======= AKT3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AKT3
  * **<color #00a2e8>Official Name</color>**: AKT serine/threonine kinase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10000|10000]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y243|Q9Y243]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AKT3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AKT3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611223|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the AKT, also called PKB,  serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  AKT3 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase- dependent apoptosis. {ECO:0000269|PubMed:18524868, ECO:0000269|PubMed:21191416}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase C|
|Pkinase Tyr|
|Pkinase|
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of artery morphogenesis|
|positive regulation of artery morphogenesis|
|positive regulation of cell size|
|positive regulation of vascular endothelial cell proliferation|
|negative regulation of cellular senescence|
|mitochondrial genome maintenance|
|regulation of vascular endothelial cell proliferation|
|positive regulation of cell migration involved in sprouting angiogenesis|
|negative regulation of cell aging|
|homeostasis of number of cells within a tissue|
|brain morphogenesis|
|regulation of cell migration involved in sprouting angiogenesis|
|positive regulation of sprouting angiogenesis|
|positive regulation of TOR signaling|
|regulation of cellular senescence|
|regulation of cell aging|
|positive regulation of blood vessel endothelial cell migration|
|regulation of sprouting angiogenesis|
|regulation of blood vessel endothelial cell migration|
|positive regulation of endothelial cell proliferation|
|positive regulation of endothelial cell migration|
|regulation of TOR signaling|
|regulation of endothelial cell proliferation|
|positive regulation of epithelial cell migration|
|regulation of endothelial cell migration|
|positive regulation of angiogenesis|
|peptidyl-serine phosphorylation|
|regulation of cell size|
|positive regulation of vasculature development|
|positive regulation of epithelial cell proliferation|
|tissue homeostasis|
|peptidyl-serine modification|
|homeostasis of number of cells|
|regulation of epithelial cell migration|
|protein kinase activity|
|regulation of angiogenesis|
|regulation of vasculature development|
|multicellular organismal homeostasis|
|regulation of epithelial cell proliferation|
|anatomical structure homeostasis|
|protein serine/threonine kinase activity|
|regulation of cellular component size|
|mitochondrion organization|
|positive regulation of cell migration|
|regulation of anatomical structure size|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|regulation of cellular response to stress|
|brain development|
|head development|
|regulation of cell migration|
|peptidyl-amino acid modification|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|animal organ morphogenesis|
|protein phosphorylation|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of intracellular signal transduction|
|regulation of anatomical structure morphogenesis|
|phosphorylation|
|positive regulation of developmental process|
|regulation of response to stress|
|ATP binding|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12620
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AKT3 Expression in NALM6 Cells: 1.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>