======= ALDH1B1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALDH1B1
  * **<color #00a2e8>Official Name</color>**: aldehyde dehydrogenase 1 family member B1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=219|219]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30837|P30837]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALDH1B1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALDH1B1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/100670|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. This gene does not contain introns in the coding sequence. The variation of this locus may affect the development of alcohol-related problems. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aldedh|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity|
|ethanol oxidation|
|ethanol catabolic process|
|aldehyde dehydrogenase (NAD) activity|
|primary alcohol catabolic process|
|ethanol metabolic process|
|NAD binding|
|antibiotic catabolic process|
|alcohol catabolic process|
|organic hydroxy compound catabolic process|
|primary alcohol metabolic process|
|antibiotic metabolic process|
|drug catabolic process|
|alcohol metabolic process|
|mitochondrial matrix|
|generation of precursor metabolites and energy|
|small molecule catabolic process|
|organic hydroxy compound metabolic process|
|carbohydrate metabolic process|
|drug metabolic process|
|intracellular membrane-bounded organelle|
|oxidation-reduction process|
|mitochondrion|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3c|TCEB3C]]|0.465|
|[[:human genes:d:ddtl|DDTL]]|0.452|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.45|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.446|
|[[:human genes:v:vasn|VASN]]|0.444|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.442|
|[[:human genes:p:prim1|PRIM1]]|0.442|
|[[:human genes:l:lad1|LAD1]]|0.434|
|[[:human genes:c:chd4|CHD4]]|0.432|
|[[:human genes:p:psmb4|PSMB4]]|0.431|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.428|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.427|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.427|
|[[:human genes:x:xab2|XAB2]]|0.425|
|[[:human genes:h:hinfp|HINFP]]|0.425|
|[[:human genes:m:myo18a|MYO18A]]|0.424|
|[[:human genes:g:golga8o|GOLGA8O]]|0.422|
|[[:human genes:n:nupl1|NUPL1]]|0.419|
|[[:human genes:s:supt5h|SUPT5H]]|0.416|
|[[:human genes:s:scgb1c1|SCGB1C1]]|0.414|
|[[:human genes:c:copa|COPA]]|0.414|
|[[:human genes:n:nup160|NUP160]]|0.413|
|[[:human genes:s:slc4a1|SLC4A1]]|0.412|
|[[:human genes:c:copg1|COPG1]]|0.409|
|[[:human genes:p:pola1|POLA1]]|0.406|
|[[:human genes:p:polr2f|POLR2F]]|0.405|
|[[:human genes:p:pwp2|PWP2]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2457
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALDH1B1 Expression in NALM6 Cells: 3.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>