======= ANXA5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANXA5
  * **<color #00a2e8>Official Name</color>**: annexin A5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=308|308]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08758|P08758]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANXA5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANXA5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/131230|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Annexin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of prolactin secretion|
|endothelial microparticle|
|cellular response to lead ion|
|phospholipase inhibitor activity|
|cellular response to gonadotropin-releasing hormone|
|response to gonadotropin-releasing hormone|
|calcium transmembrane transporter activity, phosphorylative mechanism|
|regulation of flagellated sperm motility|
|regulation of cilium-dependent cell motility|
|response to lead ion|
|response to thyroid hormone|
|peptide hormone binding|
|negative regulation of peptide hormone secretion|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|calcium-dependent phospholipid binding|
|negative regulation of sequestering of calcium ion|
|receptor tyrosine kinase binding|
|negative regulation of hormone secretion|
|negative regulation of wound healing|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|negative regulation of response to wounding|
|intracellular|
|phospholipid binding|
|regulation of sequestering of calcium ion|
|platelet degranulation|
|negative regulation of protein secretion|
|regulation of wound healing|
|negative regulation of peptide secretion|
|response to calcium ion|
|regulation of reproductive process|
|regulation of response to wounding|
|heparin binding|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|cellular response to metal ion|
|calcium ion transmembrane transport|
|negative regulation of secretion by cell|
|regulation of peptide hormone secretion|
|cellular response to inorganic substance|
|negative regulation of secretion|
|calcium ion transport|
|cellular response to peptide hormone stimulus|
|regulation of hormone secretion|
|blood coagulation|
|coagulation|
|divalent metal ion transport|
|hemostasis|
|divalent inorganic cation transport|
|cellular response to peptide|
|collagen-containing extracellular matrix|
|negative regulation of response to external stimulus|
|response to metal ion|
|response to peptide hormone|
|external side of plasma membrane|
|focal adhesion|
|regulation of protein secretion|
|response to peptide|
|wound healing|
|negative regulation of transport|
|regulation of peptide secretion|
|regulation of body fluid levels|
|response to inorganic substance|
|regulation of hormone levels|
|inorganic cation transmembrane transport|
|response to wounding|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|metal ion transport|
|positive regulation of apoptotic process|
|inorganic ion transmembrane transport|
|positive regulation of programmed cell death|
|cellular response to nitrogen compound|
|positive regulation of cell death|
|regulated exocytosis|
|regulation of protein transport|
|calcium ion binding|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of secretion|
|cation transport|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|ion transmembrane transport|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|response to organonitrogen compound|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|regulation of response to external stimulus|
|secretion|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|transmembrane transport|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|regulation of cell death|
|regulation of transport|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.75|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.75|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|1.97|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|2.12|
|[[:results:exp16|DABN 2μM R00 exp16]]|2.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8351
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANXA5 Expression in NALM6 Cells: 5.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>