======= AKT1 =======
== Gene Information ==
* **Official Symbol**: AKT1
* **Official Name**: AKT serine/threonine kinase 1
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=207|207]]
* **UniProt**: [[https://www.uniprot.org/uniprot/P31749|P31749]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=AKT1&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AKT1|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/164730|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011].
* **UniProt Summary**: AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)- response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development. Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr- 117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation. Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation. Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity. Phosphorylation of BAD stimulates its pro- apoptotic activity. Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53.
|Pkinase|
|Pkinase Tyr|
|Pkinase C|
|PH|
|negative regulation of protein kinase activity by protein phosphorylation|
|glycogen cell differentiation involved in embryonic placenta development|
|response to insulin-like growth factor stimulus|
|negative regulation of long-chain fatty acid import into cell|
|regulation of long-chain fatty acid import across plasma membrane|
|positive regulation of endodeoxyribonuclease activity|
|negative regulation of long-chain fatty acid import across plasma membrane|
|activation-induced cell death of T cells|
|positive regulation of deoxyribonuclease activity|
|maintenance of protein location in mitochondrion|
|negative regulation of fatty acid beta-oxidation|
|positive regulation of I-kappaB phosphorylation|
|response to UV-A|
|regulation of I-kappaB phosphorylation|
|regulation of long-chain fatty acid import into cell|
|peripheral nervous system myelin maintenance|
|cellular response to interleukin-18|
|nitric-oxide synthase regulator activity|
|interleukin-18-mediated signaling pathway|
|regulation of endodeoxyribonuclease activity|
|positive regulation of nuclease activity|
|negative regulation of fatty acid transport|
|response to granulocyte macrophage colony-stimulating factor|
|cellular response to granulocyte macrophage colony-stimulating factor stimulus|
|response to interleukin-18|
|negative regulation of fatty acid oxidation|
|cellular response to oxidised low-density lipoprotein particle stimulus|
|negative regulation of cell size|
|positive regulation of mitochondrial membrane potential|
|regulation of deoxyribonuclease activity|
|spongiotrophoblast layer development|
|anoikis|
|positive regulation of fibroblast migration|
|insulin-like growth factor receptor signaling pathway|
|nitric oxide biosynthetic process|
|myelin maintenance|
|T cell apoptotic process|
|negative regulation of lymphocyte migration|
|negative regulation of anion transmembrane transport|
|positive regulation of membrane potential|
|cellular response to prostaglandin E stimulus|
|GTPase activating protein binding|
|positive regulation of glycogen biosynthetic process|
|mammary gland epithelial cell differentiation|
|nitric oxide metabolic process|
|positive regulation of protein localization to cell surface|
|positive regulation of glycogen metabolic process|
|lymphocyte apoptotic process|
|regulation of fatty acid beta-oxidation|
|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|negative regulation of release of cytochrome c from mitochondria|
|glucan biosynthetic process|
|labyrinthine layer blood vessel development|
|glycogen biosynthetic process|
|reactive nitrogen species metabolic process|
|negative regulation of organic acid transport|
|response to food|
|positive regulation of nitric-oxide synthase activity|
|cell migration involved in sprouting angiogenesis|
|regulation of nuclease activity|
|cellular response to prostaglandin stimulus|
|response to prostaglandin E|
|negative regulation of lipid catabolic process|
|leukocyte apoptotic process|
|reactive oxygen species biosynthetic process|
|negative regulation of fatty acid metabolic process|
|myelination in peripheral nervous system|
|negative regulation of lipid transport|
|cell differentiation involved in embryonic placenta development|
|peripheral nervous system axon ensheathment|
|regulation of anion transmembrane transport|
|positive regulation of monooxygenase activity|
|regulation of fatty acid transport|
|response to lipoprotein particle|
|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|negative regulation of anion transport|
|TOR signaling|
|regulation of glycogen biosynthetic process|
|Schwann cell development|
|regulation of glucan biosynthetic process|
|protein serine/threonine/tyrosine kinase activity|
|14-3-3 protein binding|
|cellular response to lipoprotein particle stimulus|
|phosphatidylinositol-3,4-bisphosphate binding|
|regulation of fibroblast migration|
|placenta blood vessel development|
|regulation of fatty acid oxidation|
|blood vessel endothelial cell migration|
|positive regulation of epidermal growth factor receptor signaling pathway|
|positive regulation of cyclin-dependent protein serine/threonine kinase activity|
