======= ALG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALG1
  * **<color #00a2e8>Official Name</color>**: ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56052|56052]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BT22|Q9BT22]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605907|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The enzyme encoded by this gene catalyzes the first mannosylation step in the biosynthesis of lipid-linked oligosaccharides. This gene is mutated in congenital disorder of glycosylation type Ik. [provided by RefSeq, Dec 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER. {ECO:0000269|PubMed:10704531, ECO:0000269|PubMed:26931382}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glycos transf 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chitobiosyldiphosphodolichol beta-mannosyltransferase activity|
|dolichol-linked oligosaccharide biosynthetic process|
|oligosaccharide-lipid intermediate biosynthetic process|
|mannosyltransferase activity|
|mannosylation|
|protein N-linked glycosylation|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|carbohydrate derivative biosynthetic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.04|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.95|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-1.94|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.91|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.9|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.79|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.79|
|[[:results:exp218|A-395 10μM R05 exp218]]|-1.74|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.74|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.71|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.87|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.91|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.93|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.02|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.16|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pmm2|PMM2]]|0.751|
|[[:human genes:d:dpagt1|DPAGT1]]|0.749|
|[[:human genes:t:thg1l|THG1L]]|0.749|
|[[:human genes:t:triap1|TRIAP1]]|0.693|
|[[:human genes:a:atxn10|ATXN10]]|0.686|
|[[:human genes:u:uap1|UAP1]]|0.682|
|[[:human genes:r:rptor|RPTOR]]|0.671|
|[[:human genes:r:rnmt|RNMT]]|0.67|
|[[:human genes:g:gmppb|GMPPB]]|0.667|
|[[:human genes:u:uhrf1|UHRF1]]|0.661|
|[[:human genes:g:gfpt1|GFPT1]]|0.656|
|[[:human genes:v:vezt|VEZT]]|0.643|
|[[:human genes:r:rpp21|RPP21]]|0.642|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.636|
|[[:human genes:d:dolk|DOLK]]|0.634|
|[[:human genes:a:adsl|ADSL]]|0.633|
|[[:human genes:r:rtcb|RTCB]]|0.632|
|[[:human genes:s:srp14|SRP14]]|0.631|
|[[:human genes:d:dohh|DOHH]]|0.628|
|[[:human genes:p:pelo|PELO]]|0.62|
|[[:human genes:a:alg13|ALG13]]|0.607|
|[[:human genes:m:med16|MED16]]|0.601|
|[[:human genes:g:gemin8|GEMIN8]]|0.6|
|[[:human genes:t:trmt5|TRMT5]]|0.599|
|[[:human genes:a:alg5|ALG5]]|0.595|
|[[:human genes:g:gnb1l|GNB1L]]|0.587|
|[[:human genes:a:atp5j|ATP5J]]|0.583|
|[[:human genes:t:tamm41|TAMM41]]|0.582|
|[[:human genes:a:alg2|ALG2]]|0.582|
|[[:human genes:r:rpe|RPE]]|0.582|
|[[:human genes:u:utp23|UTP23]]|0.581|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.58|
|[[:human genes:a:alg6|ALG6]]|0.579|
