======= AKIRIN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AKIRIN2
  * **<color #00a2e8>Official Name</color>**: akirin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55122|55122]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q53H80|Q53H80]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AKIRIN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AKIRIN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615165|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity). {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transcriptional repressor complex|
|positive regulation of interleukin-6 production|
|regulation of interleukin-6 production|
|positive regulation of endopeptidase activity|
|positive regulation of peptidase activity|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|enzyme binding|
|positive regulation of proteolysis|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|embryo development ending in birth or egg hatching|
|response to bacterium|
|regulation of cytokine production|
|regulation of proteolysis|
|innate immune response|
|positive regulation of hydrolase activity|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of cell population proliferation|
|defense response to other organism|
|embryo development|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.97|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.93|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.79|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.73|
|[[:results:exp539|42°C R08 exp539]]|-1.7|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|1.82|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.553|
|[[:human genes:p:polr2j3|POLR2J3]]|0.55|
|[[:human genes:t:tfip11|TFIP11]]|0.548|
|[[:human genes:k:kctd17|KCTD17]]|0.544|
|[[:human genes:l:lrr1|LRR1]]|0.533|
|[[:human genes:n:ndc1|NDC1]]|0.527|
|[[:human genes:t:tceb3c|TCEB3C]]|0.525|
|[[:human genes:r:rbbp5|RBBP5]]|0.521|
|[[:human genes:c:c14orf93|C14orf93]]|0.517|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.513|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.508|
|[[:human genes:p:psma6|PSMA6]]|0.508|
|[[:human genes:s:sf3a3|SF3A3]]|0.503|
|[[:human genes:n:nupl1|NUPL1]]|0.502|
|[[:human genes:d:dtl|DTL]]|0.491|
|[[:human genes:o:orc6|ORC6]]|0.49|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.49|
|[[:human genes:r:rps28|RPS28]]|0.488|
|[[:human genes:v:vasn|VASN]]|0.488|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.485|
|[[:human genes:n:nbpf10|NBPF10]]|0.484|
|[[:human genes:m:med17|MED17]]|0.484|
|[[:human genes:o:orc1|ORC1]]|0.483|
|[[:human genes:p:psmd1|PSMD1]]|0.483|
|[[:human genes:c:copa|COPA]]|0.483|
|[[:human genes:r:rps12|RPS12]]|0.478|
|[[:human genes:i:ik|IK]]|0.477|
|[[:human genes:n:nup54|NUP54]]|0.476|
|[[:human genes:h:hap1|HAP1]]|0.475|
|[[:human genes:r:rbm39|RBM39]]|0.475|
|[[:human genes:c:cdca3|CDCA3]]|0.475|
|[[:human genes:c:cdc73|CDC73]]|0.474|
|[[:human genes:u:ubap1|UBAP1]]|0.474|
|[[:human genes:d:ddtl|DDTL]]|0.473|
|[[:human genes:c:ccdc94|CCDC94]]|0.471|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.47|
|[[:human genes:g:golga6a|GOLGA6A]]|0.47|
|[[:human genes:p:psmb1|PSMB1]]|0.47|
|[[:human genes:r:rpsa|RPSA]]|0.469|
|[[:human genes:v:vps54|VPS54]]|0.467|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.467|
|[[:human genes:p:ppfia4|PPFIA4]]|0.466|
|[[:human genes:m:myo18a|MYO18A]]|0.466|
|[[:human genes:i:iscu|ISCU]]|0.466|
|[[:human genes:p:psmb4|PSMB4]]|0.465|
