======= ARID2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARID2
  * **<color #00a2e8>Official Name</color>**: AT-rich interaction domain 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=196528|196528]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q68CP9|Q68CP9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARID2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARID2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609539|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the AT-rich interactive domain (ARID)-containing family of DNA-binding proteins. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and chromatin structure modification. This protein functions as a subunit of the polybromo- and BRG1-associated factor or PBAF (SWI/SNF-B) chromatin remodeling complex which facilitates ligand-dependent transcriptional activation by nuclear receptors. Mutations in this gene are associated with hepatocellular carcinomas. A pseudogene of this gene is found on chromosome1. [provided by RefSeq, Dec 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RFX DNA binding|
|ARID|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|coronary artery morphogenesis|
|cardiac muscle cell proliferation|
|striated muscle cell proliferation|
|coronary vasculature morphogenesis|
|muscle cell proliferation|
|nucleosome disassembly|
|chromatin disassembly|
|protein-DNA complex disassembly|
|cardiac muscle tissue growth|
|heart growth|
|coronary vasculature development|
|artery morphogenesis|
|artery development|
|organ growth|
|chromatin assembly or disassembly|
|nucleosome organization|
|cardiac muscle tissue development|
|protein-containing complex disassembly|
|protein-DNA complex subunit organization|
|heart morphogenesis|
|negative regulation of cell migration|
|negative regulation of cell motility|
|striated muscle tissue development|
|muscle tissue development|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|developmental growth|
|growth|
|cellular component disassembly|
|blood vessel morphogenesis|
|embryonic organ development|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|heart development|
|cell population proliferation|
|tube morphogenesis|
|negative regulation of cell population proliferation|
|chromatin organization|
|tube development|
|regulation of cell migration|
|circulatory system development|
|regulation of cell motility|
|animal organ morphogenesis|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|chromosome organization|
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|homeostatic process|
|tissue development|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.74|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.7|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|1.71|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|1.77|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.78|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.91|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.01|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.03|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.09|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|2.1|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.35|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.36|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:zfand5|ZFAND5]]|0.408|
|[[:human genes:r:rbm6|RBM6]]|0.404|
|[[:human genes:p:psmd3|PSMD3]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 10/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1079
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARID2 Expression in NALM6 Cells: 6.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>