======= ALDOA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALDOA
  * **<color #00a2e8>Official Name</color>**: aldolase, fructose-bisphosphate A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=226|226]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04075|P04075]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALDOA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALDOA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/103850|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Mutations in this gene have been associated with Glycogen Storage Disease XII, an autosomal recessive disorder associated with hemolytic anemia. Disruption of this gene also plays a role in the progression of multiple types of cancers. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Sep 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glycolytic|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fructose-bisphosphate aldolase activity|
|fructose binding|
|sperm head|
|fructose 1,6-bisphosphate metabolic process|
|fructose metabolic process|
|I band|
|muscle cell cellular homeostasis|
|canonical glycolysis|
|NADH regeneration|
|glucose catabolic process to pyruvate|
|glycolytic process through glucose-6-phosphate|
|M band|
|glycolytic process through fructose-6-phosphate|
|glucose catabolic process|
|ATP biosynthetic process|
|binding of sperm to zona pellucida|
|NADH metabolic process|
|glycolytic process|
|ATP generation from ADP|
|gluconeogenesis|
|purine ribonucleoside triphosphate biosynthetic process|
|purine nucleoside triphosphate biosynthetic process|
|NAD metabolic process|
|hexose biosynthetic process|
|ADP metabolic process|
|ribonucleoside triphosphate biosynthetic process|
|sperm-egg recognition|
|hexose catabolic process|
|monosaccharide biosynthetic process|
|tubulin binding|
|tertiary granule lumen|
|nucleoside diphosphate phosphorylation|
|purine ribonucleoside triphosphate metabolic process|
|purine ribonucleoside diphosphate metabolic process|
|purine nucleoside diphosphate metabolic process|
|monosaccharide catabolic process|
|nucleotide phosphorylation|
|nucleoside triphosphate biosynthetic process|
|ribonucleoside diphosphate metabolic process|
|ribonucleoside triphosphate metabolic process|
|platelet alpha granule lumen|
|purine nucleoside triphosphate metabolic process|
|cell-cell recognition|
|pyruvate metabolic process|
|cytoskeletal protein binding|
|nucleoside diphosphate metabolic process|
|protein homotetramerization|
|nucleoside triphosphate metabolic process|
|striated muscle contraction|
|glucose metabolic process|
|secretory granule lumen|
|carbohydrate catabolic process|
|ficolin-1-rich granule lumen|
|carbohydrate biosynthetic process|
|platelet degranulation|
|single fertilization|
|purine ribonucleotide biosynthetic process|
|protein tetramerization|
|regulation of cell shape|
|purine nucleotide biosynthetic process|
|hexose metabolic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|fertilization|
|purine-containing compound biosynthetic process|
|monosaccharide metabolic process|
|ATP metabolic process|
|actin cytoskeleton|
|cell recognition|
|actin filament organization|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|muscle contraction|
|actin binding|
|muscle system process|
|cadherin binding|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|protein homooligomerization|
|anatomical structure homeostasis|
|purine-containing compound metabolic process|
|generation of precursor metabolites and energy|
|small molecule catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|supramolecular fiber organization|
|carbohydrate metabolic process|
|neutrophil degranulation|
|regulation of cell morphogenesis|
|neutrophil activation involved in immune response|
|actin cytoskeleton organization|
|neutrophil mediated immunity|
|drug metabolic process|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|protein complex oligomerization|
|myeloid cell activation involved in immune response|
|monocarboxylic acid metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|actin filament-based process|
|myeloid leukocyte activation|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|sexual reproduction|
|organophosphate metabolic process|
|cellular homeostasis|
|carboxylic acid metabolic process|
|leukocyte activation|
|oxidation-reduction process|
|multi-organism reproductive process|
|oxoacid metabolic process|
|secretion by cell|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|export from cell|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|cell activation|
|immune effector process|
|nucleobase-containing compound biosynthetic process|
|cytoskeleton organization|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|protein-containing complex assembly|
|extracellular space|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|small molecule metabolic process|
|organic substance catabolic process|
|protein-containing complex subunit organization|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-3.13|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-2.77|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-2.31|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.27|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.05|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.89|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.85|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-1.82|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-1.77|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.7|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.71|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.75|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.83|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.84|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.9|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.95|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.24|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|2.33|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.66|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|2.81|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 682/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|26/28|
|bone|26/26|
|breast|27/33|
|central nervous system|54/56|
|cervix|3/4|
|colorectal|15/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|21/21|
|liver|17/20|
|lung|68/75|
|lymphocyte|14/16|
|ovary|22/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|27/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 52
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALDOA Expression in NALM6 Cells: 8.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>