======= AQR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AQR
  * **<color #00a2e8>Official Name</color>**: aquarius intron-binding spliceosomal factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9716|9716]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60306|O60306]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AQR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AQR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610548|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. {ECO:0000269|PubMed:16949364}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U2-type catalytic step 2 spliceosome|
|RNA helicase activity|
|transcription-coupled nucleotide-excision repair|
|catalytic step 2 spliceosome|
|spliceosomal complex|
|nucleotide-excision repair|
|mRNA binding|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|DNA repair|
|mRNA metabolic process|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|RNA processing|
|RNA binding|
|ATP binding|
|RNA metabolic process|
|cellular response to stress|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-2.38|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.78|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.76|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.71|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.73|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|1.74|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|1.76|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.76|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|1.77|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.84|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|1.97|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.03|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|2.09|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|2.23|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|2.3|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|2.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.583|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.553|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.551|
|[[:human genes:p:prim1|PRIM1]]|0.545|
|[[:human genes:t:tceb3c|TCEB3C]]|0.544|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.531|
|[[:human genes:c:chd4|CHD4]]|0.531|
|[[:human genes:p:polr2j3|POLR2J3]]|0.525|
|[[:human genes:c:ccna2|CCNA2]]|0.523|
|[[:human genes:c:c14orf93|C14orf93]]|0.523|
|[[:human genes:p:psmb2|PSMB2]]|0.521|
|[[:human genes:v:vasn|VASN]]|0.519|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.518|
|[[:human genes:t:tyms|TYMS]]|0.516|
|[[:human genes:c:cactin|CACTIN]]|0.514|
|[[:human genes:t:tfip11|TFIP11]]|0.508|
|[[:human genes:p:psma6|PSMA6]]|0.508|
|[[:human genes:s:supt5h|SUPT5H]]|0.508|
|[[:human genes:t:tuba8|TUBA8]]|0.507|
|[[:human genes:m:mt1e|MT1E]]|0.506|
|[[:human genes:t:ticrr|TICRR]]|0.504|
|[[:human genes:s:snrpa1|SNRPA1]]|0.503|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.503|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.502|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.501|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.501|
|[[:human genes:s:syt9|SYT9]]|0.5|
|[[:human genes:i:itga2b|ITGA2B]]|0.499|
|[[:human genes:d:dtl|DTL]]|0.497|
|[[:human genes:m:med12|MED12]]|0.496|
|[[:human genes:p:psmb4|PSMB4]]|0.496|
|[[:human genes:c:cmya5|CMYA5]]|0.493|
|[[:human genes:v:vps28|VPS28]]|0.493|
|[[:human genes:p:psmd3|PSMD3]]|0.492|
|[[:human genes:s:s1pr4|S1PR4]]|0.488|
|[[:human genes:d:disp2|DISP2]]|0.488|
|[[:human genes:r:rrp7a|RRP7A]]|0.487|
|[[:human genes:s:slc4a1|SLC4A1]]|0.487|