|hyaluronan metabolic process|
|response to prostaglandin|
|positive regulation of vasoconstriction|
|activation of protein kinase B activity|
|protein phosphatase 2A binding|
|negative regulation of macroautophagy|
|phosphatidylinositol 3-kinase signaling|
|positive regulation of ERBB signaling pathway|
|T cell homeostasis|
|response to growth hormone|
|positive regulation of sodium ion transport|
|lipopolysaccharide-mediated signaling pathway|
|response to fluid shear stress|
|positive regulation of cyclin-dependent protein kinase activity|
|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|regulation of glycogen metabolic process|
|maternal placenta development|
|negative regulation of signal transduction in absence of ligand|
|Schwann cell differentiation|
|positive regulation of G1/S transition of mitotic cell cycle|
|negative regulation of JNK cascade|
|positive regulation of glucose import|
|regulation of polysaccharide biosynthetic process|
|endocrine pancreas development|
|cellular response to cadmium ion|
|regulation of protein localization to cell surface|
|positive regulation of glucose metabolic process|
|protein kinase B signaling|
|maintenance of protein localization in organelle|
|phosphatidylinositol-3,4,5-trisphosphate binding|
|positive regulation of nitric oxide biosynthetic process|
|cellular response to vascular endothelial growth factor stimulus|
|positive regulation of nitric oxide metabolic process|
|negative regulation of lipid localization|
|negative regulation of Notch signaling pathway|
|regulation of myelination|
|positive regulation of glucose transmembrane transport|
|regulation of polysaccharide metabolic process|
|neurotransmitter biosynthetic process|
|cellular response to epidermal growth factor stimulus|
|polysaccharide biosynthetic process|
|regulation of nitric-oxide synthase activity|
|cellular polysaccharide biosynthetic process|
|negative regulation of stress-activated MAPK cascade|
|negative regulation of oxidative stress-induced cell death|
|negative regulation of stress-activated protein kinase signaling cascade|
|negative regulation of leukocyte migration|
|negative regulation of cellular response to oxidative stress|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|negative regulation of protein kinase B signaling|
|labyrinthine layer development|
|positive regulation of cell cycle G1/S phase transition|
|response to epidermal growth factor|
|negative regulation of response to oxidative stress|
|positive regulation of organ growth|
|regulation of release of cytochrome c from mitochondria|
|glycogen metabolic process|
|cellular response to nerve growth factor stimulus|
|positive regulation of reactive oxygen species biosynthetic process|
|cellular glucan metabolic process|
|glucan metabolic process|
|epidermal growth factor receptor signaling pathway|
|response to nerve growth factor|
|positive regulation of oxidoreductase activity|
|lymphocyte homeostasis|
|negative regulation of mitochondrion organization|
|execution phase of apoptosis|
|protein kinase C binding|
|regulation of lipid catabolic process|
|T cell costimulation|
|regulation of monooxygenase activity|
|lymphocyte costimulation|
|cellular response to fatty acid|
|regulation of glucose import|
|positive regulation of blood vessel endothelial cell migration|
|positive regulation of protein localization to plasma membrane|
|regulation of nitric oxide biosynthetic process|
|regulation of vasoconstriction|
|sprouting angiogenesis|
|mammary gland epithelium development|
|positive regulation of cellular carbohydrate metabolic process|
|regulation of organic acid transport|
|apoptotic mitochondrial changes|
|cellular carbohydrate biosynthetic process|
|positive regulation of fat cell differentiation|
|positive regulation of protein localization to cell periphery|
|regulation of lymphocyte migration|
|excitatory postsynaptic potential|
|energy reserve metabolic process|
|regulation of oxidative stress-induced cell death|
|maternal process involved in female pregnancy|
|response to cadmium ion|
|endothelial cell migration|
|chemical synaptic transmission, postsynaptic|
|leukocyte homeostasis|
|I-kappaB kinase/NF-kappaB signaling|
|regulation of mitochondrial membrane potential|
|establishment of protein localization to mitochondrion|
|ERBB signaling pathway|
|positive regulation of blood circulation|
|phosphatidylinositol-mediated signaling|
|pancreas development|
|negative regulation of protein ubiquitination|
|regulation of glucose transmembrane transport|
|peripheral nervous system development|
|maintenance of protein location in cell|
|inositol lipid-mediated signaling|
|regulation of cellular response to oxidative stress|
|positive regulation of protein localization to nucleus|
|carbohydrate transport|
|protein localization to mitochondrion|
|positive regulation of mitotic cell cycle phase transition|
|cellular polysaccharide metabolic process|
|positive regulation of carbohydrate metabolic process|
|cellular response to mechanical stimulus|
|positive regulation of lipid biosynthetic process|
|kinase activity|
|NIK/NF-kappaB signaling|
