======= ALG6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALG6
  * **<color #00a2e8>Official Name</color>**: ALG6 alpha-1,3-glucosyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29929|29929]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y672|Q9Y672]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALG6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALG6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604566|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the first glucose residue to the growing lipid-linked oligosaccharide precursor of N-linked glycosylation. Mutations in this gene are associated with congenital disorders of glycosylation type Ic. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Alg6 Alg8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity|
|dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity|
|glucosyltransferase activity|
|dolichol-linked oligosaccharide biosynthetic process|
|oligosaccharide-lipid intermediate biosynthetic process|
|protein N-linked glycosylation|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|carbohydrate derivative biosynthetic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp218|A-395 10μM R05 exp218]]|-2.68|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.64|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-2.35|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-2.21|
|[[:results:exp453|B02 10μM R08 exp453]]|-2.12|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-2.03|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.99|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.98|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-1.97|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.95|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.85|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-1.84|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.84|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.84|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.84|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.83|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.82|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.8|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.8|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.79|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.7|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.73|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.78|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.79|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.81|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.86|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.93|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.94|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.96|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.09|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.39|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:alg8|ALG8]]|0.658|
|[[:human genes:d:dhrsx|DHRSX]]|0.623|
|[[:human genes:a:alg5|ALG5]]|0.608|
|[[:human genes:s:sec62|SEC62]]|0.607|
|[[:human genes:d:dpagt1|DPAGT1]]|0.6|
|[[:human genes:m:mbtps2|MBTPS2]]|0.599|
|[[:human genes:s:srd5a3|SRD5A3]]|0.593|
|[[:human genes:p:pmm2|PMM2]]|0.587|
|[[:human genes:a:alg1|ALG1]]|0.579|
|[[:human genes:d:dolk|DOLK]]|0.571|
|[[:human genes:t:triap1|TRIAP1]]|0.56|
|[[:human genes:p:pgm3|PGM3]]|0.556|
|[[:human genes:u:uba5|UBA5]]|0.551|
|[[:human genes:s:srp14|SRP14]]|0.549|
|[[:human genes:t:thg1l|THG1L]]|0.548|
|[[:human genes:t:trmt10a|TRMT10A]]|0.543|
|[[:human genes:d:dpm3|DPM3]]|0.539|
|[[:human genes:s:sec63|SEC63]]|0.537|
|[[:human genes:c:c1orf27|C1orf27]]|0.529|
|[[:human genes:r:rft1|RFT1]]|0.521|
|[[:human genes:d:dnajb11|DNAJB11]]|0.519|
|[[:human genes:d:dnajc3|DNAJC3]]|0.517|
|[[:human genes:t:trmt6|TRMT6]]|0.517|
|[[:human genes:t:tmed10|TMED10]]|0.514|
|[[:human genes:y:yars2|YARS2]]|0.514|
|[[:human genes:s:ssb|SSB]]|0.513|
|[[:human genes:t:trmt61a|TRMT61A]]|0.512|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.511|
|[[:human genes:m:mbtps1|MBTPS1]]|0.511|
|[[:human genes:u:uap1|UAP1]]|0.507|
|[[:human genes:d:dap3|DAP3]]|0.503|
|[[:human genes:u:ube2g2|UBE2G2]]|0.497|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.497|
|[[:human genes:m:mrps6|MRPS6]]|0.496|
|[[:human genes:k:kdsr|KDSR]]|0.495|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.495|
|[[:human genes:g:gfpt1|GFPT1]]|0.492|
|[[:human genes:a:atp5a1|ATP5A1]]|0.491|
|[[:human genes:r:romo1|ROMO1]]|0.49|