|[[:human genes:r:ranbp2|RANBP2]]|0.465|
|[[:human genes:r:rpl14|RPL14]]|0.464|
|[[:human genes:s:slc4a1|SLC4A1]]|0.463|
|[[:human genes:z:zfand5|ZFAND5]]|0.462|
|[[:human genes:n:npipb5|NPIPB5]]|0.462|
|[[:human genes:r:rffl|RFFL]]|0.461|
|[[:human genes:w:wdr87|WDR87]]|0.46|
|[[:human genes:s:snrnp70|SNRNP70]]|0.459|
|[[:human genes:c:copz1|COPZ1]]|0.459|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.458|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.456|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.455|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.455|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.455|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.455|
|[[:human genes:n:nup43|NUP43]]|0.454|
|[[:human genes:w:wdr75|WDR75]]|0.453|
|[[:human genes:e:exosc5|EXOSC5]]|0.453|
|[[:human genes:a:acd|ACD]]|0.453|
|[[:human genes:t:twistnb|TWISTNB]]|0.452|
|[[:human genes:m:myt1l|MYT1L]]|0.452|
|[[:human genes:m:myo1h|MYO1H]]|0.45|
|[[:human genes:a:ankle2|ANKLE2]]|0.45|
|[[:human genes:h:hmgcr|HMGCR]]|0.449|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.449|
|[[:human genes:r:rps2|RPS2]]|0.448|
|[[:human genes:p:psmd14|PSMD14]]|0.448|
|[[:human genes:r:rps14|RPS14]]|0.448|
|[[:human genes:p:polr2f|POLR2F]]|0.446|
|[[:human genes:p:plk4|PLK4]]|0.446|
|[[:human genes:p:psmd11|PSMD11]]|0.446|
|[[:human genes:n:nufip2|NUFIP2]]|0.446|
|[[:human genes:p:polr1a|POLR1A]]|0.445|
|[[:human genes:z:znf106|ZNF106]]|0.445|
|[[:human genes:s:sec13|SEC13]]|0.445|
|[[:human genes:a:aaas|AAAS]]|0.445|
|[[:human genes:a:ahctf1|AHCTF1]]|0.444|
|[[:human genes:m:madcam1|MADCAM1]]|0.444|
|[[:human genes:o:ogfr|OGFR]]|0.442|
|[[:human genes:c:chd4|CHD4]]|0.442|
|[[:human genes:u:utp20|UTP20]]|0.442|
|[[:human genes:p:psmc2|PSMC2]]|0.442|
|[[:human genes:c:cln6|CLN6]]|0.442|
|[[:human genes:a:ankle1|ANKLE1]]|0.441|
|[[:human genes:n:nup153|NUP153]]|0.441|
|[[:human genes:c:cactin|CACTIN]]|0.439|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.439|
|[[:human genes:r:rfxank|RFXANK]]|0.438|
|[[:human genes:s:syt9|SYT9]]|0.438|
|[[:human genes:t:ticrr|TICRR]]|0.438|
|[[:human genes:i:ints6|INTS6]]|0.438|
|[[:human genes:s:s1pr4|S1PR4]]|0.438|
|[[:human genes:s:supt6h|SUPT6H]]|0.437|
|[[:human genes:n:nsf|NSF]]|0.437|
|[[:human genes:n:narfl|NARFL]]|0.437|
|[[:human genes:c:cdc45|CDC45]]|0.436|
|[[:human genes:g:gid4|GID4]]|0.435|
|[[:human genes:p:psmc1|PSMC1]]|0.434|
|[[:human genes:p:psmb2|PSMB2]]|0.434|
|[[:human genes:c:copg1|COPG1]]|0.433|
|[[:human genes:s:smg7|SMG7]]|0.433|
|[[:human genes:c:ctr9|CTR9]]|0.432|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.432|
|[[:human genes:e:esf1|ESF1]]|0.43|
|[[:human genes:t:timeless|TIMELESS]]|0.43|
|[[:human genes:o:or10g3|OR10G3]]|0.43|
|[[:human genes:c:cope|COPE]]|0.43|
|[[:human genes:s:snip1|SNIP1]]|0.428|
|[[:human genes:g:gnb3|GNB3]]|0.428|
|[[:human genes:z:znf830|ZNF830]]|0.427|
|[[:human genes:a:arcn1|ARCN1]]|0.427|
|[[:human genes:s:sf3a1|SF3A1]]|0.427|
|[[:human genes:n:nfatc4|NFATC4]]|0.427|
|[[:human genes:c:col2a1|COL2A1]]|0.427|
|[[:human genes:s:smg1|SMG1]]|0.426|
|[[:human genes:a:acbd4|ACBD4]]|0.426|
|[[:human genes:c:cdk12|CDK12]]|0.426|
|[[:human genes:i:ints5|INTS5]]|0.425|
|[[:human genes:p:pola2|POLA2]]|0.424|
|[[:human genes:n:nop16|NOP16]]|0.424|
|[[:human genes:l:lipe|LIPE]]|0.424|
|[[:human genes:s:slc6a17|SLC6A17]]|0.424|
|[[:human genes:s:scaf1|SCAF1]]|0.424|
|[[:human genes:a:aamp|AAMP]]|0.423|