|[[:human genes:n:nae1|NAE1]]|0.576|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.574|
|[[:human genes:r:romo1|ROMO1]]|0.574|
|[[:human genes:e:exoc4|EXOC4]]|0.573|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.572|
|[[:human genes:p:ppcs|PPCS]]|0.572|
|[[:human genes:d:dhps|DHPS]]|0.57|
|[[:human genes:s:srd5a3|SRD5A3]]|0.568|
|[[:human genes:t:trnt1|TRNT1]]|0.568|
|[[:human genes:s:slc25a26|SLC25A26]]|0.567|
|[[:human genes:t:tsen54|TSEN54]]|0.567|
|[[:human genes:d:ddx20|DDX20]]|0.565|
|[[:human genes:h:hspd1|HSPD1]]|0.558|
|[[:human genes:e:eny2|ENY2]]|0.558|
|[[:human genes:p:polr3h|POLR3H]]|0.557|
|[[:human genes:o:oraov1|ORAOV1]]|0.557|
|[[:human genes:d:dhrsx|DHRSX]]|0.557|
|[[:human genes:o:osgep|OSGEP]]|0.556|
|[[:human genes:c:cdipt|CDIPT]]|0.556|
|[[:human genes:t:tmem41b|TMEM41B]]|0.554|
|[[:human genes:t:tbcb|TBCB]]|0.553|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.55|
|[[:human genes:u:uba3|UBA3]]|0.548|
|[[:human genes:d:dad1|DAD1]]|0.546|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.543|
|[[:human genes:d:dr1|DR1]]|0.543|
|[[:human genes:w:wdr59|WDR59]]|0.542|
|[[:human genes:r:rpia|RPIA]]|0.542|
|[[:human genes:t:trmt10a|TRMT10A]]|0.541|
|[[:human genes:r:rfk|RFK]]|0.54|
|[[:human genes:t:tti2|TTI2]]|0.537|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.535|
|[[:human genes:t:tti1|TTI1]]|0.535|
|[[:human genes:b:bap1|BAP1]]|0.535|
|[[:human genes:u:ube2g2|UBE2G2]]|0.534|
|[[:human genes:m:mbtps2|MBTPS2]]|0.534|
|[[:human genes:h:haus8|HAUS8]]|0.533|
|[[:human genes:l:lsm10|LSM10]]|0.533|
|[[:human genes:p:pam16|PAM16]]|0.531|
|[[:human genes:t:ten1|TEN1]]|0.531|
|[[:human genes:w:wdr24|WDR24]]|0.531|
|[[:human genes:a:aars|AARS]]|0.528|
|[[:human genes:r:rabggtb|RABGGTB]]|0.527|
|[[:human genes:n:nars|NARS]]|0.526|
|[[:human genes:c:ccdc101|CCDC101]]|0.526|
|[[:human genes:t:taz|TAZ]]|0.521|
|[[:human genes:t:ttc4|TTC4]]|0.519|
|[[:human genes:s:slc25a19|SLC25A19]]|0.518|
|[[:human genes:e:eno1|ENO1]]|0.517|
|[[:human genes:g:gemin6|GEMIN6]]|0.516|
|[[:human genes:r:rft1|RFT1]]|0.516|
|[[:human genes:f:fh|FH]]|0.516|
|[[:human genes:p:ppp6c|PPP6C]]|0.516|
|[[:human genes:e:eef1e1|EEF1E1]]|0.516|
|[[:human genes:t:telo2|TELO2]]|0.515|
|[[:human genes:k:kdsr|KDSR]]|0.515|
|[[:human genes:c:csnk2b|CSNK2B]]|0.515|
|[[:human genes:m:med4|MED4]]|0.514|
|[[:human genes:c:cbfb|CBFB]]|0.51|
|[[:human genes:d:ddx55|DDX55]]|0.508|
|[[:human genes:e:elac2|ELAC2]]|0.508|
|[[:human genes:t:txnrd1|TXNRD1]]|0.508|
|[[:human genes:d:ddx1|DDX1]]|0.506|
|[[:human genes:z:zrsr2|ZRSR2]]|0.503|
|[[:human genes:p:plaa|PLAA]]|0.503|
|[[:human genes:m:mtor|MTOR]]|0.503|
|[[:human genes:p:ppa2|PPA2]]|0.503|
|[[:human genes:d:ddost|DDOST]]|0.503|
|[[:human genes:m:meaf6|MEAF6]]|0.503|
|[[:human genes:a:atic|ATIC]]|0.503|
|[[:human genes:y:yars|YARS]]|0.502|
|[[:human genes:d:dpf2|DPF2]]|0.502|
|[[:human genes:t:tprkb|TPRKB]]|0.502|
|[[:human genes:a:atp5o|ATP5O]]|0.501|
|[[:human genes:u:uxt|UXT]]|0.499|
|[[:human genes:p:ppp4c|PPP4C]]|0.498|
|[[:human genes:r:rad1|RAD1]]|0.497|
|[[:human genes:s:sec62|SEC62]]|0.497|
|[[:human genes:e:eif4e|EIF4E]]|0.497|
|[[:human genes:h:hccs|HCCS]]|0.496|
|[[:human genes:v:vmp1|VMP1]]|0.493|
|[[:human genes:u:urm1|URM1]]|0.493|
|[[:human genes:c:crls1|CRLS1]]|0.491|