|polysaccharide metabolic process|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|peptidyl-threonine phosphorylation|
|negative regulation of lipid metabolic process|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|postsynapse|
|epithelial cell migration|
|regulation of epidermal growth factor receptor signaling pathway|
|negative regulation of autophagy|
|negative regulation of protein modification by small protein conjugation or removal|
|response to fatty acid|
|cellular response to alcohol|
|regulation of response to oxidative stress|
|regulation of reactive oxygen species biosynthetic process|
|positive regulation of smooth muscle cell proliferation|
|regulation of sodium ion transport|
|epithelium migration|
|regulation of fatty acid metabolic process|
|embryonic placenta development|
|insulin receptor signaling pathway|
|regulation of blood vessel endothelial cell migration|
|regulation of ERBB signaling pathway|
|neurotransmitter metabolic process|
|negative regulation of cysteine-type endopeptidase activity|
|negative regulation of small molecule metabolic process|
|peptidyl-threonine modification|
|cellular response to ketone|
|plasma membrane organization|
|positive regulation of cell cycle phase transition|
|tissue migration|
|positive regulation of endothelial cell proliferation|
|regulation of organ growth|
|regulation of carbohydrate biosynthetic process|
|regulation of protein localization to plasma membrane|
|protein import into nucleus|
|negative regulation of ion transmembrane transport|
|regulation of oxidoreductase activity|
|maintenance of location in cell|
|negative regulation of intrinsic apoptotic signaling pathway|
|positive regulation of reactive oxygen species metabolic process|
|regulation of anion transport|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of endothelial cell migration|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of postsynaptic membrane potential|
|negative regulation of extrinsic apoptotic signaling pathway|
|regulation of cyclin-dependent protein kinase activity|
|negative regulation of protein binding|
|regulation of Notch signaling pathway|
|positive regulation of proteasomal protein catabolic process|
|positive regulation of peptidyl-serine phosphorylation|
|myelination|
|maintenance of protein location|
|spinal cord development|
|glial cell development|
|mucopolysaccharide metabolic process|
|ensheathment of neurons|
|regulation of lipid transport|
|axon ensheathment|
|response to heat|
|reactive oxygen species metabolic process|
|regulation of glucose metabolic process|
|glucose metabolic process|
|import into nucleus|
|regulation of protein localization to cell periphery|
|negative regulation of transmembrane transport|
|regulation of protein localization to nucleus|
|spindle|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|endocrine system development|
|negative regulation of leukocyte cell-cell adhesion|
|regulation of fat cell differentiation|
|positive regulation of protein localization to membrane|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|carbohydrate biosynthetic process|
|osteoblast differentiation|
|mammary gland development|
|regulation of endothelial cell proliferation|
|cellular response to reactive oxygen species|
|regulation of smooth muscle cell proliferation|
|negative regulation of protein serine/threonine kinase activity|
|ciliary basal body|
|regulation of peptidyl-serine phosphorylation|
|positive regulation of small molecule metabolic process|
|regulation of lipid localization|
|regulation of blood vessel diameter|
|regulation of cellular carbohydrate metabolic process|
|regulation of tube diameter|
|regulation of tube size|
|positive regulation of cellular protein catabolic process|
|positive regulation of epithelial cell migration|
|positive regulation of lipid metabolic process|
|vesicle|
|protein import|
|response to UV|
|negative regulation of ion transport|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|placenta development|
|microtubule cytoskeleton|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of extrinsic apoptotic signaling pathway|
|glycosaminoglycan metabolic process|
|hexose metabolic process|
|regulation of endothelial cell migration|
|regulation of generation of precursor metabolites and energy|
|regulation of intrinsic apoptotic signaling pathway|
|protein localization to nucleus|
|cellular response to insulin stimulus|
|positive regulation of cell growth|
|maintenance of location|
|aminoglycan metabolic process|
|regulation of cell cycle G1/S phase transition|
|negative regulation of MAPK cascade|
|vascular process in circulatory system|
|negative regulation of binding|
|glial cell differentiation|
|cellular carbohydrate metabolic process|
|positive regulation of developmental growth|
|ameboidal-type cell migration|
|regulation of cellular ketone metabolic process|
|cell-cell junction|
|regulation of macroautophagy|
|peptidyl-serine phosphorylation|
|negative regulation of cell-cell adhesion|
|response to temperature stimulus|
|regulation of mRNA stability|
|regulation of reactive oxygen species metabolic process|
|regulation of signal transduction by p53 class mediator|
