======= ALOX15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALOX15
  * **<color #00a2e8>Official Name</color>**: arachidonate 15-lipoxygenase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=246|246]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16050|P16050]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALOX15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALOX15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/152392|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12- hydroperoxyeicosatetraenoic acid/12-HPETE and 15- hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass. {ECO:0000269|PubMed:17052953, ECO:0000269|PubMed:21831839}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PLAT|
|Lipoxygenase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lipoxin A4 metabolic process|
|hepoxilin A3 synthase activity|
|lipoxin A4 biosynthetic process|
|hepoxilin-epoxide hydrolase activity|
|arachidonate 15-lipoxygenase activity|
|arachidonate 12-lipoxygenase activity|
|regulation of engulfment of apoptotic cell|
|cellular response to interleukin-13|
|response to interleukin-13|
|hepoxilin biosynthetic process|
|hepoxilin metabolic process|
|lipoxin biosynthetic process|
|lipoxin metabolic process|
|regulation of apoptotic cell clearance|
|regulation of peroxisome proliferator activated receptor signaling pathway|
|phosphatidylethanolamine biosynthetic process|
|regulation of phagocytosis, engulfment|
|regulation of membrane invagination|
|positive regulation of heterotypic cell-cell adhesion|
|lipoxygenase pathway|
|phosphatidylethanolamine metabolic process|
|regulation of heterotypic cell-cell adhesion|
|long-chain fatty acid biosynthetic process|
|leukotriene metabolic process|
|apoptotic cell clearance|
|unsaturated fatty acid biosynthetic process|
|negative regulation of adaptive immune response|
|icosanoid biosynthetic process|
|bone mineralization|
|arachidonic acid metabolic process|
|extrinsic component of cytoplasmic side of plasma membrane|
|phosphatidylinositol-4,5-bisphosphate binding|
|lipid droplet|
|cellular response to calcium ion|
|fatty acid derivative biosynthetic process|
|positive regulation of actin filament polymerization|
|biomineral tissue development|
|biomineralization|
|regulation of phagocytosis|
|unsaturated fatty acid metabolic process|
|icosanoid metabolic process|
|long-chain fatty acid metabolic process|
|fatty acid biosynthetic process|
|positive regulation of cell-substrate adhesion|
|positive regulation of protein polymerization|
|iron ion binding|
|negative regulation of immune response|
|response to calcium ion|
|regulation of adaptive immune response|
|regulation of actin filament polymerization|
|fatty acid derivative metabolic process|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|organic hydroxy compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|cellular response to metal ion|
|positive regulation of supramolecular fiber organization|
|regulation of endocytosis|
|glycerophospholipid biosynthetic process|
|regulation of cell-substrate adhesion|
|positive regulation of ERK1 and ERK2 cascade|
|positive regulation of cytoskeleton organization|
|cellular response to inorganic substance|
|glycerolipid biosynthetic process|
|regulation of protein polymerization|
|phospholipid biosynthetic process|
|positive regulation of protein complex assembly|
|positive regulation of cell-cell adhesion|
|response to endoplasmic reticulum stress|
|regulation of actin filament organization|
|ossification|
|regulation of ERK1 and ERK2 cascade|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|glycerophospholipid metabolic process|
|fatty acid metabolic process|
|phagocytosis|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|response to metal ion|
|phospholipid metabolic process|
|regulation of cellular component size|
|glycerolipid metabolic process|
|regulation of actin filament-based process|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|negative regulation of immune system process|
|regulation of protein complex assembly|
|organic hydroxy compound metabolic process|
|wound healing|
|inflammatory response|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|monocarboxylic acid metabolic process|
|response to inorganic substance|
|organophosphate biosynthetic process|
|regulation of cytoskeleton organization|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|response to wounding|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|positive regulation of organelle organization|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulation of MAPK cascade|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|regulation of cellular component biogenesis|
|oxidation-reduction process|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|organic acid metabolic process|
|positive regulation of phosphorylation|
|response to cytokine|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of cellular component organization|
|lipid metabolic process|
|positive regulation of protein modification process|
|regulation of organelle organization|
|defense response|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4814
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALOX15 Expression in NALM6 Cells: -0.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>