======= ANAPC5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANAPC5
  * **<color #00a2e8>Official Name</color>**: anaphase promoting complex subunit 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51433|51433]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UJX4|Q9UJX4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANAPC5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANAPC5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606948|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Apc5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mitotic sister chromatid separation|
|positive regulation of mitotic metaphase/anaphase transition|
|positive regulation of metaphase/anaphase transition of cell cycle|
|positive regulation of chromosome separation|
|positive regulation of mitotic sister chromatid segregation|
|anaphase-promoting complex|
|positive regulation of chromosome segregation|
|protein K11-linked ubiquitination|
|regulation of mitotic metaphase/anaphase transition|
|positive regulation of mitotic nuclear division|
|regulation of metaphase/anaphase transition of cell cycle|
|regulation of mitotic sister chromatid separation|
|regulation of chromosome separation|
|positive regulation of nuclear division|
|regulation of mitotic sister chromatid segregation|
|positive regulation of mitotic cell cycle phase transition|
|regulation of sister chromatid segregation|
|anaphase-promoting complex-dependent catabolic process|
|protein phosphatase binding|
|positive regulation of cell cycle phase transition|
|regulation of chromosome segregation|
|positive regulation of mitotic cell cycle|
|regulation of mitotic nuclear division|
|positive regulation of chromosome organization|
|regulation of nuclear division|
|ubiquitin protein ligase activity|
|positive regulation of cell cycle process|
|protein polyubiquitination|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|regulation of chromosome organization|
|proteasomal protein catabolic process|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|cell division|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|protein catabolic process|
|protein ubiquitination|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|proteolysis|
|regulation of organelle organization|
|cell cycle|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 269/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|9/28|
|blood|14/28|
|bone|8/26|
|breast|13/33|
|central nervous system|20/56|
|cervix|0/4|
|colorectal|6/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|7/16|
|kidney|5/21|
|liver|7/20|
|lung|24/75|
|lymphocyte|6/16|
|ovary|10/26|
|pancreas|8/24|
|peripheral nervous system|8/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|9/24|
|soft tissue|5/9|
|thyroid|0/2|
|upper aerodigestive|8/22|
|urinary tract|8/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 632
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANAPC5 Expression in NALM6 Cells: 8.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>