======= ARCN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARCN1
  * **<color #00a2e8>Official Name</color>**: archain 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=372|372]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48444|P48444]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARCN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARCN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600820|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene maps in a region, which include the mixed lineage leukemia and Friend leukemia virus integration 1 genes, where multiple disease-associated chromosome translocations occur. It is an intracellular protein. Archain sequences are well conserved among eukaryotes and this protein may play a fundamental role in eukaryotic cell biology. It has similarities to heat shock proteins and clathrin-associated proteins, and may be involved in vesicle structure or trafficking. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Adap comp sub|
|Clat adaptor s|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cerebellar Purkinje cell layer maturation|
|cerebellum maturation|
|cerebellar cortex maturation|
|hindbrain maturation|
|central nervous system maturation|
|COPI-coated vesicle|
|Golgi localization|
|COPI vesicle coat|
|cerebellar Purkinje cell layer development|
|cerebellar cortex development|
|adult locomotory behavior|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|pigmentation|
|transport vesicle|
|cerebellum development|
|metencephalon development|
|anatomical structure maturation|
|adult behavior|
|hindbrain development|
|locomotory behavior|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|developmental maturation|
|Golgi vesicle transport|
|behavior|
|organelle localization|
|Golgi membrane|
|brain development|
|head development|
|endoplasmic reticulum membrane|
|central nervous system development|
|intracellular protein transport|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-2.43|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.39|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.27|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.17|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-2.08|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-2.07|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2.06|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.05|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.94|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.93|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-1.9|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.88|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.87|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.85|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.78|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.76|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.75|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.74|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.71|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.72|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.76|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.76|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.81|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.94|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.98|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|2.01|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|2.02|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:copb1|COPB1]]|0.555|
|[[:human genes:c:copg1|COPG1]]|0.536|
|[[:human genes:p:psmb4|PSMB4]]|0.526|
|[[:human genes:v:vps54|VPS54]]|0.505|
|[[:human genes:a:ankle2|ANKLE2]]|0.502|
|[[:human genes:c:chd4|CHD4]]|0.498|
|[[:human genes:c:copb2|COPB2]]|0.497|
|[[:human genes:s:supt5h|SUPT5H]]|0.497|
|[[:human genes:p:pola1|POLA1]]|0.494|
|[[:human genes:c:cope|COPE]]|0.491|
|[[:human genes:v:vasn|VASN]]|0.49|
|[[:human genes:p:psmc2|PSMC2]]|0.49|
|[[:human genes:z:znf830|ZNF830]]|0.488|
|[[:human genes:r:rrp15|RRP15]]|0.487|
|[[:human genes:n:nup160|NUP160]]|0.487|
|[[:human genes:o:orc6|ORC6]]|0.483|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.483|
|[[:human genes:r:rbm39|RBM39]]|0.482|
|[[:human genes:o:osbp|OSBP]]|0.481|
|[[:human genes:c:copa|COPA]]|0.481|
|[[:human genes:a:aamp|AAMP]]|0.479|
|[[:human genes:s:supt6h|SUPT6H]]|0.478|
|[[:human genes:t:ticrr|TICRR]]|0.476|
|[[:human genes:s:slc6a17|SLC6A17]]|0.474|
|[[:human genes:p:pan3|PAN3]]|0.473|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.469|
|[[:human genes:n:nol10|NOL10]]|0.469|
|[[:human genes:c:copz1|COPZ1]]|0.469|
|[[:human genes:p:paf1|PAF1]]|0.469|
|[[:human genes:u:upf1|UPF1]]|0.468|
|[[:human genes:p:psmd3|PSMD3]]|0.464|
|[[:human genes:s:smg1|SMG1]]|0.462|
|[[:human genes:p:prkcz|PRKCZ]]|0.46|
|[[:human genes:n:nupl1|NUPL1]]|0.459|
|[[:human genes:t:tfip11|TFIP11]]|0.459|
|[[:human genes:m:mylk3|MYLK3]]|0.458|
|[[:human genes:p:psmd1|PSMD1]]|0.457|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.457|
