======= AKAP9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AKAP9
  * **<color #00a2e8>Official Name</color>**: A-kinase anchoring protein 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10142|10142]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99996|Q99996]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AKAP9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AKAP9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604001|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. [provided by RefSeq, Aug 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PACT coil coil|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dendritic branch|
|extrinsic component of postsynaptic density membrane|
|maintenance of centrosome location|
|regulation of cardiac muscle cell action potential involved in regulation of contraction|
|regulation of postsynaptic neurotransmitter receptor activity|
|maintenance of organelle location|
|regulation of Golgi organization|
|negative regulation of adenylate cyclase activity|
|microtubule nucleation|
|negative regulation of cyclase activity|
|protein kinase A regulatory subunit binding|
|negative regulation of lyase activity|
|regulation of ventricular cardiac muscle cell membrane repolarization|
|positive regulation of potassium ion transmembrane transporter activity|
|synaptic membrane|
|regulation of cardiac muscle cell membrane repolarization|
|regulation of adenylate cyclase activity|
|regulation of cardiac muscle cell action potential|
|centrosome localization|
|microtubule organizing center localization|
|positive regulation of microtubule polymerization|
|microtubule polymerization|
|regulation of membrane repolarization|
|positive regulation of microtubule polymerization or depolymerization|
|Golgi stack|
|positive regulation of potassium ion transmembrane transport|
|regulation of heart rate by cardiac conduction|
|regulation of cardiac muscle cell contraction|
|potassium channel regulator activity|
|regulation of actin filament-based movement|
|response to electrical stimulus|
|regulation of cyclase activity|
|positive regulation of potassium ion transport|
|regulation of lyase activity|
|molecular adaptor activity|
|regulation of action potential|
|microtubule polymerization or depolymerization|
|regulation of microtubule polymerization|
|cellular response to cAMP|
|regulation of potassium ion transmembrane transporter activity|
|cis-Golgi network|
|regulation of neurotransmitter receptor activity|
|regulation of cardiac muscle contraction|
|regulation of microtubule polymerization or depolymerization|
|regulation of potassium ion transmembrane transport|
|voltage-gated potassium channel complex|
|protein polymerization|
|regulation of striated muscle contraction|
|cardiac conduction|
|maintenance of location in cell|
|ciliary basal body-plasma membrane docking|
|regulation of potassium ion transport|
|regulation of heart rate|
|response to cAMP|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of peptidyl-serine phosphorylation|
|positive regulation of transporter activity|
|ion channel binding|
|positive regulation of protein polymerization|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|multicellular organismal signaling|
|response to organophosphorus|
|regulation of nervous system process|
|regulation of peptidyl-serine phosphorylation|
|positive regulation of cation transmembrane transport|
|response to purine-containing compound|
|positive regulation of ion transmembrane transport|
|regulation of muscle contraction|
|maintenance of location|
|organelle localization by membrane tethering|
|regulation of signaling receptor activity|
|membrane docking|
|regulation of microtubule cytoskeleton organization|
|regulation of G2/M transition of mitotic cell cycle|
|positive regulation of supramolecular fiber organization|
|positive regulation of transmembrane transport|
|regulation of cell cycle G2/M phase transition|
|positive regulation of cytoskeleton organization|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|regulation of muscle system process|
|regulation of heart contraction|
|positive regulation of protein complex assembly|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|mitotic cell cycle phase transition|
|positive regulation of ion transport|
|regulation of transporter activity|
|cell cycle phase transition|
|regulation of blood circulation|
|regulation of cation transmembrane transport|
|signaling receptor binding|
|cilium assembly|
|glutamatergic synapse|
|regulation of supramolecular fiber organization|
|cytoskeleton|
|cilium organization|
|neuronal cell body|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|regulation of mitotic cell cycle phase transition|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|regulation of membrane potential|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|cell projection assembly|
|synaptic signaling|
|microtubule cytoskeleton organization|
|regulation of ion transmembrane transport|
|centrosome|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|cellular response to organic cyclic compound|
|regulation of transmembrane transport|
|organelle localization|
|regulation of system process|
|mitotic cell cycle process|
|cellular response to organonitrogen compound|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|cellular response to nitrogen compound|
|microtubule-based process|
|mitotic cell cycle|
|intracellular membrane-bounded organelle|
|regulation of ion transport|
|regulation of cell cycle process|
|organelle assembly|
|negative regulation of catalytic activity|
|cellular protein-containing complex assembly|
|response to organic cyclic compound|
|regulation of cellular component biogenesis|
|Golgi apparatus|
|positive regulation of transport|
|regulation of cellular component movement|
|cell cycle process|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|cytoskeleton organization|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|cell projection organization|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of organelle organization|
|cell cycle|
|regulation of protein phosphorylation|
|DNA binding|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.99|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.88|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12092
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AKAP9 Expression in NALM6 Cells: 8.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>