======= APOL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APOL1
  * **<color #00a2e8>Official Name</color>**: apolipoprotein L1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8542|8542]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14791|O14791]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APOL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APOL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603743|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ApoL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intrinsic component of membrane|
|very-low-density lipoprotein particle|
|high-density lipoprotein particle|
|cytolysis|
|killing of cells of other organism|
|disruption of cells of other organism|
|chloride channel activity|
|chloride transmembrane transport|
|cell killing|
|chloride transport|
|inorganic anion transmembrane transport|
|cholesterol metabolic process|
|lipoprotein metabolic process|
|secondary alcohol metabolic process|
|sterol metabolic process|
|blood microparticle|
|lipid binding|
|modification of morphology or physiology of other organism|
|inorganic anion transport|
|receptor-mediated endocytosis|
|steroid metabolic process|
|anion transmembrane transport|
|lipid transport|
|endoplasmic reticulum lumen|
|alcohol metabolic process|
|lipid localization|
|post-translational protein modification|
|organic hydroxy compound metabolic process|
|endocytosis|
|anion transport|
|inorganic ion transmembrane transport|
|import into cell|
|innate immune response|
|interspecies interaction between organisms|
|ion transmembrane transport|
|defense response to other organism|
|lipid metabolic process|
|transmembrane transport|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|ion transport|
|extracellular space|
|small molecule metabolic process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp134|MS023 2μM R03 exp134]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4705
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APOL1 Expression in NALM6 Cells: 4.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>