======= ALAS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALAS1
  * **<color #00a2e8>Official Name</color>**: 5'-aminolevulinate synthase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=211|211]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13196|P13196]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALAS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALAS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/125290|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Preseq ALAS|
|Aminotran 1 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|5-aminolevulinate synthase activity|
|protoporphyrinogen IX biosynthetic process|
|protoporphyrinogen IX metabolic process|
|heme biosynthetic process|
|porphyrin-containing compound biosynthetic process|
|tetrapyrrole biosynthetic process|
|heme metabolic process|
|porphyrin-containing compound metabolic process|
|pigment biosynthetic process|
|pyridoxal phosphate binding|
|tetrapyrrole metabolic process|
|pigment metabolic process|
|cofactor biosynthetic process|
|mitochondrial matrix|
|regulation of lipid metabolic process|
|cofactor metabolic process|
|mitochondrion organization|
|identical protein binding|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.7|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.7|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.73|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.75|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.79|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.79|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.79|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.81|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.84|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.84|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|1.87|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.91|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.93|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.94|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.95|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.98|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.04|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.06|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.06|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.08|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|2.1|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.11|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.14|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.15|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.26|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.29|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.33|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|2.44|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.55|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.59|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.73|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.76|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.8|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.82|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.91|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|2.91|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.95|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|3.12|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|3.13|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|3.21|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|3.41|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|3.42|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|3.86|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|4.23|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|4.29|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|8.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fech|FECH]]|0.743|
|[[:human genes:h:hmbs|HMBS]]|0.612|
|[[:human genes:a:alad|ALAD]]|0.519|
|[[:human genes:r:rbfa|RBFA]]|0.477|
|[[:human genes:n:nars2|NARS2]]|0.47|
|[[:human genes:c:cpox|CPOX]]|0.459|
|[[:human genes:b:bak1|BAK1]]|0.456|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.455|
|[[:human genes:y:yars2|YARS2]]|0.447|
|[[:human genes:m:mrpl21|MRPL21]]|0.444|
|[[:human genes:m:mrps21|MRPS21]]|0.443|
|[[:human genes:b:bcs1l|BCS1L]]|0.442|
|[[:human genes:c:c17orf89|C17orf89]]|0.44|
|[[:human genes:t:tefm|TEFM]]|0.44|
|[[:human genes:g:glrx5|GLRX5]]|0.439|
|[[:human genes:n:ndufa11|NDUFA11]]|0.439|
|[[:human genes:n:ndufb11|NDUFB11]]|0.435|
|[[:human genes:t:tars2|TARS2]]|0.434|
|[[:human genes:m:mrps6|MRPS6]]|0.431|
|[[:human genes:c:coq3|COQ3]]|0.431|
|[[:human genes:s:selrc1|SELRC1]]|0.428|
|[[:human genes:m:march5|MARCH5]]|0.428|
|[[:human genes:g:gfm1|GFM1]]|0.427|
|[[:human genes:n:ndufa2|NDUFA2]]|0.426|
|[[:human genes:m:mrps24|MRPS24]]|0.423|
|[[:human genes:m:mrpl47|MRPL47]]|0.42|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.418|
|[[:human genes:t:tufm|TUFM]]|0.418|
|[[:human genes:t:timm17a|TIMM17A]]|0.417|
|[[:human genes:s:sars2|SARS2]]|0.416|
|[[:human genes:w:wbscr16|WBSCR16]]|0.412|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.409|
|[[:human genes:h:hccs|HCCS]]|0.407|
|[[:human genes:r:rpusd4|RPUSD4]]|0.407|
|[[:human genes:l:lrpprc|LRPPRC]]|0.407|
|[[:human genes:m:mrps16|MRPS16]]|0.401|
|[[:human genes:n:ndufc2|NDUFC2]]|0.401|
|[[:human genes:m:mtg1|MTG1]]|0.4|
|[[:human genes:n:ndufa3|NDUFA3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 977
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALAS1 Expression in NALM6 Cells: 5.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>