======= ANKRD27 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANKRD27
  * **<color #00a2e8>Official Name</color>**: ankyrin repeat domain 27
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84079|84079]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96NW4|Q96NW4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANKRD27&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANKRD27|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618957|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (PubMed:16525121, PubMed:18477474). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (PubMed:23104059). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7 (By similarity). Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38 (By similarity). Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1 (PubMed:22705394). Required for the colocalization of VAMP7 and Rab21, probably on TGN sites (PubMed:19745841). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29 (PubMed:24856514). Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). {ECO:0000250|UniProtKB:Q3UMR0, ECO:0000269|PubMed:23104059, ECO:0000269|PubMed:24856514, ECO:0000305|PubMed:16525121, ECO:0000305|PubMed:18477474, ECO:0000305|PubMed:22705394}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank|
|Ank 2|
|VPS9|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of SNARE complex assembly|
|tubular endosome|
|negative regulation of vesicle fusion|
|pigment granule maturation|
|endosome to melanosome transport|
|endosome to pigment granule transport|
|regulation of SNARE complex assembly|
|cellular pigment accumulation|
|pigment accumulation|
|early endosome to late endosome transport|
|vesicle-mediated transport between endosomal compartments|
|retrograde transport, endosome to plasma membrane|
|pigment cell differentiation|
|regulation of vesicle fusion|
|positive regulation of dendrite morphogenesis|
|developmental pigmentation|
|cellular pigmentation|
|SNARE binding|
|positive regulation of dendrite development|
|regulation of dendrite morphogenesis|
|pigmentation|
|transport vesicle|
|vesicle-mediated transport to the plasma membrane|
|melanosome|
|guanyl-nucleotide exchange factor activity|
|late endosome|
|negative regulation of protein complex assembly|
|cytoplasmic vesicle membrane|
|cytosolic transport|
|Rab GTPase binding|
|regulation of dendrite development|
|positive regulation of cell morphogenesis involved in differentiation|
|endosomal transport|
|developmental maturation|
|lysosome|
|early endosome|
|positive regulation of neuron projection development|
|GTPase activator activity|
|regulation of cell morphogenesis involved in differentiation|
|neuron projection|
|positive regulation of neuron differentiation|
|negative regulation of organelle organization|
|positive regulation of cell projection organization|
|positive regulation of GTPase activity|
|regulation of protein complex assembly|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|negative regulation of transport|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|cell part morphogenesis|
|positive regulation of nervous system development|
|positive regulation of cell development|
|regulation of vesicle-mediated transport|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|cell morphogenesis|
|positive regulation of hydrolase activity|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|amide transport|
|establishment of protein localization|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.97|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.81|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.72|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6089
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANKRD27 Expression in NALM6 Cells: 6.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>