|[[:human genes:u:uso1|USO1]]|0.49|
|[[:human genes:p:ppa2|PPA2]]|0.488|
|[[:human genes:a:atp5b|ATP5B]]|0.486|
|[[:human genes:l:lsm10|LSM10]]|0.485|
|[[:human genes:a:atp5o|ATP5O]]|0.478|
|[[:human genes:a:atxn10|ATXN10]]|0.478|
|[[:human genes:r:rpp21|RPP21]]|0.477|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.477|
|[[:human genes:u:ufsp2|UFSP2]]|0.477|
|[[:human genes:a:alg3|ALG3]]|0.476|
|[[:human genes:c:crls1|CRLS1]]|0.475|
|[[:human genes:m:mpdu1|MPDU1]]|0.474|
|[[:human genes:r:rpe|RPE]]|0.471|
|[[:human genes:g:gmppb|GMPPB]]|0.466|
|[[:human genes:c:cbfb|CBFB]]|0.465|
|[[:human genes:a:alg9|ALG9]]|0.463|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.463|
|[[:human genes:p:pdss1|PDSS1]]|0.463|
|[[:human genes:e:eny2|ENY2]]|0.462|
|[[:human genes:u:ufc1|UFC1]]|0.462|
|[[:human genes:s:slc25a26|SLC25A26]]|0.462|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.462|
|[[:human genes:m:manf|MANF]]|0.46|
|[[:human genes:g:gfm1|GFM1]]|0.459|
|[[:human genes:d:dnlz|DNLZ]]|0.459|
|[[:human genes:b:bcs1l|BCS1L]]|0.459|
|[[:human genes:a:atp5d|ATP5D]]|0.458|
|[[:human genes:m:mrpl53|MRPL53]]|0.457|
|[[:human genes:d:dars2|DARS2]]|0.457|
|[[:human genes:p:pggt1b|PGGT1B]]|0.455|
|[[:human genes:r:rpia|RPIA]]|0.454|
|[[:human genes:f:fh|FH]]|0.454|
|[[:human genes:a:alg13|ALG13]]|0.454|
|[[:human genes:t:tpk1|TPK1]]|0.453|
|[[:human genes:m:mrps33|MRPS33]]|0.451|
|[[:human genes:m:mrpl23|MRPL23]]|0.45|
|[[:human genes:d:dohh|DOHH]]|0.45|
|[[:human genes:p:ppcdc|PPCDC]]|0.449|
|[[:human genes:p:pars2|PARS2]]|0.449|
|[[:human genes:l:lars2|LARS2]]|0.444|
|[[:human genes:p:polr3c|POLR3C]]|0.444|
|[[:human genes:t:trmt5|TRMT5]]|0.443|
|[[:human genes:a:adsl|ADSL]]|0.443|
|[[:human genes:r:rnmt|RNMT]]|0.442|
|[[:human genes:a:atp5c1|ATP5C1]]|0.442|
|[[:human genes:d:dpm1|DPM1]]|0.441|
|[[:human genes:t:taz|TAZ]]|0.44|
|[[:human genes:u:ufm1|UFM1]]|0.44|
|[[:human genes:g:gatc|GATC]]|0.44|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.439|
|[[:human genes:m:mrpl21|MRPL21]]|0.439|
|[[:human genes:c:chchd4|CHCHD4]]|0.438|
|[[:human genes:v:vezt|VEZT]]|0.438|
|[[:human genes:m:mrps16|MRPS16]]|0.438|
|[[:human genes:a:atp5j|ATP5J]]|0.438|
|[[:human genes:a:atp5h|ATP5H]]|0.436|
|[[:human genes:w:wbscr16|WBSCR16]]|0.435|
|[[:human genes:m:mrps14|MRPS14]]|0.435|
|[[:human genes:b:bap1|BAP1]]|0.434|
|[[:human genes:e:elac2|ELAC2]]|0.433|
|[[:human genes:r:rptor|RPTOR]]|0.433|
|[[:human genes:u:ube2j1|UBE2J1]]|0.433|
|[[:human genes:r:rtcb|RTCB]]|0.433|
|[[:human genes:t:tmem41b|TMEM41B]]|0.432|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.432|
|[[:human genes:p:pdap1|PDAP1]]|0.429|
|[[:human genes:a:atrx|ATRX]]|0.428|
|[[:human genes:m:mrps5|MRPS5]]|0.428|
|[[:human genes:u:uba3|UBA3]]|0.427|
|[[:human genes:p:ppcs|PPCS]]|0.426|
|[[:human genes:t:tamm41|TAMM41]]|0.426|
|[[:human genes:o:opa1|OPA1]]|0.426|
|[[:human genes:p:ppp6c|PPP6C]]|0.425|
|[[:human genes:d:dad1|DAD1]]|0.424|
|[[:human genes:g:gfm2|GFM2]]|0.423|
|[[:human genes:c:c10orf2|C10orf2]]|0.422|
|[[:human genes:t:timm13|TIMM13]]|0.421|
|[[:human genes:t:tars2|TARS2]]|0.419|
|[[:human genes:p:polg|POLG]]|0.418|
|[[:human genes:n:nars2|NARS2]]|0.418|
|[[:human genes:e:eef1e1|EEF1E1]]|0.417|
|[[:human genes:n:nae1|NAE1]]|0.417|
|[[:human genes:u:urm1|URM1]]|0.416|
|[[:human genes:m:mapk14|MAPK14]]|0.416|
|[[:human genes:u:ufl1|UFL1]]|0.416|
|[[:human genes:t:tti2|TTI2]]|0.415|
|[[:human genes:m:mrpl15|MRPL15]]|0.415|
|[[:human genes:r:rbfa|RBFA]]|0.414|
|[[:human genes:p:pmvk|PMVK]]|0.414|
|[[:human genes:s:stt3a|STT3A]]|0.414|
|[[:human genes:m:med16|MED16]]|0.414|
|[[:human genes:m:mrp63|MRP63]]|0.413|
|[[:human genes:a:atp2a2|ATP2A2]]|0.412|
|[[:human genes:m:mrps21|MRPS21]]|0.411|
|[[:human genes:a:aars|AARS]]|0.41|
|[[:human genes:u:uhrf1|UHRF1]]|0.409|
|[[:human genes:d:dpf2|DPF2]]|0.409|
|[[:human genes:c:cox16|COX16]]|0.409|
|[[:human genes:s:srp68|SRP68]]|0.409|
|[[:human genes:a:alg14|ALG14]]|0.408|
|[[:human genes:u:utp23|UTP23]]|0.408|
|[[:human genes:t:tsen54|TSEN54]]|0.407|
|[[:human genes:c:c17orf89|C17orf89]]|0.406|
|[[:human genes:m:mrps18a|MRPS18A]]|0.406|
|[[:human genes:e:elp3|ELP3]]|0.405|
|[[:human genes:t:tti1|TTI1]]|0.405|
|[[:human genes:t:timm22|TIMM22]]|0.404|
|[[:human genes:e:elp2|ELP2]]|0.402|
|[[:human genes:t:tefm|TEFM]]|0.402|
|[[:human genes:h:hspd1|HSPD1]]|0.401|
|[[:human genes:e:exoc4|EXOC4]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3614
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALG6 Expression in NALM6 Cells: 5.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>