======= APOA5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APOA5
  * **<color #00a2e8>Official Name</color>**: apolipoprotein A5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=116519|116519]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6Q788|Q6Q788]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APOA5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APOA5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606368|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. {ECO:0000250, ECO:0000269|PubMed:11588264, ECO:0000269|PubMed:12899628, ECO:0000269|PubMed:15528295}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Apolipoprotein|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lipase activator activity|
|positive regulation of very-low-density lipoprotein particle remodeling|
|lipoprotein particle receptor binding|
|lipoprotein lipase activator activity|
|regulation of very-low-density lipoprotein particle remodeling|
|phosphatidylcholine-sterol O-acyltransferase activator activity|
|lipase binding|
|positive regulation of triglyceride catabolic process|
|regulation of intestinal cholesterol absorption|
|regulation of intestinal lipid absorption|
|positive regulation of lipoprotein lipase activity|
|positive regulation of cholesterol esterification|
|regulation of intestinal absorption|
|positive regulation of triglyceride lipase activity|
|very-low-density lipoprotein particle remodeling|
|regulation of cholesterol esterification|
|regulation of triglyceride catabolic process|
|phospholipid efflux|
|high-density lipoprotein particle assembly|
|chylomicron|
|triglyceride-rich lipoprotein particle remodeling|
|low-density lipoprotein particle|
|cholesterol transfer activity|
|positive regulation of triglyceride metabolic process|
|positive regulation of fatty acid biosynthetic process|
|very-low-density lipoprotein particle|
|low-density lipoprotein particle receptor binding|
|regulation of lipoprotein lipase activity|
|high-density lipoprotein particle|
|cholesterol efflux|
|positive regulation of lipid catabolic process|
|plasma lipoprotein particle assembly|
|positive regulation of steroid metabolic process|
|triglyceride catabolic process|
|plasma lipoprotein particle remodeling|
|protein-lipid complex remodeling|
|phosphatidylcholine binding|
|protein-containing complex remodeling|
|protein-lipid complex assembly|
|positive regulation of fatty acid metabolic process|
|triglyceride homeostasis|
|neutral lipid catabolic process|
|acylglycerol catabolic process|
|regulation of triglyceride metabolic process|
|acylglycerol homeostasis|
|regulation of digestive system process|
|cholesterol biosynthetic process|
|secondary alcohol biosynthetic process|
|plasma lipoprotein particle organization|
|regulation of fatty acid biosynthetic process|
|regulation of cholesterol transport|
|enzyme activator activity|
|regulation of sterol transport|
|protein-lipid complex subunit organization|
|sterol biosynthetic process|
|cholesterol binding|
|positive regulation of receptor-mediated endocytosis|
|glycerolipid catabolic process|
|cholesterol transport|
|regulation of lipid catabolic process|
|tissue regeneration|
|sterol transport|
|positive regulation of lipase activity|
|regulation of plasma lipoprotein particle levels|
|triglyceride metabolic process|
|phosphatidylcholine metabolic process|
|cholesterol homeostasis|
|positive regulation of lipid biosynthetic process|
|sterol homeostasis|
|regulation of fatty acid metabolic process|
|phospholipid transport|
|regulation of lipase activity|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|regulation of receptor-mediated endocytosis|
|positive regulation of endocytosis|
|phospholipid binding|
|regulation of lipid transport|
|alcohol biosynthetic process|
|regulation of steroid metabolic process|
|cholesterol metabolic process|
|lipoprotein metabolic process|
|organophosphate ester transport|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|lipid homeostasis|
|sterol metabolic process|
|positive regulation of small molecule metabolic process|
|regulation of lipid localization|
|organic hydroxy compound transport|
|positive regulation of lipid metabolic process|
|lipid binding|
|regeneration|
|heparin binding|
|regulation of cellular ketone metabolic process|
|organic hydroxy compound biosynthetic process|
|regulation of lipid biosynthetic process|
|ammonium ion metabolic process|
|cellular lipid catabolic process|
|regulation of endocytosis|
|steroid metabolic process|
|lipid transport|
|lipid catabolic process|
|endoplasmic reticulum lumen|
|glycerophospholipid metabolic process|
|alcohol metabolic process|
|lipid localization|
|enzyme binding|
|post-translational protein modification|
|positive regulation of cellular catabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|extracellular structure organization|
|developmental growth|
|growth|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|organic hydroxy compound metabolic process|
|organic anion transport|
|wound healing|
|regulation of vesicle-mediated transport|
|response to wounding|
|lipid biosynthetic process|
|anion transport|
|small molecule biosynthetic process|
|regulation of system process|
|positive regulation of hydrolase activity|
|regulation of cellular catabolic process|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|positive regulation of transport|
|regulation of catabolic process|
|chemical homeostasis|
|positive regulation of cellular component organization|
|lipid metabolic process|
|regulation of hydrolase activity|
|organic cyclic compound biosynthetic process|
|ion transport|
|positive regulation of catalytic activity|
|protein-containing complex assembly|
|extracellular space|
|homeostatic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|protein-containing complex subunit organization|
|regulation of transport|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13530
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APOA5 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>