======= APOB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APOB
  * **<color #00a2e8>Official Name</color>**: apolipoprotein B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=338|338]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04114|P04114]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APOB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APOB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/107730|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ApoB100 C|
|Vitellogenin N|
|DUF1081|
|DUF1943|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chylomicron remnant|
|mature chylomicron|
|vesicle lumen|
|triglyceride mobilization|
|intermediate-density lipoprotein particle|
|very-low-density lipoprotein particle clearance|
|lipase binding|
|positive regulation of cholesterol storage|
|triglyceride-rich lipoprotein particle clearance|
|chylomicron remnant clearance|
|chylomicron remodeling|
|chylomicron assembly|
|response to selenium ion|
|very-low-density lipoprotein particle assembly|
|lipoprotein localization|
|lipoprotein transport|
|chylomicron|
|low-density lipoprotein particle remodeling|
|triglyceride-rich lipoprotein particle remodeling|
|regulation of cholesterol storage|
|low-density lipoprotein particle|
|lipoprotein catabolic process|
|endocytic vesicle lumen|
|positive regulation of macrophage derived foam cell differentiation|
|endosome lumen|
|cholesterol transfer activity|
|very-low-density lipoprotein particle|
|low-density lipoprotein particle receptor binding|
|positive regulation of lipid storage|
|cellular response to prostaglandin stimulus|
|high-density lipoprotein particle|
|cholesterol efflux|
|low-density lipoprotein particle clearance|
|plasma lipoprotein particle assembly|
|triglyceride catabolic process|
|smooth endoplasmic reticulum|
|plasma lipoprotein particle remodeling|
|protein-lipid complex remodeling|
|regulation of macrophage derived foam cell differentiation|
|protein-containing complex remodeling|
|endoplasmic reticulum exit site|
|protein-lipid complex assembly|
|response to prostaglandin|
|clathrin-coated endocytic vesicle membrane|
|neutral lipid catabolic process|
|acylglycerol catabolic process|
|plasma lipoprotein particle clearance|
|regulation of cholesterol biosynthetic process|
|regulation of sterol biosynthetic process|
|plasma lipoprotein particle organization|
|regulation of lipid storage|
|protein-lipid complex subunit organization|
|glycerolipid catabolic process|
|cholesterol transport|
|cellular response to fatty acid|
|regulation of cholesterol metabolic process|
|artery morphogenesis|
|sterol transport|
|sperm motility|
|flagellated sperm motility|
|regulation of plasma lipoprotein particle levels|
|regulation of alcohol biosynthetic process|
|triglyceride metabolic process|
|cholesterol homeostasis|
|sterol homeostasis|
|positive regulation of lipid localization|
|response to fatty acid|
|artery development|
|regulation of steroid biosynthetic process|
|post-embryonic development|
|lipoprotein biosynthetic process|
|lysosomal lumen|
|cilium or flagellum-dependent cell motility|
|cilium-dependent cell motility|
|acylglycerol metabolic process|
|toll-like receptor signaling pathway|
|neutral lipid metabolic process|
|retinoid metabolic process|
|phospholipid binding|
|diterpenoid metabolic process|
|regulation of steroid metabolic process|
|cholesterol metabolic process|
|lipoprotein metabolic process|
|terpenoid metabolic process|
|pattern recognition receptor signaling pathway|
|secondary alcohol metabolic process|
|lipid homeostasis|
|sterol metabolic process|
|response to estradiol|
|isoprenoid metabolic process|
|organic hydroxy compound transport|
|regulation of lipid localization|
|fertilization|
|heparin binding|
|response to carbohydrate|
|regulation of lipid biosynthetic process|
|cellular lipid catabolic process|
|cellular response to acid chemical|
|endosome membrane|
|innate immune response-activating signal transduction|
|receptor-mediated endocytosis|
|cellular response to tumor necrosis factor|
|early endosome|
|activation of innate immune response|
|steroid metabolic process|
|response to tumor necrosis factor|
|response to virus|
|lipid transport|
|lipid catabolic process|
|endoplasmic reticulum lumen|
|response to lipopolysaccharide|
|alcohol metabolic process|
|lipid localization|
|response to molecule of bacterial origin|
|positive regulation of innate immune response|
|response to acid chemical|
|positive regulation of response to biotic stimulus|
|post-translational protein modification|
|neuronal cell body|
|in utero embryonic development|
|leukocyte migration|
|glycerolipid metabolic process|
|extracellular structure organization|
|regulation of lipid metabolic process|
|blood vessel morphogenesis|
|regulation of small molecule metabolic process|
|regulation of innate immune response|
|organic hydroxy compound metabolic process|
|positive regulation of defense response|
|blood vessel development|
|positive regulation of multi-organism process|
|vasculature development|
|cardiovascular system development|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|response to inorganic substance|
|spermatogenesis|
|endocytosis|
|immune response-activating signal transduction|
|male gamete generation|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|activation of immune response|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|import into cell|
|protein catabolic process|
|intracellular membrane-bounded organelle|
|response to bacterium|
|gamete generation|
|regulation of defense response|
|regulation of multi-organism process|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|membrane organization|
|response to lipid|
|positive regulation of immune response|
|circulatory system development|
|response to hormone|
|response to organic cyclic compound|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|multi-organism reproductive process|
|cellular response to cytokine stimulus|
|macromolecule catabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|response to cytokine|
|chemical homeostasis|
|positive regulation of immune system process|
|regulation of immune response|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|peptide transport|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|amide transport|
|extracellular space|
|establishment of protein localization|
|homeostatic process|
|regulation of immune system process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14236
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.44 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APOB Expression in NALM6 Cells: -0.44'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>