======= ANPEP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANPEP
  * **<color #00a2e8>Official Name</color>**: alanyl aminopeptidase, membrane
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=290|290]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15144|P15144]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANPEP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANPEP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/151530|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. {ECO:0000269|PubMed:10605003, ECO:0000269|PubMed:10676659, ECO:0000269|PubMed:11384645, ECO:0000269|PubMed:12473585, ECO:0000269|PubMed:7576235, ECO:0000269|PubMed:8102610, ECO:0000269|PubMed:9056417}. (Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection. {ECO:0000269|PubMed:8105105}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|metalloaminopeptidase activity|
|aminopeptidase activity|
|peptide catabolic process|
|peptide binding|
|metallopeptidase activity|
|endoplasmic reticulum-Golgi intermediate compartment|
|virus receptor activity|
|viral entry into host cell|
|secretory granule membrane|
|entry into host cell|
|entry into host|
|interaction with host|
|viral life cycle|
|signaling receptor activity|
|lysosomal membrane|
|angiogenesis|
|external side of plasma membrane|
|blood vessel morphogenesis|
|neutrophil degranulation|
|blood vessel development|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|vasculature development|
|cardiovascular system development|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|peptide metabolic process|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|tube morphogenesis|
|viral process|
|regulated exocytosis|
|leukocyte mediated immunity|
|symbiotic process|
|cellular amide metabolic process|
|exocytosis|
|interspecies interaction between organisms|
|zinc ion binding|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|leukocyte activation|
|secretion by cell|
|export from cell|
|organonitrogen compound catabolic process|
|cell activation|
|immune effector process|
|secretion|
|proteolysis|
|extracellular space|
|organic substance catabolic process|
|cellular catabolic process|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.49|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4220
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.07 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANPEP Expression in NALM6 Cells: -1.07'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>