|[[:human genes:t:thoc6|THOC6]]|0.491|
|[[:human genes:a:atp5b|ATP5B]]|0.489|
|[[:human genes:t:txnl4b|TXNL4B]]|0.489|
|[[:human genes:g:gemin7|GEMIN7]]|0.489|
|[[:human genes:v:vrk1|VRK1]]|0.488|
|[[:human genes:t:tsen34|TSEN34]]|0.488|
|[[:human genes:t:tbca|TBCA]]|0.487|
|[[:human genes:d:dnlz|DNLZ]]|0.486|
|[[:human genes:r:rpn1|RPN1]]|0.485|
|[[:human genes:t:timm13|TIMM13]]|0.485|
|[[:human genes:e:exoc3|EXOC3]]|0.484|
|[[:human genes:s:ssb|SSB]]|0.483|
|[[:human genes:e:elp3|ELP3]]|0.483|
|[[:human genes:a:alg14|ALG14]]|0.483|
|[[:human genes:f:fnta|FNTA]]|0.482|
|[[:human genes:p:pdap1|PDAP1]]|0.482|
|[[:human genes:e:eprs|EPRS]]|0.482|
|[[:human genes:n:nsmce1|NSMCE1]]|0.482|
|[[:human genes:e:elp2|ELP2]]|0.482|
|[[:human genes:c:casp9|CASP9]]|0.481|
|[[:human genes:a:atp2a2|ATP2A2]]|0.479|
|[[:human genes:h:hars|HARS]]|0.479|
|[[:human genes:c:cct7|CCT7]]|0.478|
|[[:human genes:d:dnajc3|DNAJC3]]|0.476|
|[[:human genes:t:timm22|TIMM22]]|0.476|
|[[:human genes:p:pggt1b|PGGT1B]]|0.472|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.472|
|[[:human genes:b:bub3|BUB3]]|0.471|
|[[:human genes:d:ddx39a|DDX39A]]|0.47|
|[[:human genes:t:tpk1|TPK1]]|0.47|
|[[:human genes:t:tbp|TBP]]|0.469|
|[[:human genes:c:cep57|CEP57]]|0.469|
|[[:human genes:m:mrps33|MRPS33]]|0.468|
|[[:human genes:t:tkt|TKT]]|0.467|
|[[:human genes:t:trmt61a|TRMT61A]]|0.467|
|[[:human genes:c:chchd4|CHCHD4]]|0.466|
|[[:human genes:t:tgs1|TGS1]]|0.465|
|[[:human genes:r:rbm14|RBM14]]|0.465|
|[[:human genes:w:wdr1|WDR1]]|0.464|
|[[:human genes:s:srp68|SRP68]]|0.46|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.46|
|[[:human genes:u:ube2j1|UBE2J1]]|0.46|
|[[:human genes:c:c15orf41|C15orf41]]|0.458|
|[[:human genes:t:timm10|TIMM10]]|0.458|
|[[:human genes:p:pgm3|PGM3]]|0.457|
|[[:human genes:u:uso1|USO1]]|0.457|
|[[:human genes:l:lsm11|LSM11]]|0.456|
|[[:human genes:c:cmtr1|CMTR1]]|0.456|
|[[:human genes:n:nbn|NBN]]|0.455|
|[[:human genes:a:apaf1|APAF1]]|0.454|
|[[:human genes:t:tmed10|TMED10]]|0.453|
|[[:human genes:c:ctc1|CTC1]]|0.452|
|[[:human genes:g:gtf3c5|GTF3C5]]|0.452|
|[[:human genes:s:snapc5|SNAPC5]]|0.452|
|[[:human genes:g:gtf3a|GTF3A]]|0.452|
|[[:human genes:m:mllt1|MLLT1]]|0.451|
|[[:human genes:s:sec63|SEC63]]|0.45|
|[[:human genes:t:taf1a|TAF1A]]|0.45|
|[[:human genes:p:pyroxd1|PYROXD1]]|0.449|
|[[:human genes:f:faf2|FAF2]]|0.448|
|[[:human genes:m:mapk14|MAPK14]]|0.448|
|[[:human genes:s:slc35b1|SLC35B1]]|0.448|
|[[:human genes:b:bak1|BAK1]]|0.447|
|[[:human genes:c:crcp|CRCP]]|0.447|
|[[:human genes:g:gemin5|GEMIN5]]|0.447|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.446|
|[[:human genes:s:srp72|SRP72]]|0.445|
|[[:human genes:f:fen1|FEN1]]|0.445|
|[[:human genes:a:atp5d|ATP5D]]|0.444|
|[[:human genes:y:yars2|YARS2]]|0.444|
|[[:human genes:k:kctd5|KCTD5]]|0.443|
|[[:human genes:t:tmem242|TMEM242]]|0.443|
|[[:human genes:u:ube2k|UBE2K]]|0.441|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.44|
|[[:human genes:u:uba5|UBA5]]|0.44|
|[[:human genes:a:alg8|ALG8]]|0.438|
|[[:human genes:k:kdm8|KDM8]]|0.438|
|[[:human genes:o:oip5|OIP5]]|0.436|
|[[:human genes:a:atp5a1|ATP5A1]]|0.435|
|[[:human genes:d:dars2|DARS2]]|0.435|
|[[:human genes:m:msto1|MSTO1]]|0.434|
|[[:human genes:m:mis18a|MIS18A]]|0.434|
|[[:human genes:p:polr3c|POLR3C]]|0.432|
|[[:human genes:w:wdr82|WDR82]]|0.432|
