======= ALG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALG2
  * **<color #00a2e8>Official Name</color>**: ALG2 alpha-1,3/1,6-mannosyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=85365|85365]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H553|Q9H553]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607905|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate. {ECO:0000269|PubMed:12684507}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glycos transf 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity|
|GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity|
|protein glycosylation in endoplasmic reticulum|
|alpha-1,3-mannosyltransferase activity|
|dolichol-linked oligosaccharide biosynthetic process|
|oligosaccharide-lipid intermediate biosynthetic process|
|mannosylation|
|calcium-dependent protein binding|
|protein N-linked glycosylation|
|protein N-terminus binding|
|response to calcium ion|
|actin cytoskeleton|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|response to metal ion|
|glycoprotein metabolic process|
|protein heterodimerization activity|
|response to inorganic substance|
|carbohydrate derivative biosynthetic process|
|perinuclear region of cytoplasm|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.7|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.8|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.81|
|[[:results:exp539|42°C R08 exp539]]|1.87|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.88|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.9|
|[[:results:exp518|RK-33 8μM R08 exp518]]|1.92|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.08|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.39|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pmm2|PMM2]]|0.686|
|[[:human genes:d:dpagt1|DPAGT1]]|0.639|
|[[:human genes:g:gmppb|GMPPB]]|0.636|
|[[:human genes:t:thg1l|THG1L]]|0.618|
|[[:human genes:u:uap1|UAP1]]|0.597|
|[[:human genes:r:rnmt|RNMT]]|0.591|
|[[:human genes:a:alg1|ALG1]]|0.582|
|[[:human genes:g:gfpt1|GFPT1]]|0.573|
|[[:human genes:r:rtcb|RTCB]]|0.564|
|[[:human genes:r:rptor|RPTOR]]|0.563|
|[[:human genes:g:gnb1l|GNB1L]]|0.56|
|[[:human genes:t:tti1|TTI1]]|0.558|
|[[:human genes:o:oraov1|ORAOV1]]|0.554|
|[[:human genes:r:rpn1|RPN1]]|0.551|
|[[:human genes:d:dohh|DOHH]]|0.549|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.546|
|[[:human genes:h:hars|HARS]]|0.546|
|[[:human genes:p:pelo|PELO]]|0.545|
|[[:human genes:h:hspd1|HSPD1]]|0.545|
|[[:human genes:m:med16|MED16]]|0.543|
|[[:human genes:e:exoc4|EXOC4]]|0.542|
|[[:human genes:a:atxn10|ATXN10]]|0.539|
|[[:human genes:a:atp5j|ATP5J]]|0.535|
|[[:human genes:p:pam16|PAM16]]|0.535|
|[[:human genes:a:alg13|ALG13]]|0.535|
|[[:human genes:t:tamm41|TAMM41]]|0.534|
|[[:human genes:c:ccdc101|CCDC101]]|0.532|
|[[:human genes:o:osgep|OSGEP]]|0.529|
|[[:human genes:a:aars|AARS]]|0.523|
|[[:human genes:t:ttc4|TTC4]]|0.523|
|[[:human genes:y:yars|YARS]]|0.522|
|[[:human genes:a:alg5|ALG5]]|0.521|
|[[:human genes:t:triap1|TRIAP1]]|0.514|
|[[:human genes:r:rpp21|RPP21]]|0.514|
|[[:human genes:d:ddost|DDOST]]|0.51|
|[[:human genes:v:vezt|VEZT]]|0.507|
|[[:human genes:e:eny2|ENY2]]|0.503|
|[[:human genes:v:vmp1|VMP1]]|0.503|
|[[:human genes:g:gpn2|GPN2]]|0.503|
|[[:human genes:t:tti2|TTI2]]|0.502|
|[[:human genes:t:trmt5|TRMT5]]|0.499|
|[[:human genes:e:eprs|EPRS]]|0.498|
|[[:human genes:n:nae1|NAE1]]|0.498|
|[[:human genes:c:csnk2b|CSNK2B]]|0.497|
|[[:human genes:t:tsen34|TSEN34]]|0.495|
|[[:human genes:u:utp23|UTP23]]|0.493|
|[[:human genes:m:mtor|MTOR]]|0.489|
|[[:human genes:t:taz|TAZ]]|0.486|
|[[:human genes:b:bap1|BAP1]]|0.481|
|[[:human genes:t:tsen54|TSEN54]]|0.48|
|[[:human genes:p:polr3b|POLR3B]]|0.478|
|[[:human genes:d:dad1|DAD1]]|0.477|
|[[:human genes:s:srp72|SRP72]]|0.476|
|[[:human genes:t:telo2|TELO2]]|0.475|
|[[:human genes:c:cars|CARS]]|0.474|
|[[:human genes:e:elac2|ELAC2]]|0.473|
