======= APLN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APLN
  * **<color #00a2e8>Official Name</color>**: apelin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8862|8862]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULZ1|Q9ULZ1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APLN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APLN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300297|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a peptide that functions as an endogenous ligand for the G-protein coupled apelin receptor. The encoded preproprotein is proteolytically processed into biologically active C-terminal peptide fragments. These peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1. [provided by RefSeq, Feb 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Endogenous ligand for the apelin receptor (APLNR) (PubMed:10525157). Drives internalization of the apelin receptor (By similarity). Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (By similarity). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (By similarity). Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates (By similarity). Plays a role in early coronary blood vessels formation (By similarity). Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity). May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior (By similarity). {ECO:0000250|UniProtKB:Q4TTN8, ECO:0000250|UniProtKB:Q9R0R3, ECO:0000250|UniProtKB:Q9R0R4, ECO:0000269|PubMed:10525157}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of corticotropin-releasing hormone secretion|
|positive regulation of G protein-coupled receptor internalization|
|apelin receptor binding|
|regulation of corticotropin-releasing hormone secretion|
|apelin receptor signaling pathway|
|regulation of G protein-coupled receptor internalization|
|positive regulation of corticotropin secretion|
|regulation of corticotropin secretion|
|negative regulation of vasoconstriction|
|drinking behavior|
|positive regulation of heat generation|
|regulation of heat generation|
|positive regulation of vascular endothelial cell proliferation|
|negative regulation of fibroblast growth factor receptor signaling pathway|
|negative regulation of vascular smooth muscle cell proliferation|
|regulation of vascular endothelial cell proliferation|
|regulation of respiratory gaseous exchange|
|positive regulation of receptor internalization|
|regulation of the force of heart contraction|
|regulation of fibroblast growth factor receptor signaling pathway|
|positive regulation of pri-miRNA transcription by RNA polymerase II|
|negative regulation of blood circulation|
|positive regulation of heart contraction|
|positive regulation of neurotransmitter transport|
|regulation of pri-miRNA transcription by RNA polymerase II|
|regulation of endocrine process|
|coronary vasculature development|
|negative regulation of smooth muscle cell proliferation|
|negative regulation of blood pressure|
|lactation|
|regulation of vascular smooth muscle cell proliferation|
|positive regulation of receptor-mediated endocytosis|
|regulation of receptor internalization|
|regulation of vasoconstriction|
|positive regulation of blood vessel diameter|
|positive regulation of blood circulation|
|body fluid secretion|
|feeding behavior|
|positive regulation of endothelial cell proliferation|
|positive regulation of peptide hormone secretion|
|hormone activity|
|regulation of receptor-mediated endocytosis|
|positive regulation of endocytosis|
|mammary gland development|
|positive regulation of hormone secretion|
|regulation of endothelial cell proliferation|
|regulation of smooth muscle cell proliferation|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|regulation of G protein-coupled receptor signaling pathway|
|regulation of neurotransmitter transport|
|negative regulation of cellular response to growth factor stimulus|
|gastrulation|
|vascular process in circulatory system|
|regulation of blood pressure|
|positive regulation of epithelial cell proliferation|
|regulation of endocytosis|
|regulation of peptide hormone secretion|
|regulation of heart contraction|
|regulation of hormone secretion|
|regulation of cellular response to growth factor stimulus|
|regulation of blood circulation|
|positive regulation of peptide secretion|
|angiogenesis|
|regulation of epithelial cell proliferation|
|signaling receptor binding|
|blood circulation|
|circulatory system process|
|positive regulation of secretion by cell|
|blood vessel morphogenesis|
|gland development|
|positive regulation of secretion|
|blood vessel development|
|regulation of peptide secretion|
|regulation of body fluid levels|
|vasculature development|
|regulation of anatomical structure size|
|cardiovascular system development|
|heart development|
|regulation of hormone levels|
|regulation of vesicle-mediated transport|
|embryonic morphogenesis|
|behavior|
|regulation of system process|
|tube morphogenesis|
|negative regulation of cell population proliferation|
|perinuclear region of cytoplasm|
|regulation of peptide transport|
|regulation of secretion by cell|
|regulation of secretion|
|tube development|
|circulatory system development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|embryo development|
|positive regulation of transport|
|positive regulation of phosphorylation|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15193
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APLN Expression in NALM6 Cells: 0.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>