======= ARF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARF1
  * **<color #00a2e8>Official Name</color>**: ADP ribosylation factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=375|375]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P84077|P84077]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/103180|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|G-alpha|
|Gtr1 RagA|
|Ras|
|SRPRB|
|Miro|
|Arf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phospholipase D activator activity|
|Golgi to transport vesicle transport|
|mitotic cleavage furrow ingression|
|positive regulation of late endosome to lysosome transport|
|positive regulation of vacuolar transport|
|cleavage furrow ingression|
|lysosomal membrane organization|
|positive regulation of ER to Golgi vesicle-mediated transport|
|regulation of late endosome to lysosome transport|
|regulation of vacuolar transport|
|COPI-coated vesicle|
|synaptic vesicle budding|
|very-low-density lipoprotein particle assembly|
|postsynaptic actin cytoskeleton organization|
|cellular copper ion homeostasis|
|postsynaptic cytoskeleton organization|
|regulation of Arp2/3 complex-mediated actin nucleation|
|regulation of ER to Golgi vesicle-mediated transport|
|copper ion homeostasis|
|long-term synaptic depression|
|positive regulation of calcium ion-dependent exocytosis|
|positive regulation of sodium ion transmembrane transport|
|mitotic cytokinetic process|
|plasma lipoprotein particle assembly|
|regulation of actin nucleation|
|regulation of defense response to virus by virus|
|protein-lipid complex assembly|
|dendritic spine organization|
|cellular response to virus|
|positive regulation of sodium ion transport|
|synaptic vesicle transport|
|cytokinetic process|
|neuron projection organization|
|synaptic vesicle localization|
|cell leading edge|
|positive regulation of dendritic spine development|
|regulation of calcium ion-dependent exocytosis|
|plasma lipoprotein particle organization|
|interleukin-12-mediated signaling pathway|
|cellular response to interleukin-12|
|protein-lipid complex subunit organization|
|response to interleukin-12|
|sarcomere|
|positive regulation of regulated secretory pathway|
|regulation of receptor internalization|
|peroxisomal membrane|
|lytic vacuole organization|
|lysosome organization|
|Golgi to plasma membrane transport|
|negative regulation of synaptic transmission|
|regulation of sodium ion transmembrane transport|
|mitotic cytokinesis|
|regulation of plasma lipoprotein particle levels|
|positive regulation of dendrite development|
|regulation of dendritic spine development|
|GDP binding|
|regulation of phospholipid metabolic process|
|regulation of sodium ion transport|
|postsynapse organization|
|positive regulation of exocytosis|
|vesicle-mediated transport to the plasma membrane|
|cytoskeleton-dependent cytokinesis|
|vesicle budding from membrane|
|cytokinesis|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|positive regulation of endocytosis|
|antigen processing and presentation of peptide antigen via MHC class II|
|regulation of receptor-mediated endocytosis|
|post-Golgi vesicle-mediated transport|
|cellular transition metal ion homeostasis|
|phosphatidylinositol biosynthetic process|
|late endosome|
|vacuole organization|
|transition metal ion homeostasis|
|plasma membrane invagination|
|positive regulation of cation transmembrane transport|
|membrane invagination|
|regulation of dendrite development|
|positive regulation of ion transmembrane transport|
|regulation of regulated secretory pathway|
|regulation of actin filament polymerization|
|phosphatidylinositol metabolic process|
|trans-Golgi network|
|establishment of vesicle localization|
|antigen processing and presentation of exogenous peptide antigen|
|regulation of actin polymerization or depolymerization|
|antigen processing and presentation of exogenous antigen|
|regulation of actin filament length|
|vesicle localization|
|regulation of synaptic plasticity|
|antigen processing and presentation of peptide antigen|
|postsynaptic membrane|
|positive regulation of transmembrane transport|
|regulation of endocytosis|
|glycerophospholipid biosynthetic process|
|positive regulation of intracellular transport|
|magnesium ion binding|
|antigen processing and presentation|
|glycerolipid biosynthetic process|
|regulation of protein polymerization|
|regulation of exocytosis|
|actin filament organization|
|protein domain specific binding|
|phospholipid biosynthetic process|
|postsynaptic density|
|regulation of actin filament organization|
|synapse organization|
|positive regulation of protein secretion|
|positive regulation of ion transport|
|positive regulation of neuron projection development|
|response to virus|
|positive regulation of peptide secretion|
|vesicle organization|
|glycerophospholipid metabolic process|
|neuron projection|
|GTPase activity|
|regulation of cation transmembrane transport|
|regulation of actin cytoskeleton organization|
|glutamatergic synapse|
|regulation of supramolecular fiber organization|
|regulation of intracellular transport|
|establishment of organelle localization|
|positive regulation of neuron differentiation|
|Golgi vesicle transport|
|phospholipid metabolic process|
|regulation of cellular component size|
|glycerolipid metabolic process|
|positive regulation of cell projection organization|
|regulation of metal ion transport|
|extracellular structure organization|
|regulation of actin filament-based process|
|GTP binding|
|regulation of lipid metabolic process|
|positive regulation of secretion by cell|
|focal adhesion|
|positive regulation of protein transport|
|positive regulation of secretion|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of neurogenesis|
|regulation of ion transmembrane transport|
|protein heterodimerization activity|
|cell division|
|actin cytoskeleton organization|
|regulation of peptide secretion|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|positive regulation of nervous system development|
|organophosphate biosynthetic process|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|actin filament-based process|
|lipid biosynthetic process|
|organelle localization|
|protein-containing complex|
|mitotic cell cycle process|
|Golgi membrane|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of neuron differentiation|
|cytokine-mediated signaling pathway|
|mitotic cell cycle|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|viral process|
|cation homeostasis|
|regulation of protein transport|
|regulation of cell projection organization|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|symbiotic process|
|ion homeostasis|
|regulation of secretion|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|membrane organization|
|organophosphate metabolic process|
|cellular homeostasis|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|cellular lipid metabolic process|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|Golgi apparatus|
|positive regulation of transport|
|intracellular protein transport|
|cell cycle process|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|response to cytokine|
|cytoskeleton organization|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|lipid metabolic process|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|RNA binding|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|homeostatic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-4.82|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-3.7|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-2.62|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.59|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.05|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.97|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.88|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-1.88|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.76|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.76|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.74|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.73|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.72|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|1.76|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.8|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 32/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|1/28|
|bone|1/26|
|breast|1/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|0/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16308
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARF1 Expression in NALM6 Cells: 7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>