======= APCS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APCS
  * **<color #00a2e8>Official Name</color>**: amyloid P component, serum
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=325|325]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02743|P02743]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APCS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APCS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/104770|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pentaxin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|modulation by host of viral catalytic activity|
|negative regulation by host of symbiont catalytic activity|
|modulation by host of viral exo-alpha-sialidase activity|
|negative regulation by host of viral glycoprotein metabolic process|
|negative regulation of exo-alpha-sialidase activity|
|negative regulation by host of viral exo-alpha-sialidase activity|
|modulation by host of viral glycoprotein metabolic process|
|modulation by host of viral molecular function|
|modulation by host of symbiont catalytic activity|
|regulation of exo-alpha-sialidase activity|
|negative regulation of catalytic activity in other organism involved in symbiotic interaction|
|modulation of catalytic activity in other organism involved in symbiotic interaction|
|negative regulation of monocyte differentiation|
|negative regulation by host of symbiont molecular function|
|modulation by host of symbiont molecular function|
|complement component C1q binding|
|negative regulation of molecular function in other organism|
|negative regulation of molecular function in other organism involved in symbiotic interaction|
|modulation of molecular function in other organism involved in symbiotic interaction|
|modulation of molecular function in other organism|
|negative regulation by host of viral process|
|virion binding|
|negative regulation of acute inflammatory response|
|negative regulation of glycoprotein metabolic process|
|low-density lipoprotein particle binding|
|chaperone-mediated protein complex assembly|
|regulation of monocyte differentiation|
|negative regulation of viral entry into host cell|
|modulation by host of viral process|
|regulation of viral entry into host cell|
|acute-phase response|
|regulation of acute inflammatory response|
|regulation of glycoprotein metabolic process|
|negative regulation of myeloid leukocyte differentiation|
|acute inflammatory response|
|modification by host of symbiont morphology or physiology|
|negative regulation of wound healing|
|interaction with symbiont|
|negative regulation of myeloid cell differentiation|
|negative regulation of viral life cycle|
|negative regulation of response to wounding|
|negative regulation of viral process|
|negative regulation of leukocyte differentiation|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|regulation of myeloid leukocyte differentiation|
|unfolded protein binding|
|negative regulation of hemopoiesis|
|negative regulation of inflammatory response|
|regulation of wound healing|
|blood microparticle|
|regulation of viral life cycle|
|modification of morphology or physiology of other organism|
|complement activation, classical pathway|
|regulation of response to wounding|
|humoral immune response mediated by circulating immunoglobulin|
|carbohydrate binding|
|complement activation|
|regulation of viral process|
|immunoglobulin mediated immune response|
|negative regulation of defense response|
|B cell mediated immunity|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of myeloid cell differentiation|
|protein folding|
|lymphocyte mediated immunity|
|regulation of leukocyte differentiation|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of inflammatory response|
|humoral immune response|
|negative regulation of response to external stimulus|
|collagen-containing extracellular matrix|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|negative regulation of hydrolase activity|
|inflammatory response|
|adaptive immune response|
|activation of immune response|
|negative regulation of cell differentiation|
|calcium ion binding|
|regulation of defense response|
|leukocyte mediated immunity|
|innate immune response|
|regulation of multi-organism process|
|symbiotic process|
|negative regulation of catalytic activity|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|positive regulation of immune response|
|negative regulation of developmental process|
|defense response to other organism|
|identical protein binding|
|immune effector process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|protein-containing complex assembly|
|extracellular space|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.487|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7894
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APCS Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>