======= APPL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APPL1
  * **<color #00a2e8>Official Name</color>**: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26060|26060]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UKG1|Q9UKG1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APPL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APPL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604299|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor signaling pathway. {ECO:0000269|PubMed:10490823, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:26073777}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PID|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|
|positive regulation of macropinocytosis|
|regulation of macropinocytosis|
|intracellular vesicle|
|positive regulation of melanin biosynthetic process|
|positive regulation of pinocytosis|
|positive regulation of secondary metabolite biosynthetic process|
|adiponectin-activated signaling pathway|
|regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|
|macropinosome|
|regulation of melanin biosynthetic process|
|protein kinase B binding|
|regulation of pinocytosis|
|early phagosome|
|regulation of secondary metabolite biosynthetic process|
|regulation of Fc receptor mediated stimulatory signaling pathway|
|regulation of secondary metabolic process|
|cellular response to hepatocyte growth factor stimulus|
|positive regulation of cytokine production involved in inflammatory response|
|response to hepatocyte growth factor|
|negative regulation of phagocytosis|
|regulation of toll-like receptor 4 signaling pathway|
|vesicle membrane|
|regulation of fibroblast migration|
|signal transduction in absence of ligand|
|extrinsic apoptotic signaling pathway in absence of ligand|
|positive regulation of glucose import|
|beta-tubulin binding|
|regulation of cytokine production involved in inflammatory response|
|positive regulation of glucose transmembrane transport|
|regulation of glucose import|
|phosphatidylserine binding|
|regulation of toll-like receptor signaling pathway|
|regulation of glucose transmembrane transport|
|phosphatidylinositol binding|
|insulin receptor signaling pathway|
|ruffle|
|regulation of protein localization to plasma membrane|
|protein import into nucleus|
|regulation of phagocytosis|
|extrinsic apoptotic signaling pathway|
|positive regulation of endocytosis|
|transforming growth factor beta receptor signaling pathway|
|import into nucleus|
|regulation of protein localization to cell periphery|
|negative regulation of immune effector process|
|positive regulation of inflammatory response|
|protein import|
|early endosome membrane|
|cellular response to transforming growth factor beta stimulus|
|protein localization to nucleus|
|response to transforming growth factor beta|
|cellular response to insulin stimulus|
|hormone-mediated signaling pathway|
|regulation of protein localization to membrane|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|positive regulation of transmembrane transport|
|regulation of endocytosis|
|endosome membrane|
|response to insulin|
|cytoplasmic vesicle|
|early endosome|
|nucleocytoplasmic transport|
|nuclear transport|
|protein-containing complex binding|
|cellular response to peptide hormone stimulus|
|endosome|
|apoptotic signaling pathway|
|cellular response to peptide|
|regulation of inflammatory response|
|response to peptide hormone|
|establishment of protein localization to organelle|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of innate immune response|
|regulation of immune effector process|
|response to peptide|
|positive regulation of defense response|
|negative regulation of transport|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of response to biotic stimulus|
|response to growth factor|
|regulation of cellular protein localization|
|regulation of vesicle-mediated transport|
|cell population proliferation|
|regulation of transmembrane transport|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|regulation of cytokine production|
|enzyme linked receptor protein signaling pathway|
|protein localization to organelle|
|regulation of defense response|
|regulation of multi-organism process|
|regulation of cell migration|
|protein homodimerization activity|
|response to hormone|
|regulation of cell motility|
|regulation of cellular localization|
|apoptotic process|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|intracellular protein transport|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|programmed cell death|
|cellular response to oxygen-containing compound|
|identical protein binding|
|response to nitrogen compound|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|regulation of immune response|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|positive regulation of cellular biosynthetic process|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16306
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APPL1 Expression in NALM6 Cells: 6.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>