======= ARF4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARF4
  * **<color #00a2e8>Official Name</color>**: ADP ribosylation factor 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=378|378]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P18085|P18085]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARF4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARF4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601177|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Miro|
|Arf|
|SRPRB|
|Ras|
|G-alpha|
|Gtr1 RagA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|activation of phospholipase D activity|
|apical protein localization|
|ARF guanyl-nucleotide exchange factor activity|
|dendritic spine development|
|protein ADP-ribosylation|
|epidermal growth factor receptor binding|
|establishment or maintenance of epithelial cell apical/basal polarity|
|protein localization to cilium|
|establishment or maintenance of bipolar cell polarity|
|establishment or maintenance of apical/basal cell polarity|
|response to axon injury|
|epidermal growth factor receptor signaling pathway|
|positive regulation of phospholipase activity|
|Golgi to plasma membrane transport|
|ERBB signaling pathway|
|regulation of phospholipase activity|
|positive regulation of lipase activity|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|vesicle-mediated transport to the plasma membrane|
|ruffle membrane|
|regulation of postsynapse organization|
|regulation of lipase activity|
|post-Golgi vesicle-mediated transport|
|dendrite development|
|learning|
|dendritic spine|
|regulation of reactive oxygen species metabolic process|
|establishment or maintenance of cell polarity|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|learning or memory|
|cognition|
|GTPase activity|
|glutamatergic synapse|
|Golgi vesicle transport|
|GTP binding|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|behavior|
|response to wounding|
|neuron projection development|
|enzyme linked receptor protein signaling pathway|
|protein localization to organelle|
|brain development|
|positive regulation of hydrolase activity|
|head development|
|neuron development|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|cell migration|
|central nervous system development|
|Golgi apparatus|
|intracellular protein transport|
|negative regulation of cell death|
|neuron differentiation|
|cell motility|
|localization of cell|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of transcription by RNA polymerase II|
|regulation of hydrolase activity|
|locomotion|
|nervous system process|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of cell death|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-2.37|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.09|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.73|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|1.78|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.93|
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.96|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|5.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 151/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|7/28|
|bone|5/26|
|breast|6/33|
|central nervous system|10/56|
|cervix|0/4|
|colorectal|5/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|9/21|
|liver|8/20|
|lung|14/75|
|lymphocyte|1/16|
|ovary|5/26|
|pancreas|4/24|
|peripheral nervous system|0/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|6/24|
|soft tissue|1/9|
|thyroid|1/2|
|upper aerodigestive|4/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7314
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARF4 Expression in NALM6 Cells: 5.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>