======= ARID5B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARID5B
  * **<color #00a2e8>Official Name</color>**: AT-rich interaction domain 5B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84159|84159]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14865|Q14865]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARID5B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARID5B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608538|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipogenesis and liver development. This gene also plays a role in cell growth and differentiation of B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ARID|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fat pad development|
|fibroblast migration|
|adrenal gland development|
|face morphogenesis|
|platelet-derived growth factor receptor signaling pathway|
|adipose tissue development|
|head morphogenesis|
|body morphogenesis|
|face development|
|multicellular organism growth|
|muscle organ morphogenesis|
|female gonad development|
|post-embryonic development|
|roof of mouth development|
|development of primary female sexual characteristics|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|fat cell differentiation|
|female sex differentiation|
|endocrine system development|
|liver development|
|hepaticobiliary system development|
|male gonad development|
|development of primary male sexual characteristics|
|male sex differentiation|
|ameboidal-type cell migration|
|gonad development|
|development of primary sexual characteristics|
|transcription regulatory region DNA binding|
|connective tissue development|
|skeletal system morphogenesis|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|positive regulation of DNA-binding transcription factor activity|
|sex differentiation|
|kidney development|
|transcription coactivator activity|
|renal system development|
|muscle organ development|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|urogenital system development|
|developmental growth|
|growth|
|gland development|
|reproductive structure development|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|muscle structure development|
|skeletal system development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|developmental process involved in reproduction|
|enzyme linked receptor protein signaling pathway|
|head development|
|negative regulation of transcription by RNA polymerase II|
|animal organ morphogenesis|
|cell migration|
|cellular response to cytokine stimulus|
|cell motility|
|localization of cell|
|response to cytokine|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of molecular function|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|1.74|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16800
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARID5B Expression in NALM6 Cells: 6.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>