======= ALG5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALG5
  * **<color #00a2e8>Official Name</color>**: ALG5 dolichyl-phosphate beta-glucosyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29880|29880]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y673|Q9Y673]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALG5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALG5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604565|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glycos transf 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dolichyl-phosphate beta-glucosyltransferase activity|
|oligosaccharyl transferase activity|
|protein N-linked glycosylation via asparagine|
|peptidyl-asparagine modification|
|protein N-linked glycosylation|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|pattern specification process|
|carbohydrate derivative biosynthetic process|
|peptidyl-amino acid modification|
|endoplasmic reticulum membrane|
|carbohydrate derivative metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.55|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|-2.43|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-2.37|
|[[:results:exp115|A-366 10μM R03 exp115]]|-2.2|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.13|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-2.07|
|[[:results:exp495|IWR1 50μM R08 exp495]]|-2.01|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.98|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.98|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.96|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.96|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.96|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.93|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.92|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-1.89|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.88|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.87|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.87|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.87|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.85|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.85|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.85|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-1.84|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.83|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-1.81|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.8|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.78|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.76|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.76|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.75|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.72|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-1.71|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.7|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.7|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.71|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.72|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.77|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.79|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.79|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.87|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.91|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.99|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.99|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2|
|[[:results:exp17|DABN 20μM R00 exp17]]|2|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|2.02|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.1|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.15|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.18|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.33|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|2.45|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.47|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.47|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.68|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.95|
|[[:results:exp539|42°C R08 exp539]]|3.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pmm2|PMM2]]|0.642|
|[[:human genes:d:dpagt1|DPAGT1]]|0.61|
|[[:human genes:a:alg6|ALG6]]|0.608|
|[[:human genes:g:gfpt1|GFPT1]]|0.604|
|[[:human genes:a:alg1|ALG1]]|0.595|
|[[:human genes:d:dnajc3|DNAJC3]]|0.593|
|[[:human genes:t:triap1|TRIAP1]]|0.59|
|[[:human genes:r:rnmt|RNMT]]|0.589|
|[[:human genes:u:uap1|UAP1]]|0.579|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.577|
|[[:human genes:e:eny2|ENY2]]|0.57|
|[[:human genes:h:hars|HARS]]|0.563|
|[[:human genes:g:gmppb|GMPPB]]|0.561|
|[[:human genes:u:ube2j1|UBE2J1]]|0.556|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.551|
|[[:human genes:m:manf|MANF]]|0.55|
|[[:human genes:t:tmed10|TMED10]]|0.55|
|[[:human genes:c:cbfb|CBFB]]|0.547|
|[[:human genes:u:ube2g2|UBE2G2]]|0.544|
|[[:human genes:p:pggt1b|PGGT1B]]|0.541|
|[[:human genes:d:dnajb11|DNAJB11]]|0.538|
|[[:human genes:m:mapk14|MAPK14]]|0.536|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.533|
|[[:human genes:r:rptor|RPTOR]]|0.532|
|[[:human genes:a:aars|AARS]]|0.529|
|[[:human genes:d:derl1|DERL1]]|0.529|
|[[:human genes:r:rpe|RPE]]|0.527|
|[[:human genes:s:sec62|SEC62]]|0.526|
|[[:human genes:d:dohh|DOHH]]|0.522|
|[[:human genes:a:atp5j|ATP5J]]|0.522|
|[[:human genes:a:alg2|ALG2]]|0.521|
|[[:human genes:h:hspd1|HSPD1]]|0.519|
|[[:human genes:p:ppa2|PPA2]]|0.519|
|[[:human genes:m:mbtps2|MBTPS2]]|0.517|
|[[:human genes:c:ccdc101|CCDC101]]|0.515|
|[[:human genes:u:uba5|UBA5]]|0.514|
|[[:human genes:a:atxn10|ATXN10]]|0.514|
|[[:human genes:s:sec63|SEC63]]|0.51|
|[[:human genes:r:rtcb|RTCB]]|0.509|
|[[:human genes:c:crls1|CRLS1]]|0.508|
|[[:human genes:t:thg1l|THG1L]]|0.507|
|[[:human genes:t:trmt5|TRMT5]]|0.505|
|[[:human genes:t:tmem41b|TMEM41B]]|0.505|
|[[:human genes:v:vmp1|VMP1]]|0.503|
|[[:human genes:t:timm13|TIMM13]]|0.5|
|[[:human genes:d:dad1|DAD1]]|0.5|
|[[:human genes:u:uso1|USO1]]|0.5|
|[[:human genes:d:derl2|DERL2]]|0.499|
|[[:human genes:s:srp14|SRP14]]|0.497|
|[[:human genes:b:bap1|BAP1]]|0.493|
|[[:human genes:r:romo1|ROMO1]]|0.491|
|[[:human genes:a:alg9|ALG9]]|0.491|
|[[:human genes:s:sec61b|SEC61B]]|0.489|
|[[:human genes:d:dolk|DOLK]]|0.487|
|[[:human genes:c:csnk2b|CSNK2B]]|0.487|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.486|
|[[:human genes:d:dpf2|DPF2]]|0.486|
|[[:human genes:a:atp5a1|ATP5A1]]|0.483|
|[[:human genes:t:trmt10a|TRMT10A]]|0.481|
|[[:human genes:t:taz|TAZ]]|0.48|
|[[:human genes:u:uhrf1|UHRF1]]|0.478|
|[[:human genes:p:pam16|PAM16]]|0.478|
|[[:human genes:u:utp23|UTP23]]|0.476|
|[[:human genes:s:srp68|SRP68]]|0.476|
|[[:human genes:e:eif4e|EIF4E]]|0.474|
|[[:human genes:u:ube2k|UBE2K]]|0.473|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.472|
|[[:human genes:m:meaf6|MEAF6]]|0.471|
|[[:human genes:n:nxt1|NXT1]]|0.47|
|[[:human genes:s:slc25a26|SLC25A26]]|0.47|
|[[:human genes:o:opa1|OPA1]]|0.47|
|[[:human genes:s:srd5a3|SRD5A3]]|0.469|
|[[:human genes:o:oraov1|ORAOV1]]|0.469|
|[[:human genes:a:atp5o|ATP5O]]|0.469|
|[[:human genes:d:dhps|DHPS]]|0.469|
|[[:human genes:u:ufm1|UFM1]]|0.465|
|[[:human genes:s:sdha|SDHA]]|0.464|
|[[:human genes:t:tamm41|TAMM41]]|0.464|
|[[:human genes:d:dpm3|DPM3]]|0.463|