|female pregnancy|
|regulation of mitochondrion organization|
|regulation of cell size|
|regulation of proteasomal protein catabolic process|
|cellular response to lipopolysaccharide|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|glucose homeostasis|
|regulation of RNA stability|
|regulation of JNK cascade|
|carbohydrate homeostasis|
|regulation of lipid biosynthetic process|
|cellular response to hypoxia|
|positive regulation of epithelial cell proliferation|
|regulation of protein localization to membrane|
|cellular response to molecule of bacterial origin|
|cellular response to metal ion|
|response to ketone|
|protein autophosphorylation|
|positive regulation of DNA metabolic process|
|response to reactive oxygen species|
|regulation of leukocyte migration|
|cellular response to decreased oxygen levels|
|peptidyl-serine modification|
|homeostasis of number of cells|
|monosaccharide metabolic process|
|regulation of protein ubiquitination|
|striated muscle cell differentiation|
|regulation of mRNA catabolic process|
|calmodulin binding|
|positive regulation of transmembrane transport|
|positive regulation of T cell activation|
|regulation of carbohydrate metabolic process|
|negative regulation of neuron death|
|cellular response to acid chemical|
|multi-multicellular organism process|
|response to mechanical stimulus|
|gliogenesis|
|cellular response to oxygen levels|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|cellular response to biotic stimulus|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|regulation of protein binding|
|regulation of protein kinase B signaling|
|regulation of epithelial cell migration|
|cellular response to inorganic substance|
|negative regulation of apoptotic signaling pathway|
|negative regulation of protein kinase activity|
|response to insulin|
|regulation of protein modification by small protein conjugation or removal|
|response to alcohol|
|regulation of stress-activated MAPK cascade|
|energy derivation by oxidation of organic compounds|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of stress-activated protein kinase signaling cascade|
|protein kinase activity|
|cellular response to oxidative stress|
|cellular response to tumor necrosis factor|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|muscle cell differentiation|
|negative regulation of kinase activity|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|positive regulation of cell-cell adhesion|
|negative regulation of peptidase activity|
|germ cell development|
|negative regulation of cell migration|
|positive regulation of growth|
|positive regulation of DNA-binding transcription factor activity|
|ossification|
|response to tumor necrosis factor|
|nucleocytoplasmic transport|
|cellular response to peptide hormone stimulus|
|nuclear transport|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|positive regulation of ion transport|
|negative regulation of transferase activity|
|aging|
|positive regulation of cell cycle process|
|regulation of blood circulation|
|regulation of leukocyte cell-cell adhesion|
|response to light stimulus|
|negative regulation of cellular component movement|
|negative regulation of catabolic process|
|regulation of neuron death|
|response to lipopolysaccharide|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|angiogenesis|
|regulation of T cell activation|
|negative regulation of locomotion|
|positive regulation of cellular protein localization|
|cellular response to peptide|
|response to molecule of bacterial origin|
|activation of protein kinase activity|
|regulation of mRNA metabolic process|
|regulation of developmental growth|
|regulation of autophagy|
|regulation of epithelial cell proliferation|
|cellular response to external stimulus|
|positive regulation of protein serine/threonine kinase activity|
|response to hypoxia|
|response to acid chemical|
|enzyme binding|
|negative regulation of proteolysis|
|regulation of translation|
|regulation of neurotransmitter levels|
|cellular process involved in reproduction in multicellular organism|
|regulation of DNA metabolic process|
|positive regulation of proteolysis|
|response to decreased oxygen levels|
|positive regulation of lymphocyte activation|
|protein serine/threonine kinase activity|
|positive regulation of cellular catabolic process|
|response to metal ion|
|negative regulation of organelle organization|
|in utero embryonic development|
|regulation of binding|
|positive regulation of cell cycle|
|regulation of cellular component size|
|response to oxygen levels|
|translation|
|regulation of protein catabolic process|
|response to oxidative stress|
|regulation of metal ion transport|
|blood circulation|
|response to peptide hormone|
|regulation of lipid metabolic process|
|circulatory system process|
|regulation of cell-cell adhesion|
|regulation of apoptotic signaling pathway|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|regulation of cellular amide metabolic process|
|negative regulation of protein phosphorylation|
|peptide biosynthetic process|
|blood vessel morphogenesis|
|gland development|
|regulation of mitotic cell cycle phase transition|
