======= ARHGEF26 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARHGEF26
  * **<color #00a2e8>Official Name</color>**: Rho guanine nucleotide exchange factor 26
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26084|26084]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96DR7|Q96DR7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARHGEF26&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARHGEF26|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617552|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 2|
|PH|
|SH3 1|
|RhoGEF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ruffle assembly|
|endothelial cell morphogenesis|
|ruffle organization|
|epithelial cell morphogenesis|
|endothelial cell development|
|Rho guanyl-nucleotide exchange factor activity|
|endothelial cell differentiation|
|ruffle|
|endothelium development|
|regulation of Rho protein signal transduction|
|epithelial cell development|
|regulation of Ras protein signal transduction|
|regulation of small GTPase mediated signal transduction|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|cell morphogenesis involved in differentiation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|epithelial cell differentiation|
|positive regulation of cell death|
|cell morphogenesis|
|cellular component morphogenesis|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|G protein-coupled receptor signaling pathway|
|regulation of apoptotic process|
|regulation of programmed cell death|
|cell development|
|regulation of cell death|
|tissue development|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.81|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.78|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16980
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARHGEF26 Expression in NALM6 Cells: 3.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>