======= AP3D1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AP3D1
  * **<color #00a2e8>Official Name</color>**: adaptor related protein complex 3 subunit delta 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8943|8943]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14617|O14617]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AP3D1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AP3D1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607246|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a subunit of the AP3 adaptor-like complex, which is not clathrin-associated, but is associated with the golgi region, as well as more peripheral structures. The AP-3 complex facilitates the budding of vesicles from the golgi membrane, and may be directly involved in trafficking to lysosomes. This subunit is implicated in intracellular biogenesis and trafficking of pigment granules, and possibly platelet dense granules and neurotransmitter vesicles. Defects in this gene are a cause of a new type of Hermansky-Pudlak syndrome. [provided by RefSeq, Feb 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). {ECO:0000250|UniProtKB:O54774, ECO:0000269|PubMed:26744459}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Adaptin N|
|BLVR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|presynaptic endosome|
|synaptic vesicle budding from endosome|
|positive regulation of NK T cell differentiation|
|synaptic vesicle membrane organization|
|synaptic vesicle recycling via endosome|
|regulation of sequestering of zinc ion|
|regulation of NK T cell differentiation|
|synaptic vesicle endosomal processing|
|antigen processing and presentation, exogenous lipid antigen via MHC class Ib|
|neurotransmitter receptor transport, postsynaptic endosome to lysosome|
|antigen processing and presentation of lipid antigen via MHC class Ib|
|synaptic vesicle budding|
|AP-3 adaptor complex|
|pigment granule maturation|
|endosome to melanosome transport|
|endosome to pigment granule transport|
|pigment accumulation|
|cellular pigment accumulation|
|Golgi to vacuole transport|
|antigen processing and presentation via MHC class Ib|
|anterograde synaptic vesicle transport|
|synaptic vesicle cytoskeletal transport|
|synaptic vesicle transport along microtubule|
|melanosome organization|
|pigment granule organization|
|pigment cell differentiation|
|neurotransmitter receptor transport|
|synaptic vesicle transport|
|protein targeting to vacuole|
|protein localization to lysosome|
|developmental pigmentation|
|synaptic vesicle localization|
|anterograde axonal transport|
|vesicle transport along microtubule|
|positive regulation of alpha-beta T cell differentiation|
|establishment of protein localization to vacuole|
|cellular pigmentation|
|terminal bouton|
|vesicle cytoskeletal trafficking|
|synaptic vesicle recycling|
|axonal transport|
|axon cytoplasm|
|positive regulation of alpha-beta T cell activation|
|protein localization to vacuole|
|regulation of alpha-beta T cell differentiation|
|axo-dendritic transport|
|organelle transport along microtubule|
|positive regulation of T cell differentiation|
|postsynapse|
|pigmentation|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|vesicle budding from membrane|
|post-Golgi vesicle-mediated transport|
|lysosomal transport|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|regulation of T cell differentiation|
|vacuolar transport|
|positive regulation of leukocyte differentiation|
|transport along microtubule|
|regulation of lymphocyte differentiation|
|establishment of vesicle localization|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|antigen processing and presentation of exogenous antigen|
|vesicle localization|
|positive regulation of hemopoiesis|
|positive regulation of T cell activation|
|endosome membrane|
|antigen processing and presentation|
|positive regulation of leukocyte cell-cell adhesion|
|endosomal transport|
|developmental maturation|
|positive regulation of cell-cell adhesion|
|protein-containing complex localization|
|microtubule-based movement|
|regulation of leukocyte differentiation|
|regulation of leukocyte cell-cell adhesion|
|lysosomal membrane|
|vesicle organization|
|regulation of T cell activation|
|glutamatergic synapse|
|protein targeting|
|positive regulation of lymphocyte activation|
|establishment of organelle localization|
|Golgi vesicle transport|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|endomembrane system organization|
|establishment of protein localization to organelle|
|regulation of hemopoiesis|
|protein localization to membrane|
|regulation of lymphocyte activation|
|organelle localization|
|regulation of leukocyte activation|
|Golgi membrane|
|regulation of cell activation|
|microtubule-based process|
|regulation of cell adhesion|
|protein localization to organelle|
|ion homeostasis|
|membrane organization|
|positive regulation of cell differentiation|
|Golgi apparatus|
|intracellular protein transport|
|chemical homeostasis|
|positive regulation of immune system process|
|positive regulation of developmental process|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|homeostatic process|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2.17|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-2.15|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.91|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.72|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.8|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.81|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.2|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rabl6|RABL6]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3287
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AP3D1 Expression in NALM6 Cells: 7.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>