======= APBB1IP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APBB1IP
  * **<color #00a2e8>Official Name</color>**: amyloid beta precursor protein binding family B member 1 interacting protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54518|54518]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z5R6|Q7Z5R6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APBB1IP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APBB1IP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609036|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin- induced promoter activities through AP1 and SRE. Mediates Rap1- induced adhesion. {ECO:0000269|PubMed:14530287, ECO:0000269|PubMed:15469846}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RA|
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|
|T cell activation involved in immune response|
|lymphocyte activation involved in immune response|
|T cell receptor complex|
|lamellipodium|
|T cell activation|
|cytoskeleton|
|lymphocyte activation|
|positive regulation of cell adhesion|
|focal adhesion|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell adhesion|
|leukocyte activation|
|cell activation|
|immune effector process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-1.94|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.86|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-1.83|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.82|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.76|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.73|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.72|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18787
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APBB1IP Expression in NALM6 Cells: 6.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>