======= ARHGAP6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARHGAP6
  * **<color #00a2e8>Official Name</color>**: Rho GTPase activating protein 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=395|395]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43182|O43182]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARHGAP6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARHGAP6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300118|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RhoGAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phospholipase activator activity|
|phospholipase binding|
|negative regulation of focal adhesion assembly|
|negative regulation of adherens junction organization|
|negative regulation of stress fiber assembly|
|negative regulation of cell junction assembly|
|negative regulation of actin filament bundle assembly|
|cell-substrate adherens junction assembly|
|focal adhesion assembly|
|actin filament polymerization|
|activation of phospholipase C activity|
|adherens junction assembly|
|negative regulation of cell-matrix adhesion|
|cell-substrate junction assembly|
|positive regulation of phospholipase C activity|
|regulation of phospholipase C activity|
|actin polymerization or depolymerization|
|SH3/SH2 adaptor activity|
|positive regulation of phospholipase activity|
|regulation of focal adhesion assembly|
|regulation of cell-substrate junction assembly|
|negative regulation of cell-substrate adhesion|
|regulation of adherens junction organization|
|positive regulation of lipase activity|
|regulation of phospholipase activity|
|Rho protein signal transduction|
|regulation of stress fiber assembly|
|actin filament|
|adherens junction organization|
|protein polymerization|
|regulation of cell junction assembly|
|regulation of actomyosin structure organization|
|regulation of actin filament bundle assembly|
|regulation of lipase activity|
|regulation of cell-matrix adhesion|
|cell-matrix adhesion|
|SH3 domain binding|
|negative regulation of supramolecular fiber organization|
|negative regulation of cytoskeleton organization|
|cell junction assembly|
|cell-substrate adhesion|
|regulation of cell-substrate adhesion|
|cell junction organization|
|actin cytoskeleton|
|actin filament organization|
|Ras protein signal transduction|
|regulation of actin filament organization|
|negative regulation of cell adhesion|
|GTPase activator activity|
|small GTPase mediated signal transduction|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|regulation of actin filament-based process|
|positive regulation of GTPase activity|
|supramolecular fiber organization|
|regulation of GTPase activity|
|actin cytoskeleton organization|
|regulation of cytoskeleton organization|
|actin filament-based process|
|regulation of cell adhesion|
|negative regulation of cellular component organization|
|positive regulation of hydrolase activity|
|cellular protein-containing complex assembly|
|cell adhesion|
|biological adhesion|
|regulation of cellular component biogenesis|
|cytoskeleton organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|positive regulation of catalytic activity|
|protein-containing complex assembly|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.8|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14408
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARHGAP6 Expression in NALM6 Cells: 3.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>