======= AOC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AOC1
  * **<color #00a2e8>Official Name</color>**: amine oxidase copper containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26|26]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19801|P19801]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AOC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AOC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/104610|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cu amine oxidN2|
|Cu amine oxid|
|Cu amine oxidN3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|diamine oxidase activity|
|cellular response to copper ion starvation|
|propane-1,3-diamine oxidase activity|
|response to azide|
|methylputrescine oxidase activity|
|histamine oxidase activity|
|cellular response to azide|
|response to copper ion starvation|
|cellular response to heparin|
|response to heparin|
|primary amine oxidase activity|
|response to anticoagulant|
|cellular response to histamine|
|quinone binding|
|response to histamine|
|cellular response to copper ion|
|response to copper ion|
|copper ion binding|
|drug binding|
|specific granule lumen|
|amine metabolic process|
|peroxisome|
|bicellular tight junction|
|cellular response to ammonium ion|
|xenobiotic metabolic process|
|cellular response to starvation|
|heparin binding|
|response to ammonium ion|
|cellular response to xenobiotic stimulus|
|cellular response to metal ion|
|response to starvation|
|cellular response to inorganic substance|
|cellular response to nutrient levels|
|cellular response to extracellular stimulus|
|protein-containing complex binding|
|response to xenobiotic stimulus|
|response to antibiotic|
|cellular response to external stimulus|
|response to metal ion|
|cellular response to drug|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|response to nutrient levels|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|response to extracellular stimulus|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|myeloid leukocyte activation|
|cellular response to organonitrogen compound|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular response to nitrogen compound|
|regulated exocytosis|
|calcium ion binding|
|leukocyte mediated immunity|
|exocytosis|
|zinc ion binding|
|protein homodimerization activity|
|response to organic cyclic compound|
|leukocyte activation|
|oxidation-reduction process|
|response to organonitrogen compound|
|secretion by cell|
|response to drug|
|export from cell|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|secretion|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|extracellular space|
|cellular response to stress|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3762
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AOC1 Expression in NALM6 Cells: 0.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>