|[[:human genes:p:psmc6|PSMC6]]|0.423|
|[[:human genes:c:casc3|CASC3]]|0.423|
|[[:human genes:a:apc2|APC2]]|0.422|
|[[:human genes:r:rpl6|RPL6]]|0.422|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.422|
|[[:human genes:n:nbpf16|NBPF16]]|0.421|
|[[:human genes:e:elmod3|ELMOD3]]|0.421|
|[[:human genes:m:med14|MED14]]|0.421|
|[[:human genes:g:gga3|GGA3]]|0.42|
|[[:human genes:m:mt1e|MT1E]]|0.42|
|[[:human genes:m:mylk3|MYLK3]]|0.419|
|[[:human genes:t:top1mt|TOP1MT]]|0.419|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.418|
|[[:human genes:p:psmd3|PSMD3]]|0.418|
|[[:human genes:t:taf1|TAF1]]|0.417|
|[[:human genes:k:kif3c|KIF3C]]|0.416|
|[[:human genes:r:rrn3|RRN3]]|0.416|
|[[:human genes:k:kpnb1|KPNB1]]|0.415|
|[[:human genes:t:terf2|TERF2]]|0.415|
|[[:human genes:n:nup205|NUP205]]|0.415|
|[[:human genes:d:dhx38|DHX38]]|0.414|
|[[:human genes:r:rps19|RPS19]]|0.414|
|[[:human genes:a:adra1d|ADRA1D]]|0.414|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.414|
|[[:human genes:r:rpl35|RPL35]]|0.414|
|[[:human genes:p:pwp2|PWP2]]|0.413|
|[[:human genes:c:cbwd5|CBWD5]]|0.413|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.412|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.412|
|[[:human genes:a:atxn1|ATXN1]]|0.412|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.411|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.411|
|[[:human genes:a:aqr|AQR]]|0.411|
|[[:human genes:p:pole|POLE]]|0.411|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.411|
|[[:human genes:c:cbwd3|CBWD3]]|0.411|
|[[:human genes:t:terf1|TERF1]]|0.411|
|[[:human genes:a:aprt|APRT]]|0.41|
|[[:human genes:r:ran|RAN]]|0.41|
|[[:human genes:c:cdc6|CDC6]]|0.41|
|[[:human genes:r:rnf113a|RNF113A]]|0.41|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.41|
|[[:human genes:t:tspy8|TSPY8]]|0.41|
|[[:human genes:m:mdm2|MDM2]]|0.409|
|[[:human genes:s:sel1l|SEL1L]]|0.409|
|[[:human genes:b:bysl|BYSL]]|0.409|
|[[:human genes:n:nup62|NUP62]]|0.408|
|[[:human genes:n:napa|NAPA]]|0.408|
|[[:human genes:r:rps7|RPS7]]|0.407|
|[[:human genes:u:utp3|UTP3]]|0.407|
|[[:human genes:c:chmp4b|CHMP4B]]|0.407|
|[[:human genes:o:otof|OTOF]]|0.407|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.406|
|[[:human genes:a:acsf2|ACSF2]]|0.405|
|[[:human genes:d:dnm2|DNM2]]|0.405|
|[[:human genes:z:znf219|ZNF219]]|0.405|
|[[:human genes:r:rad51|RAD51]]|0.404|
|[[:human genes:g:gar1|GAR1]]|0.404|
|[[:human genes:p:pcf11|PCF11]]|0.404|
|[[:human genes:t:traip|TRAIP]]|0.403|
|[[:human genes:p:psap|PSAP]]|0.403|
|[[:human genes:e:exosc6|EXOSC6]]|0.402|
|[[:human genes:p:prpf3|PRPF3]]|0.401|
|[[:human genes:x:xylt2|XYLT2]]|0.401|
|[[:human genes:g:gramd1a|GRAMD1A]]|0.4|
|[[:human genes:o:osbp|OSBP]]|0.4|
|[[:human genes:i:ints1|INTS1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 232/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|10/28|
|blood|11/28|
|bone|8/25|
|breast|12/33|
|central nervous system|14/56|
|cervix|1/4|
|colorectal|4/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|5/15|
|kidney|4/21|
|liver|8/20|
|lung|20/75|
|lymphocyte|7/14|
|ovary|5/26|
|pancreas|5/24|
|peripheral nervous system|4/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|12/24|
|soft tissue|2/7|
|thyroid|0/2|
|upper aerodigestive|8/22|
|urinary tract|12/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1590
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AKIRIN2 Expression in NALM6 Cells: 5.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>