|[[:human genes:r:rpl35|RPL35]]|0.485|
|[[:human genes:c:copg1|COPG1]]|0.484|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.484|
|[[:human genes:r:rad51|RAD51]]|0.482|
|[[:human genes:u:utp3|UTP3]]|0.481|
|[[:human genes:a:aatf|AATF]]|0.481|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.48|
|[[:human genes:c:chaf1a|CHAF1A]]|0.48|
|[[:human genes:a:art5|ART5]]|0.479|
|[[:human genes:n:npipb5|NPIPB5]]|0.478|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.477|
|[[:human genes:p:pan2|PAN2]]|0.474|
|[[:human genes:g:gar1|GAR1]]|0.474|
|[[:human genes:a:aamp|AAMP]]|0.473|
|[[:human genes:h:hinfp|HINFP]]|0.473|
|[[:human genes:r:rps12|RPS12]]|0.472|
|[[:human genes:m:myo1h|MYO1H]]|0.47|
|[[:human genes:p:psap|PSAP]]|0.467|
|[[:human genes:f:fam25b|FAM25B]]|0.465|
|[[:human genes:o:orc1|ORC1]]|0.465|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.464|
|[[:human genes:c:cdc73|CDC73]]|0.464|
|[[:human genes:d:ddtl|DDTL]]|0.463|
|[[:human genes:r:rpsa|RPSA]]|0.463|
|[[:human genes:s:sf3a1|SF3A1]]|0.461|
|[[:human genes:m:med29|MED29]]|0.459|
|[[:human genes:n:nol12|NOL12]]|0.459|
|[[:human genes:s:slc38a7|SLC38A7]]|0.459|
|[[:human genes:r:rbbp5|RBBP5]]|0.458|
|[[:human genes:o:ogfr|OGFR]]|0.457|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.457|
|[[:human genes:k:krt78|KRT78]]|0.456|
|[[:human genes:l:lrr1|LRR1]]|0.455|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.455|
|[[:human genes:i:igfn1|IGFN1]]|0.454|
|[[:human genes:s:slc6a17|SLC6A17]]|0.454|
|[[:human genes:m:med14|MED14]]|0.454|
|[[:human genes:c:cbwd3|CBWD3]]|0.454|
|[[:human genes:r:rrp15|RRP15]]|0.453|
|[[:human genes:n:nup160|NUP160]]|0.453|
|[[:human genes:p:phf2|PHF2]]|0.453|
|[[:human genes:p:psmc5|PSMC5]]|0.452|
|[[:human genes:p:plk1|PLK1]]|0.452|
|[[:human genes:c:cln6|CLN6]]|0.452|
|[[:human genes:s:supt6h|SUPT6H]]|0.451|
|[[:human genes:t:ttc1|TTC1]]|0.451|
|[[:human genes:r:rps2|RPS2]]|0.45|
|[[:human genes:p:psmc6|PSMC6]]|0.448|
|[[:human genes:c:cdca3|CDCA3]]|0.447|
|[[:human genes:r:rpl6|RPL6]]|0.447|
|[[:human genes:p:polr2l|POLR2L]]|0.446|
|[[:human genes:c:cbwd5|CBWD5]]|0.446|
|[[:human genes:n:nup153|NUP153]]|0.446|
|[[:human genes:d:dhx38|DHX38]]|0.445|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.445|
|[[:human genes:i:iscu|ISCU]]|0.445|
|[[:human genes:c:cnpy3|CNPY3]]|0.444|
|[[:human genes:n:napa|NAPA]]|0.444|
|[[:human genes:h:hap1|HAP1]]|0.443|
|[[:human genes:c:cope|COPE]]|0.443|
|[[:human genes:i:ik|IK]]|0.443|
|[[:human genes:s:ssh2|SSH2]]|0.443|
|[[:human genes:p:psmd11|PSMD11]]|0.442|
|[[:human genes:n:nupl1|NUPL1]]|0.441|
|[[:human genes:p:pan3|PAN3]]|0.441|
|[[:human genes:r:ranbp2|RANBP2]]|0.441|
|[[:human genes:c:copa|COPA]]|0.44|
|[[:human genes:e:exosc9|EXOSC9]]|0.438|
|[[:human genes:c:cdc6|CDC6]]|0.437|
|[[:human genes:d:dido1|DIDO1]]|0.437|
|[[:human genes:p:polr2f|POLR2F]]|0.437|
|[[:human genes:c:copb1|COPB1]]|0.436|
|[[:human genes:b:bysl|BYSL]]|0.435|
|[[:human genes:m:med17|MED17]]|0.435|
|[[:human genes:t:ttc31|TTC31]]|0.434|
|[[:human genes:o:orc6|ORC6]]|0.433|
|[[:human genes:e:elmod3|ELMOD3]]|0.432|
|[[:human genes:p:pcf11|PCF11]]|0.432|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.432|
|[[:human genes:t:twistnb|TWISTNB]]|0.432|
|[[:human genes:x:xab2|XAB2]]|0.431|
|[[:human genes:u:ubap1|UBAP1]]|0.43|
|[[:human genes:n:nol10|NOL10]]|0.43|
|[[:human genes:c:chmp2a|CHMP2A]]|0.429|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.428|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.428|
|[[:human genes:r:rps5|RPS5]]|0.427|
|[[:human genes:f:fcn2|FCN2]]|0.427|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.427|
