======= AQP9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AQP9
  * **<color #00a2e8>Official Name</color>**: aquaporin 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=366|366]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43315|O43315]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AQP9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AQP9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602914|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The aquaporins are a family of water-selective membrane channels. This gene encodes a member of a subset of aquaporins called the aquaglyceroporins. This protein allows passage of a broad range of noncharged solutes and also stimulates urea transport and osmotic water permeability. This protein may also facilitate the uptake of glycerol in hepatic tissue . The encoded protein may also play a role in specialized leukocyte functions such as immunological response and bactericidal activity. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol. {ECO:0000269|PubMed:10564231}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MIP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|carboxylic acid transmembrane transporter activity|
|purine nucleobase transmembrane transporter activity|
|pyrimidine nucleobase transmembrane transporter activity|
|amine transmembrane transporter activity|
|polyol transmembrane transporter activity|
|purine nucleobase transmembrane transport|
|urea channel activity|
|pyrimidine nucleobase transport|
|canalicular bile acid transport|
|glycerol channel activity|
|water transmembrane transporter activity|
|glycerol transport|
|amine transport|
|purine nucleobase transport|
|urea transmembrane transporter activity|
|urea transmembrane transport|
|purine-containing compound transmembrane transport|
|nucleobase transport|
|urea transport|
|pyrimidine-containing compound transmembrane transport|
|response to mercury ion|
|polyol transport|
|water channel activity|
|one-carbon compound transport|
|water transport|
|fluid transport|
|bile acid and bile salt transport|
|excretion|
|cellular response to cAMP|
|water homeostasis|
|carbohydrate transport|
|response to osmotic stress|
|acid secretion|
|response to cAMP|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|response to organophosphorus|
|monocarboxylic acid transport|
|organic hydroxy compound transport|
|response to purine-containing compound|
|basolateral plasma membrane|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|lipid localization|
|response to metal ion|
|organic anion transport|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|anion transport|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|intracellular membrane-bounded organelle|
|response to organic cyclic compound|
|ion transmembrane transport|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|secretion|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|amide transport|
|homeostatic process|
|nitrogen compound transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16645
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AQP9 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>