======= AQP11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AQP11
  * **<color #00a2e8>Official Name</color>**: aquaporin 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=282679|282679]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NBQ7|Q8NBQ7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AQP11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AQP11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609914|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MIP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endosomal lumen acidification|
|proximal tubule development|
|glycerol transport|
|urea transport|
|polyol transport|
|one-carbon compound transport|
|channel activity|
|water transport|
|fluid transport|
|intracellular pH reduction|
|pH reduction|
|carbohydrate transport|
|endosome organization|
|nephron tubule development|
|renal tubule development|
|regulation of intracellular pH|
|regulation of cellular pH|
|nephron epithelium development|
|regulation of pH|
|cellular monovalent inorganic cation homeostasis|
|nephron development|
|kidney epithelium development|
|organic hydroxy compound transport|
|monovalent inorganic cation homeostasis|
|cytoplasmic vesicle membrane|
|kidney development|
|renal system development|
|vesicle organization|
|urogenital system development|
|protein homooligomerization|
|endomembrane system organization|
|dendrite|
|protein complex oligomerization|
|cell surface|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|molecular function|
|ion homeostasis|
|tube development|
|cellular homeostasis|
|endoplasmic reticulum|
|chemical homeostasis|
|epithelium development|
|transmembrane transport|
|ion transport|
|protein-containing complex assembly|
|amide transport|
|homeostatic process|
|tissue development|
|nitrogen compound transport|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.98|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.71|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7528
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.94 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AQP11 Expression in NALM6 Cells: 1.94'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>