|[[:human genes:z:zfand5|ZFAND5]]|0.426|
|[[:human genes:g:gid4|GID4]]|0.426|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.426|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.426|
|[[:human genes:c:cep192|CEP192]]|0.425|
|[[:human genes:p:pole|POLE]]|0.423|
|[[:human genes:a:ankle1|ANKLE1]]|0.423|
|[[:human genes:c:ccdc94|CCDC94]]|0.423|
|[[:human genes:c:cbwd6|CBWD6]]|0.421|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.421|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.42|
|[[:human genes:s:sfpq|SFPQ]]|0.42|
|[[:human genes:z:znf830|ZNF830]]|0.42|
|[[:human genes:c:cdh24|CDH24]]|0.42|
|[[:human genes:p:psmc2|PSMC2]]|0.419|
|[[:human genes:a:atp1a3|ATP1A3]]|0.418|
|[[:human genes:d:ddx56|DDX56]]|0.418|
|[[:human genes:r:rad21|RAD21]]|0.418|
|[[:human genes:s:scaf1|SCAF1]]|0.417|
|[[:human genes:t:trim52|TRIM52]]|0.416|
|[[:human genes:p:paf1|PAF1]]|0.415|
|[[:human genes:w:wdr87|WDR87]]|0.415|
|[[:human genes:p:psmd7|PSMD7]]|0.415|
|[[:human genes:p:pwp2|PWP2]]|0.415|
|[[:human genes:c:cdc45|CDC45]]|0.415|
|[[:human genes:t:traip|TRAIP]]|0.415|
|[[:human genes:f:fancm|FANCM]]|0.414|
|[[:human genes:g:gprin2|GPRIN2]]|0.414|
|[[:human genes:r:rpl30|RPL30]]|0.413|
|[[:human genes:n:nup85|NUP85]]|0.413|
|[[:human genes:p:parp3|PARP3]]|0.413|
|[[:human genes:r:rps7|RPS7]]|0.412|
|[[:human genes:d:ddx47|DDX47]]|0.412|
|[[:human genes:n:nup54|NUP54]]|0.412|
|[[:human genes:a:akirin2|AKIRIN2]]|0.411|
|[[:human genes:p:psmd2|PSMD2]]|0.411|
|[[:human genes:m:myb|MYB]]|0.41|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.41|
|[[:human genes:a:aaas|AAAS]]|0.41|
|[[:human genes:r:rplp1|RPLP1]]|0.409|
|[[:human genes:e:egr2|EGR2]]|0.409|
|[[:human genes:f:fbxw9|FBXW9]]|0.409|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.409|
|[[:human genes:r:rnf113a|RNF113A]]|0.409|
|[[:human genes:s:sec13|SEC13]]|0.408|
|[[:human genes:i:itgax|ITGAX]]|0.408|
|[[:human genes:p:palb2|PALB2]]|0.408|
|[[:human genes:z:znf541|ZNF541]]|0.408|
|[[:human genes:a:apc2|APC2]]|0.408|
|[[:human genes:n:nop16|NOP16]]|0.408|
|[[:human genes:n:nuf2|NUF2]]|0.408|
|[[:human genes:p:polr2a|POLR2A]]|0.407|
|[[:human genes:s:snip1|SNIP1]]|0.407|
|[[:human genes:s:sf3a2|SF3A2]]|0.406|
|[[:human genes:p:pold1|POLD1]]|0.405|
|[[:human genes:e:exosc3|EXOSC3]]|0.405|
|[[:human genes:p:pola1|POLA1]]|0.405|
|[[:human genes:r:rrn3|RRN3]]|0.405|
|[[:human genes:r:rpl14|RPL14]]|0.404|
|[[:human genes:e:exd1|EXD1]]|0.404|
|[[:human genes:s:scgb1c1|SCGB1C1]]|0.404|
|[[:human genes:g:golga6a|GOLGA6A]]|0.404|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.404|
|[[:human genes:h:hivep3|HIVEP3]]|0.403|
|[[:human genes:p:pola2|POLA2]]|0.402|
|[[:human genes:r:rpl37a|RPL37A]]|0.402|
|[[:human genes:a:ahctf1|AHCTF1]]|0.401|
|[[:human genes:n:narfl|NARFL]]|0.4|
|[[:human genes:r:rrp9|RRP9]]|0.4|
|[[:human genes:a:acsf2|ACSF2]]|0.4|
|[[:human genes:c:ctage4|CTAGE4]]|0.4|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 424/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|8/28|
|blood|23/28|
|bone|13/26|
|breast|21/33|
|central nervous system|28/56|
|cervix|1/4|
|colorectal|13/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|8/16|
|kidney|12/21|
|liver|9/20|
|lung|37/75|
|lymphocyte|12/16|
|ovary|18/26|
|pancreas|15/24|
|peripheral nervous system|12/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|11/24|
|soft tissue|7/9|
|thyroid|1/2|
|upper aerodigestive|13/22|
|urinary tract|5/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 349
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AQR Expression in NALM6 Cells: 7.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>