======= APOC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APOC2
  * **<color #00a2e8>Official Name</color>**: apolipoprotein C2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=344|344]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02655|P02655]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APOC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APOC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608083|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL. {ECO:0000269|PubMed:2209608, ECO:0000303|PubMed:22304839}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Apo-CII|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of phospholipid catabolic process|
|positive regulation of very-low-density lipoprotein particle remodeling|
|lipoprotein lipase activator activity|
|negative regulation of very-low-density lipoprotein particle clearance|
|regulation of very-low-density lipoprotein particle clearance|
|regulation of very-low-density lipoprotein particle remodeling|
|intermediate-density lipoprotein particle|
|regulation of phospholipid catabolic process|
|lipase inhibitor activity|
|phospholipase activator activity|
|positive regulation of triglyceride catabolic process|
|triglyceride-rich lipoprotein particle clearance|
|negative regulation of lipoprotein particle clearance|
|chylomicron remnant clearance|
|spherical high-density lipoprotein particle|
|positive regulation of lipoprotein lipase activity|
|chylomicron remodeling|
|very-low-density lipoprotein particle remodeling|
|positive regulation of triglyceride lipase activity|
|chylomicron assembly|
|high-density lipoprotein particle clearance|
|lipoprotein localization|
|negative regulation of cholesterol transport|
|phospholipid efflux|
|regulation of triglyceride catabolic process|
|negative regulation of sterol transport|
|lipoprotein transport|
|chylomicron|
|triglyceride-rich lipoprotein particle remodeling|
|low-density lipoprotein particle|
|phospholipase binding|
|reverse cholesterol transport|
|high-density lipoprotein particle remodeling|
|regulation of lipoprotein particle clearance|
|positive regulation of fatty acid biosynthetic process|
|positive regulation of triglyceride metabolic process|
|very-low-density lipoprotein particle|
|regulation of lipoprotein lipase activity|
|negative regulation of receptor-mediated endocytosis|
|cholesterol efflux|
|positive regulation of lipid catabolic process|
|negative regulation of lipid transport|
|plasma lipoprotein particle assembly|
|protein-lipid complex remodeling|
|plasma lipoprotein particle remodeling|
|protein-containing complex remodeling|
|protein-lipid complex assembly|
|positive regulation of fatty acid metabolic process|
|acylglycerol homeostasis|
|regulation of triglyceride metabolic process|
|triglyceride homeostasis|
|plasma lipoprotein particle clearance|
|negative regulation of lipid localization|
|negative regulation of endocytosis|
|plasma lipoprotein particle organization|
|regulation of fatty acid biosynthetic process|
|regulation of cholesterol transport|
|regulation of sterol transport|
|positive regulation of phospholipid metabolic process|
|protein-lipid complex subunit organization|
|cholesterol transport|
|regulation of lipid catabolic process|
|positive regulation of phospholipase activity|
|sterol transport|
|regulation of phospholipase activity|
|positive regulation of lipase activity|
|regulation of plasma lipoprotein particle levels|
|positive regulation of lipid biosynthetic process|
|cholesterol homeostasis|
|sterol homeostasis|
|negative regulation of lipid metabolic process|
|regulation of phospholipid metabolic process|
|regulation of fatty acid metabolic process|
|phospholipid transport|
|regulation of lipase activity|
|regulation of receptor-mediated endocytosis|
|retinoid metabolic process|
|regulation of lipid transport|
|diterpenoid metabolic process|
|terpenoid metabolic process|
|organophosphate ester transport|
|lipid homeostasis|
|organic hydroxy compound transport|
|isoprenoid metabolic process|
|regulation of lipid localization|
|positive regulation of small molecule metabolic process|
|positive regulation of lipid metabolic process|
|lipid binding|
|regulation of cellular ketone metabolic process|
|regulation of lipid biosynthetic process|
|regulation of endocytosis|
|early endosome|
|lipid transport|
|lipid catabolic process|
|lipid localization|
|positive regulation of cellular catabolic process|
|extracellular structure organization|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|organic anion transport|
|negative regulation of transport|
|regulation of vesicle-mediated transport|
|anion transport|
|negative regulation of cellular component organization|
|positive regulation of hydrolase activity|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|protein homodimerization activity|
|cellular lipid metabolic process|
|regulation of catabolic process|
|response to drug|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|lipid metabolic process|
|regulation of hydrolase activity|
|ion transport|
|positive regulation of catalytic activity|
|protein transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|extracellular space|
|establishment of protein localization|
|homeostatic process|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13828
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.44 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APOC2 Expression in NALM6 Cells: -0.44'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>