|[[:human genes:e:eif4e|EIF4E]]|0.473|
|[[:human genes:p:polr3h|POLR3H]]|0.472|
|[[:human genes:h:haus8|HAUS8]]|0.468|
|[[:human genes:s:spcs2|SPCS2]]|0.467|
|[[:human genes:w:wdr24|WDR24]]|0.466|
|[[:human genes:t:tgs1|TGS1]]|0.466|
|[[:human genes:c:casp9|CASP9]]|0.465|
|[[:human genes:d:dhps|DHPS]]|0.464|
|[[:human genes:n:nars|NARS]]|0.463|
|[[:human genes:c:cct7|CCT7]]|0.461|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.461|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.459|
|[[:human genes:d:ddx20|DDX20]]|0.459|
|[[:human genes:h:hccs|HCCS]]|0.459|
|[[:human genes:c:cbfb|CBFB]]|0.456|
|[[:human genes:s:srp14|SRP14]]|0.455|
|[[:human genes:v:vrk1|VRK1]]|0.455|
|[[:human genes:r:rpe|RPE]]|0.454|
|[[:human genes:l:lsm11|LSM11]]|0.454|
|[[:human genes:t:trnt1|TRNT1]]|0.453|
|[[:human genes:u:uxt|UXT]]|0.453|
|[[:human genes:g:gemin5|GEMIN5]]|0.452|
|[[:human genes:w:wdr59|WDR59]]|0.449|
|[[:human genes:a:apaf1|APAF1]]|0.448|
|[[:human genes:d:ddx1|DDX1]]|0.447|
|[[:human genes:a:adsl|ADSL]]|0.446|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.445|
|[[:human genes:t:tprkb|TPRKB]]|0.443|
|[[:human genes:t:tbca|TBCA]]|0.44|
|[[:human genes:t:tmem41b|TMEM41B]]|0.439|
|[[:human genes:p:plaa|PLAA]]|0.438|
|[[:human genes:n:nsmce1|NSMCE1]]|0.438|
|[[:human genes:p:pax5|PAX5]]|0.438|
|[[:human genes:a:atp2a2|ATP2A2]]|0.438|
|[[:human genes:r:romo1|ROMO1]]|0.437|
|[[:human genes:u:uhrf1|UHRF1]]|0.436|
|[[:human genes:a:alg14|ALG14]]|0.436|
|[[:human genes:m:meaf6|MEAF6]]|0.436|
|[[:human genes:m:med4|MED4]]|0.434|
|[[:human genes:m:mbtps2|MBTPS2]]|0.432|
|[[:human genes:n:nsd1|NSD1]]|0.432|
|[[:human genes:r:rfk|RFK]]|0.426|
|[[:human genes:s:slc35b1|SLC35B1]]|0.425|
|[[:human genes:d:dhdds|DHDDS]]|0.424|
|[[:human genes:m:mis18a|MIS18A]]|0.424|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.424|
|[[:human genes:g:gemin6|GEMIN6]]|0.422|
|[[:human genes:s:slc25a19|SLC25A19]]|0.42|
|[[:human genes:s:sec16a|SEC16A]]|0.42|
|[[:human genes:a:atp5o|ATP5O]]|0.418|
|[[:human genes:o:opa1|OPA1]]|0.417|
|[[:human genes:q:qars|QARS]]|0.417|
|[[:human genes:e:eef1e1|EEF1E1]]|0.417|
|[[:human genes:d:dr1|DR1]]|0.416|
|[[:human genes:u:uba3|UBA3]]|0.416|
|[[:human genes:u:ube2g2|UBE2G2]]|0.416|
|[[:human genes:s:srp68|SRP68]]|0.416|
|[[:human genes:t:tle4|TLE4]]|0.415|
|[[:human genes:a:atp5b|ATP5B]]|0.415|
|[[:human genes:f:fnta|FNTA]]|0.415|
|[[:human genes:p:ppcs|PPCS]]|0.414|
|[[:human genes:g:gtf3a|GTF3A]]|0.413|
|[[:human genes:t:thoc3|THOC3]]|0.413|
|[[:human genes:u:ube2j1|UBE2J1]]|0.411|
|[[:human genes:c:c14orf166|C14orf166]]|0.411|
|[[:human genes:t:thoc6|THOC6]]|0.411|
|[[:human genes:t:txnrd1|TXNRD1]]|0.411|
|[[:human genes:z:zrsr2|ZRSR2]]|0.41|
|[[:human genes:t:tbcb|TBCB]]|0.409|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.409|
|[[:human genes:c:cdipt|CDIPT]]|0.409|
|[[:human genes:d:dicer1|DICER1]]|0.409|
|[[:human genes:m:mllt1|MLLT1]]|0.409|
|[[:human genes:p:pdap1|PDAP1]]|0.408|
|[[:human genes:d:dnajc3|DNAJC3]]|0.408|
|[[:human genes:s:slc25a26|SLC25A26]]|0.408|
|[[:human genes:s:snapc5|SNAPC5]]|0.408|
|[[:human genes:o:orc5|ORC5]]|0.407|
|[[:human genes:a:actr10|ACTR10]]|0.406|
|[[:human genes:p:ppa2|PPA2]]|0.406|
|[[:human genes:s:sec62|SEC62]]|0.405|
|[[:human genes:s:sdha|SDHA]]|0.403|
|[[:human genes:m:mapk14|MAPK14]]|0.402|
|[[:human genes:s:spcs3|SPCS3]]|0.401|
|[[:human genes:b:bak1|BAK1]]|0.401|
|[[:human genes:n:nxt1|NXT1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 714/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|28/28|
|bone|26/26|
|breast|26/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|70/75|
|lymphocyte|15/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|14/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 911
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALG2 Expression in NALM6 Cells: 5.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>