|[[:human genes:s:sdha|SDHA]]|0.431|
|[[:human genes:m:med23|MED23]]|0.431|
|[[:human genes:z:zbtb11|ZBTB11]]|0.429|
|[[:human genes:m:mrpl23|MRPL23]]|0.428|
|[[:human genes:s:spr|SPR]]|0.428|
|[[:human genes:d:dusp12|DUSP12]]|0.428|
|[[:human genes:v:vhl|VHL]]|0.428|
|[[:human genes:p:polr3b|POLR3B]]|0.427|
|[[:human genes:l:lsmd1|LSMD1]]|0.427|
|[[:human genes:d:dctn6|DCTN6]]|0.427|
|[[:human genes:p:pik3r4|PIK3R4]]|0.426|
|[[:human genes:n:ndufb1|NDUFB1]]|0.425|
|[[:human genes:p:ppcdc|PPCDC]]|0.425|
|[[:human genes:z:zzz3|ZZZ3]]|0.423|
|[[:human genes:a:atp5h|ATP5H]]|0.423|
|[[:human genes:z:znf259|ZNF259]]|0.422|
|[[:human genes:p:pdss1|PDSS1]]|0.422|
|[[:human genes:s:snf8|SNF8]]|0.422|
|[[:human genes:m:mrps34|MRPS34]]|0.421|
|[[:human genes:s:seh1l|SEH1L]]|0.42|
|[[:human genes:p:pax5|PAX5]]|0.419|
|[[:human genes:x:xrcc2|XRCC2]]|0.419|
|[[:human genes:p:phb|PHB]]|0.418|
|[[:human genes:n:naa20|NAA20]]|0.418|
|[[:human genes:s:srprb|SRPRB]]|0.418|
|[[:human genes:s:spcs2|SPCS2]]|0.417|
|[[:human genes:m:mrps2|MRPS2]]|0.417|
|[[:human genes:d:dpm3|DPM3]]|0.417|
|[[:human genes:r:rad50|RAD50]]|0.417|
|[[:human genes:w:wdr92|WDR92]]|0.416|
|[[:human genes:s:sec61g|SEC61G]]|0.416|
|[[:human genes:e:eif3f|EIF3F]]|0.415|
|[[:human genes:r:rbmx2|RBMX2]]|0.415|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.414|
|[[:human genes:u:ube2m|UBE2M]]|0.413|
|[[:human genes:p:pisd|PISD]]|0.413|
|[[:human genes:f:fntb|FNTB]]|0.413|
|[[:human genes:v:vma21|VMA21]]|0.412|
|[[:human genes:d:dnajb11|DNAJB11]]|0.412|
|[[:human genes:c:c14orf166|C14orf166]]|0.412|
|[[:human genes:t:thoc3|THOC3]]|0.412|
|[[:human genes:g:gfer|GFER]]|0.412|
|[[:human genes:n:nsd1|NSD1]]|0.411|
|[[:human genes:u:ufsp2|UFSP2]]|0.41|
|[[:human genes:c:ccdc115|CCDC115]]|0.408|
|[[:human genes:d:dhdds|DHDDS]]|0.408|
|[[:human genes:m:mrps14|MRPS14]]|0.406|
|[[:human genes:d:dicer1|DICER1]]|0.405|
|[[:human genes:s:srpk1|SRPK1]]|0.405|
|[[:human genes:s:sars2|SARS2]]|0.405|
|[[:human genes:p:pkm|PKM]]|0.404|
|[[:human genes:t:trmt6|TRMT6]]|0.404|
|[[:human genes:o:opa1|OPA1]]|0.404|
|[[:human genes:s:sgol1|SGOL1]]|0.404|
|[[:human genes:o:otud5|OTUD5]]|0.404|
|[[:human genes:c:c14orf80|C14orf80]]|0.403|
|[[:human genes:m:mars|MARS]]|0.403|
|[[:human genes:c:c17orf89|C17orf89]]|0.402|
|[[:human genes:s:spcs3|SPCS3]]|0.401|
|[[:human genes:m:mrps18a|MRPS18A]]|0.401|
|[[:human genes:m:mrps11|MRPS11]]|0.401|
|[[:human genes:c:cbx3|CBX3]]|0.401|
|[[:human genes:t:tufm|TUFM]]|0.4|
|[[:human genes:t:top3a|TOP3A]]|0.4|
|[[:human genes:c:c1orf27|C1orf27]]|0.4|
|[[:human genes:n:nup50|NUP50]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 469/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|15/28|
|blood|13/28|
|bone|12/26|
|breast|15/33|
|central nervous system|50/56|
|cervix|4/4|
|colorectal|4/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|9/16|
|kidney|15/21|
|liver|18/20|
|lung|43/75|
|lymphocyte|8/16|
|ovary|18/26|
|pancreas|14/24|
|peripheral nervous system|8/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|20/24|
|soft tissue|5/9|
|thyroid|2/2|
|upper aerodigestive|15/22|
|urinary tract|21/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1612
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALG1 Expression in NALM6 Cells: 5.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>