======= AK6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AK6
  * **<color #00a2e8>Official Name</color>**: adenylate kinase 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=102157402|102157402]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3D8|Q9Y3D8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AK6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AK6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619357|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation. {ECO:0000269|PubMed:15630091}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleoside monophosphate kinase activity|
|adenylate kinase activity|
|nucleoside monophosphate phosphorylation|
|nucleobase-containing small molecule interconversion|
|Cajal body|
|nucleoside monophosphate metabolic process|
|ATPase activity|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|nucleolus|
|organophosphate metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-2.05|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.89|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.71|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.73|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.74|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.83|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.88|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.9|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.91|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|2.02|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.06|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.15|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.29|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.37|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.93|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|3.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 403/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|16/28|
|blood|8/28|
|bone|14/26|
|breast|10/33|
|central nervous system|41/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|11/13|
|fibroblast|0/1|
|gastric|10/16|
|kidney|14/21|
|liver|9/20|
|lung|39/75|
|lymphocyte|3/16|
|ovary|16/26|
|pancreas|18/24|
|peripheral nervous system|10/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|15/24|
|soft tissue|5/9|
|thyroid|2/2|
|upper aerodigestive|15/22|
|urinary tract|23/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 849
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AK6 Expression in NALM6 Cells: 5.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>