|[[:human genes:s:sec16a|SEC16A]]|0.462|
|[[:human genes:e:exoc4|EXOC4]]|0.461|
|[[:human genes:v:vezt|VEZT]]|0.461|
|[[:human genes:a:alg13|ALG13]]|0.46|
|[[:human genes:t:thoc6|THOC6]]|0.459|
|[[:human genes:g:gnb1l|GNB1L]]|0.459|
|[[:human genes:a:alg14|ALG14]]|0.458|
|[[:human genes:v:vrk1|VRK1]]|0.456|
|[[:human genes:w:wdr24|WDR24]]|0.455|
|[[:human genes:a:atp5b|ATP5B]]|0.455|
|[[:human genes:t:tsen54|TSEN54]]|0.454|
|[[:human genes:m:mrps33|MRPS33]]|0.451|
|[[:human genes:h:haus8|HAUS8]]|0.451|
|[[:human genes:t:tti2|TTI2]]|0.45|
|[[:human genes:m:med25|MED25]]|0.45|
|[[:human genes:x:xpo6|XPO6]]|0.448|
|[[:human genes:p:pelo|PELO]]|0.448|
|[[:human genes:o:otud5|OTUD5]]|0.448|
|[[:human genes:m:med16|MED16]]|0.446|
|[[:human genes:n:nsmce1|NSMCE1]]|0.446|
|[[:human genes:p:polr3h|POLR3H]]|0.446|
|[[:human genes:c:cycs|CYCS]]|0.443|
|[[:human genes:s:stt3a|STT3A]]|0.442|
|[[:human genes:m:mars|MARS]]|0.441|
|[[:human genes:r:rad1|RAD1]]|0.441|
|[[:human genes:n:nae1|NAE1]]|0.44|
|[[:human genes:f:flvcr1|FLVCR1]]|0.439|
|[[:human genes:p:pisd|PISD]]|0.439|
|[[:human genes:n:nupl2|NUPL2]]|0.438|
|[[:human genes:l:lsm10|LSM10]]|0.437|
|[[:human genes:c:c14orf2|C14orf2]]|0.437|
|[[:human genes:d:dhrsx|DHRSX]]|0.436|
|[[:human genes:m:mllt1|MLLT1]]|0.436|
|[[:human genes:s:slc35b1|SLC35B1]]|0.435|
|[[:human genes:c:cbx3|CBX3]]|0.435|
|[[:human genes:a:alg3|ALG3]]|0.434|
|[[:human genes:d:ddx5|DDX5]]|0.433|
|[[:human genes:m:mbtps1|MBTPS1]]|0.432|
|[[:human genes:a:atp2a2|ATP2A2]]|0.432|
|[[:human genes:c:cdipt|CDIPT]]|0.432|
|[[:human genes:c:c1orf27|C1orf27]]|0.428|
|[[:human genes:m:mrpl15|MRPL15]]|0.427|
|[[:human genes:k:kdsr|KDSR]]|0.427|
|[[:human genes:t:tti1|TTI1]]|0.427|
|[[:human genes:m:mtor|MTOR]]|0.427|
|[[:human genes:o:ost4|OST4]]|0.427|
|[[:human genes:t:tbca|TBCA]]|0.427|
|[[:human genes:u:ufsp2|UFSP2]]|0.426|
|[[:human genes:h:hccs|HCCS]]|0.426|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.426|
|[[:human genes:z:zfx|ZFX]]|0.426|
|[[:human genes:n:nars|NARS]]|0.425|
|[[:human genes:a:alg8|ALG8]]|0.425|
|[[:human genes:c:cept1|CEPT1]]|0.425|
|[[:human genes:a:adsl|ADSL]]|0.425|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.425|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.424|
|[[:human genes:e:elac2|ELAC2]]|0.423|
|[[:human genes:t:tbp|TBP]]|0.422|
|[[:human genes:k:kcmf1|KCMF1]]|0.422|
|[[:human genes:r:rpn1|RPN1]]|0.421|
|[[:human genes:l:lsmd1|LSMD1]]|0.421|
|[[:human genes:d:dhdds|DHDDS]]|0.421|
|[[:human genes:d:dcaf5|DCAF5]]|0.419|
|[[:human genes:s:srp72|SRP72]]|0.419|
|[[:human genes:a:apaf1|APAF1]]|0.418|
|[[:human genes:c:casp9|CASP9]]|0.415|
|[[:human genes:r:rpp21|RPP21]]|0.415|
|[[:human genes:s:sec61g|SEC61G]]|0.414|
|[[:human genes:r:rce1|RCE1]]|0.414|
|[[:human genes:m:mrpl23|MRPL23]]|0.413|
|[[:human genes:p:ppcs|PPCS]]|0.413|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.412|
|[[:human genes:u:uxt|UXT]]|0.412|
|[[:human genes:u:ufc1|UFC1]]|0.411|
|[[:human genes:e:eif1|EIF1]]|0.409|
|[[:human genes:m:mrps14|MRPS14]]|0.409|
|[[:human genes:d:ddost|DDOST]]|0.407|
|[[:human genes:s:ssb|SSB]]|0.407|
|[[:human genes:m:mrps6|MRPS6]]|0.406|
|[[:human genes:u:ube3a|UBE3A]]|0.404|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.403|
|[[:human genes:t:trnt1|TRNT1]]|0.402|
|[[:human genes:t:txnl4b|TXNL4B]]|0.402|
|[[:human genes:s:spcs2|SPCS2]]|0.402|
|[[:human genes:e:eif2b3|EIF2B3]]|0.401|
|[[:human genes:a:atp5d|ATP5D]]|0.4|
|[[:human genes:f:faf2|FAF2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3939
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALG5 Expression in NALM6 Cells: 5.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>