|positive regulation of cell activation|
|regulation of endopeptidase activity|
|regulation of cell growth|
|endomembrane system organization|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|generation of precursor metabolites and energy|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of small molecule metabolic process|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|regulation of membrane potential|
|positive regulation of catabolic process|
|establishment of protein localization to organelle|
|embryonic organ development|
|trans-synaptic signaling|
|cofactor metabolic process|
|response to radiation|
|mitochondrion organization|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of peptidase activity|
|regulation of cell cycle phase transition|
|negative regulation of hydrolase activity|
|synaptic signaling|
|response to peptide|
|carbohydrate metabolic process|
|muscle structure development|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|blood vessel development|
|regulation of neuron projection development|
|inflammatory response|
|response to nutrient levels|
|positive regulation of cell migration|
|drug metabolic process|
|cellular response to growth factor stimulus|
|negative regulation of intracellular signal transduction|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|cellular response to lipid|
|positive regulation of cell motility|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|response to growth factor|
|response to extracellular stimulus|
|response to inorganic substance|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|positive regulation of locomotion|
|cell population proliferation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|positive regulation of kinase activity|
|regulation of system process|
|negative regulation of protein modification process|
|protein-containing complex|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|regulation of growth|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|epithelial cell differentiation|
|protein catabolic process|
|protein ubiquitination|
|response to bacterium|
|gamete generation|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of ion transport|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|regulation of proteolysis|
|protein localization to organelle|
|regulation of cellular response to stress|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|cellular amide metabolic process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|membrane organization|
|response to lipid|
|circulatory system development|
|regulation of kinase activity|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|response to hormone|
|carboxylic acid metabolic process|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|oxidation-reduction process|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|embryo development|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|regulation of cellular component movement|
|intracellular protein transport|
|regulation of catabolic process|
|multi-organism reproductive process|
|negative regulation of cell death|
|response to organonitrogen compound|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|identical protein binding|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|cell death|
|response to cytokine|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|epithelium development|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|response to abiotic stimulus|
|cell projection organization|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|mitochondrion|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
\\
=== CRISPR Data ===
^Screen^Score^
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.95|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.91|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.8|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.71|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.77|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.87|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.9|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|1.93|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.95|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.96|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.98|
|[[:results:exp453|B02 10μM R08 exp453]]|2.02|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.1|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.16|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.23|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|2.25|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.86|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|3.13|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|3.74|
^Gene^Correlation^
|[[:human genes:m:mapkap1|MAPKAP1]]|0.544|
|[[:human genes:r:rictor|RICTOR]]|0.531|
|[[:human genes:c:cd19|CD19]]|0.497|
|[[:human genes:r:rhoh|RHOH]]|0.487|
|[[:human genes:p:pik3cd|PIK3CD]]|0.471|
|[[:human genes:a:akt2|AKT2]]|0.468|
|[[:human genes:p:pdpk1|PDPK1]]|0.468|
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 8361
* **Expression level (log2 read counts)**: 6.59
{{:chemogenomics:nalm6 dist.png?nolink |}}