|GTP binding|
|gland development|
|regulation of small molecule metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|drug metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|brain development|
|head development|
|organophosphate metabolic process|
|central nervous system development|
|response to drug|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|regulation of phosphorylation|
|cellular nitrogen compound biosynthetic process|
|cellular response to stress|
|small molecule metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3504
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AK4 Expression in NALM6 Cells: 7.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>