|[[:human genes:c:chaf1a|CHAF1A]]|0.455|
|[[:human genes:c:cbwd3|CBWD3]]|0.454|
|[[:human genes:s:sap30bp|SAP30BP]]|0.454|
|[[:human genes:t:tceb3c|TCEB3C]]|0.453|
|[[:human genes:z:zfand5|ZFAND5]]|0.45|
|[[:human genes:o:orc1|ORC1]]|0.447|
|[[:human genes:p:prim1|PRIM1]]|0.445|
|[[:human genes:e:exosc6|EXOSC6]]|0.442|
|[[:human genes:c:cdc73|CDC73]]|0.441|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.441|
|[[:human genes:p:plk4|PLK4]]|0.441|
|[[:human genes:p:psmd7|PSMD7]]|0.44|
|[[:human genes:c:cdc45|CDC45]]|0.437|
|[[:human genes:s:sec13|SEC13]]|0.437|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.436|
|[[:human genes:s:slc4a1|SLC4A1]]|0.436|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.436|
|[[:human genes:m:myo1h|MYO1H]]|0.436|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.435|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.435|
|[[:human genes:s:stil|STIL]]|0.434|
|[[:human genes:p:pan2|PAN2]]|0.434|
|[[:human genes:l:lrr1|LRR1]]|0.434|
|[[:human genes:n:napa|NAPA]]|0.433|
|[[:human genes:m:mt1e|MT1E]]|0.432|
|[[:human genes:e:eif4a3|EIF4A3]]|0.432|
|[[:human genes:d:ddtl|DDTL]]|0.431|
|[[:human genes:i:iscu|ISCU]]|0.431|
|[[:human genes:r:rpl34|RPL34]]|0.43|
|[[:human genes:s:smg7|SMG7]]|0.43|
|[[:human genes:z:znf541|ZNF541]]|0.429|
|[[:human genes:r:rps19|RPS19]]|0.429|
|[[:human genes:o:ogfr|OGFR]]|0.429|
|[[:human genes:p:polr1a|POLR1A]]|0.428|
|[[:human genes:i:igfn1|IGFN1]]|0.428|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.427|
|[[:human genes:c:ccna2|CCNA2]]|0.427|
|[[:human genes:c:cbwd5|CBWD5]]|0.427|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.427|
|[[:human genes:a:akirin2|AKIRIN2]]|0.427|
|[[:human genes:e:exosc9|EXOSC9]]|0.427|
|[[:human genes:r:rbm48|RBM48]]|0.427|
|[[:human genes:n:nup205|NUP205]]|0.426|
|[[:human genes:m:myb|MYB]]|0.426|
|[[:human genes:c:cgb2|CGB2]]|0.426|
|[[:human genes:t:tgfbrap1|TGFBRAP1]]|0.425|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.425|
|[[:human genes:p:psmb2|PSMB2]]|0.425|
|[[:human genes:r:rpl35|RPL35]]|0.422|
|[[:human genes:z:znf655|ZNF655]]|0.422|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.422|
|[[:human genes:r:riok2|RIOK2]]|0.422|
|[[:human genes:k:krt78|KRT78]]|0.422|
|[[:human genes:h:hap1|HAP1]]|0.421|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.421|
|[[:human genes:c:cog4|COG4]]|0.421|
|[[:human genes:c:ccdc94|CCDC94]]|0.421|
|[[:human genes:r:rpl35a|RPL35A]]|0.42|
|[[:human genes:r:rpl30|RPL30]]|0.419|
|[[:human genes:o:or10g3|OR10G3]]|0.419|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.417|
|[[:human genes:b:bysl|BYSL]]|0.416|
|[[:human genes:u:ubap1|UBAP1]]|0.416|
|[[:human genes:p:psmb3|PSMB3]]|0.416|
|[[:human genes:v:vps52|VPS52]]|0.415|
|[[:human genes:d:dock6|DOCK6]]|0.414|
|[[:human genes:c:cbwd6|CBWD6]]|0.414|
|[[:human genes:r:rps2|RPS2]]|0.413|
|[[:human genes:g:gid4|GID4]]|0.412|
|[[:human genes:l:lad1|LAD1]]|0.412|
|[[:human genes:m:myo18a|MYO18A]]|0.411|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.411|
|[[:human genes:n:narfl|NARFL]]|0.411|
|[[:human genes:r:rpl9|RPL9]]|0.41|
|[[:human genes:t:trappc11|TRAPPC11]]|0.41|
|[[:human genes:u:utp3|UTP3]]|0.41|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.41|
|[[:human genes:u:uqcrh|UQCRH]]|0.409|
|[[:human genes:a:acsf2|ACSF2]]|0.409|
|[[:human genes:c:ctr9|CTR9]]|0.409|
|[[:human genes:p:psmb1|PSMB1]]|0.408|
|[[:human genes:b:brd2|BRD2]]|0.408|
|[[:human genes:i:ints5|INTS5]]|0.408|
|[[:human genes:p:psmd14|PSMD14]]|0.408|
|[[:human genes:s:sf3a3|SF3A3]]|0.407|
|[[:human genes:i:ik|IK]]|0.407|
|[[:human genes:k:kctd17|KCTD17]]|0.406|
|[[:human genes:r:rps14|RPS14]]|0.406|
|[[:human genes:s:snrpa1|SNRPA1]]|0.406|
|[[:human genes:s:snrnp70|SNRNP70]]|0.406|
|[[:human genes:c:cactin|CACTIN]]|0.405|
|[[:human genes:w:wdr75|WDR75]]|0.405|
|[[:human genes:f:fam160a1|FAM160A1]]|0.405|
|[[:human genes:g:gar1|GAR1]]|0.404|
|[[:human genes:n:nfatc4|NFATC4]]|0.403|
|[[:human genes:r:rad51|RAD51]]|0.402|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.402|
|[[:human genes:r:rps28|RPS28]]|0.401|
|[[:human genes:c:cdt1|CDT1]]|0.401|
|[[:human genes:n:nbpf10|NBPF10]]|0.401|
|[[:human genes:c:cox8a|COX8A]]|0.4|
|[[:human genes:t:tspy8|TSPY8]]|0.4|
|[[:human genes:p:psma6|PSMA6]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 645/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|22/28|
|bone|21/26|
|breast|32/33|
|central nervous system|49/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|21/21|
|liver|18/20|
|lung|61/75|
|lymphocyte|15/16|
|ovary|25/26|
|pancreas|18/24|
|peripheral nervous system|14/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|9/9|
|thyroid|1/2|
|upper aerodigestive|21/22|
|urinary tract|23/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 752
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.1 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARCN1 Expression in NALM6 Cells: 7.1'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>