======= APOA4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APOA4
  * **<color #00a2e8>Official Name</color>**: apolipoprotein A4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=337|337]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P06727|P06727]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APOA4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APOA4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/107690|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon.  The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles.  Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Apolipoprotein|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to lipid hydroperoxide|
|negative regulation of plasma lipoprotein oxidation|
|regulation of plasma lipoprotein oxidation|
|response to stilbenoid|
|phosphatidylcholine-sterol O-acyltransferase activator activity|
|positive regulation of triglyceride catabolic process|
|regulation of intestinal lipid absorption|
|regulation of intestinal cholesterol absorption|
|chylomicron remodeling|
|regulation of intestinal absorption|
|positive regulation of cholesterol esterification|
|positive regulation of lipoprotein lipase activity|
|chylomicron assembly|
|very-low-density lipoprotein particle remodeling|
|positive regulation of triglyceride lipase activity|
|regulation of cholesterol esterification|
|regulation of triglyceride catabolic process|
|phospholipid efflux|
|chylomicron|
|removal of superoxide radicals|
|high-density lipoprotein particle assembly|
|triglyceride-rich lipoprotein particle remodeling|
|cellular response to superoxide|
|cellular response to oxygen radical|
|reverse cholesterol transport|
|response to superoxide|
|high-density lipoprotein particle remodeling|
|response to oxygen radical|
|antioxidant activity|
|cholesterol transfer activity|
|positive regulation of triglyceride metabolic process|
|innate immune response in mucosa|
|positive regulation of fatty acid biosynthetic process|
|very-low-density lipoprotein particle|
|response to hydroperoxide|
|regulation of lipoprotein lipase activity|
|high-density lipoprotein particle|
|cholesterol efflux|
|positive regulation of lipid catabolic process|
|plasma lipoprotein particle assembly|
|triglyceride catabolic process|
|hydrogen peroxide catabolic process|
|positive regulation of steroid metabolic process|
|protein-lipid complex remodeling|
|plasma lipoprotein particle remodeling|
|phosphatidylcholine binding|
|protein-containing complex remodeling|
|mucosal immune response|
|protein-lipid complex assembly|
|lipid transporter activity|
|organ or tissue specific immune response|
|positive regulation of fatty acid metabolic process|
|regulation of triglyceride metabolic process|
|acylglycerol catabolic process|
|neutral lipid catabolic process|
|triglyceride homeostasis|
|acylglycerol homeostasis|
|hydrogen peroxide metabolic process|
|superoxide metabolic process|
|regulation of digestive system process|
|cholesterol biosynthetic process|
|secondary alcohol biosynthetic process|
|plasma lipoprotein particle organization|
|regulation of cholesterol transport|
|regulation of fatty acid biosynthetic process|
|regulation of sterol transport|
|protein-lipid complex subunit organization|
|sterol biosynthetic process|
|cholesterol binding|
|leukocyte cell-cell adhesion|
|antibiotic catabolic process|
|glycerolipid catabolic process|
|regulation of lipid catabolic process|
|cholesterol transport|
|copper ion binding|
|cofactor catabolic process|
|sterol transport|
|positive regulation of lipase activity|
|regulation of plasma lipoprotein particle levels|
|triglyceride metabolic process|
|phosphatidylcholine metabolic process|
|cholesterol homeostasis|
|positive regulation of lipid biosynthetic process|
|sterol homeostasis|
|regulation of fatty acid metabolic process|
|cellular oxidant detoxification|
|phospholipid transport|
|regulation of lipase activity|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|cellular detoxification|
|antibiotic metabolic process|
|retinoid metabolic process|
|phospholipid binding|
|regulation of lipid transport|
|diterpenoid metabolic process|
|reactive oxygen species metabolic process|
|alcohol biosynthetic process|
|regulation of steroid metabolic process|
|cholesterol metabolic process|
|lipoprotein metabolic process|
|terpenoid metabolic process|
|organophosphate ester transport|
|steroid biosynthetic process|
|detoxification|
|secondary alcohol metabolic process|
|cellular response to reactive oxygen species|
|lipid homeostasis|
|sterol metabolic process|
|regulation of lipid localization|
|positive regulation of small molecule metabolic process|
|organic hydroxy compound transport|
|isoprenoid metabolic process|
|positive regulation of lipid metabolic process|
|blood microparticle|
|drug catabolic process|
|lipid binding|
|regulation of cellular ketone metabolic process|
|organic hydroxy compound biosynthetic process|
|regulation of lipid biosynthetic process|
|ammonium ion metabolic process|
|cellular lipid catabolic process|
|response to reactive oxygen species|
|cellular response to toxic substance|
|cellular response to oxidative stress|
|early endosome|
|steroid metabolic process|
|lipid transport|
|lipid catabolic process|
|endoplasmic reticulum lumen|
|glycerophospholipid metabolic process|
|alcohol metabolic process|
|lipid localization|
|collagen-containing extracellular matrix|
|positive regulation of cellular catabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|extracellular structure organization|
|response to oxidative stress|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|cofactor metabolic process|
|organic hydroxy compound metabolic process|
|organic anion transport|
|drug metabolic process|
|cell-cell adhesion|
|response to toxic substance|
|response to inorganic substance|
|lipid biosynthetic process|
|anion transport|
|regulation of system process|
|small molecule biosynthetic process|
|cell surface|
|negative regulation of cellular component organization|
|innate immune response|
|positive regulation of hydrolase activity|
|regulation of cellular catabolic process|
|protein homodimerization activity|
|organophosphate metabolic process|
|response to organic cyclic compound|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|cellular lipid metabolic process|
|regulation of catabolic process|
|cellular response to oxygen-containing compound|
|identical protein binding|
|chemical homeostasis|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|regulation of hydrolase activity|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|ion transport|
|positive regulation of catalytic activity|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|extracellular space|
|homeostatic process|
|cellular response to stress|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-2.12|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-2.09|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|1.78|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.81|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17783
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APOA4 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>