======= ALDH1A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALDH1A2
  * **<color #00a2e8>Official Name</color>**: aldehyde dehydrogenase 1 family member A2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8854|8854]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94788|O94788]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALDH1A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALDH1A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603687|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aldedh|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retinoic acid receptor signaling pathway involved in somitogenesis|
|9-cis-retinoic acid metabolic process|
|9-cis-retinoic acid biosynthetic process|
|ureter maturation|
|3-chloroallyl aldehyde dehydrogenase activity|
|retinoic acid biosynthetic process|
|retinal dehydrogenase activity|
|vitamin A metabolic process|
|diterpenoid biosynthetic process|
|retinal binding|
|midgut development|
|aldehyde dehydrogenase (NAD) activity|
|retinal metabolic process|
|terpenoid biosynthetic process|
|ureter development|
|retinoic acid receptor signaling pathway|
|response to vitamin A|
|animal organ maturation|
|isoprenoid biosynthetic process|
|retinoic acid metabolic process|
|proximal/distal pattern formation|
|embryonic forelimb morphogenesis|
|embryonic digestive tract development|
|fat-soluble vitamin metabolic process|
|embryonic camera-type eye development|
|retinol metabolic process|
|forelimb morphogenesis|
|pituitary gland development|
|face development|
|cellular aldehyde metabolic process|
|somitogenesis|
|cellular response to retinoic acid|
|pancreas development|
|diencephalon development|
|primary alcohol metabolic process|
|neural crest cell development|
|somite development|
|stem cell development|
|mesenchymal cell development|
|response to vitamin|
|neural crest cell differentiation|
|protein homotetramerization|
|segmentation|
|retinoid metabolic process|
|response to retinoic acid|
|diterpenoid metabolic process|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|endocrine system development|
|determination of bilateral symmetry|
|vitamin metabolic process|
|specification of symmetry|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|liver development|
|hepaticobiliary system development|
|regulation of endothelial cell proliferation|
|digestive tract development|
|anatomical structure maturation|
|response to estradiol|
|isoprenoid metabolic process|
|digestive system development|
|morphogenesis of embryonic epithelium|
|appendage morphogenesis|
|protein tetramerization|
|limb morphogenesis|
|hindbrain development|
|mesenchymal cell differentiation|
|stem cell differentiation|
|neural tube development|
|cardiac muscle tissue development|
|intracellular receptor signaling pathway|
|lung development|
|respiratory tube development|
|appendage development|
|limb development|
|monocarboxylic acid biosynthetic process|
|respiratory system development|
|hormone metabolic process|
|cellular response to acid chemical|
|response to nutrient|
|anterior/posterior pattern specification|
|mesenchyme development|
|developmental maturation|
|heart morphogenesis|
|kidney development|
|renal system development|
|striated muscle tissue development|
|muscle tissue development|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|camera-type eye development|
|alcohol metabolic process|
|urogenital system development|
|regionalization|
|regulation of epithelial cell proliferation|
|protein homooligomerization|
|response to acid chemical|
|eye development|
|visual system development|
|sensory system development|
|forebrain development|
|gland development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|organic hydroxy compound metabolic process|
|blood vessel development|
|response to nutrient levels|
|drug metabolic process|
|vasculature development|
|cardiovascular system development|
|protein complex oligomerization|
|cellular response to lipid|
|heart development|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|regulation of hormone levels|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|negative regulation of cell population proliferation|
|positive regulation of cell death|
|perinuclear region of cytoplasm|
|brain development|
|head development|
|tube development|
|response to lipid|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|carboxylic acid metabolic process|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|cellular lipid metabolic process|
|animal organ morphogenesis|
|oxidation-reduction process|
|embryo development|
|central nervous system development|
|oxoacid metabolic process|
|neuron differentiation|
|organic acid metabolic process|
|cellular response to oxygen-containing compound|
|response to cytokine|
|epithelium development|
|lipid metabolic process|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|regulation of cell death|
|small molecule metabolic process|
|tissue development|
|protein-containing complex subunit organization|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10907
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALDH1A2 Expression in NALM6 Cells: -0.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>