======= ARIH2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARIH2
  * **<color #00a2e8>Official Name</color>**: ariadne RBR E3 ubiquitin protein ligase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10425|10425]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95376|O95376]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARIH2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARIH2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605615|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin- conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex (PubMed:24076655). Mediates 'Lys-6', 'Lys-48'-and 'Lys- 63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006). {ECO:0000250|UniProtKB:Q9Y4X5, ECO:0000269|PubMed:16118314, ECO:0000269|PubMed:17646546, ECO:0000269|PubMed:19340006, ECO:0000269|PubMed:24076655}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IBR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Cul5-RING ubiquitin ligase complex|
|hematopoietic stem cell proliferation|
|positive regulation of protein targeting to mitochondrion|
|ubiquitin conjugating enzyme binding|
|protein K63-linked ubiquitination|
|regulation of protein targeting to mitochondrion|
|stem cell proliferation|
|protein K48-linked ubiquitination|
|positive regulation of establishment of protein localization to mitochondrion|
|regulation of establishment of protein localization to mitochondrion|
|regulation of protein targeting|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|developmental cell growth|
|cell growth|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of proteasomal protein catabolic process|
|ubiquitin ligase complex|
|positive regulation of mitochondrion organization|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|positive regulation of cellular protein catabolic process|
|regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of intracellular protein transport|
|regulation of mitochondrion organization|
|regulation of proteasomal protein catabolic process|
|positive regulation of intracellular transport|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|ubiquitin protein ligase activity|
|regulation of intracellular protein transport|
|ubiquitin-protein transferase activity|
|regulation of cellular protein catabolic process|
|protein polyubiquitination|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|developmental growth|
|growth|
|positive regulation of protein transport|
|positive regulation of catabolic process|
|positive regulation of establishment of protein localization|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of cellular protein localization|
|modification-dependent macromolecule catabolic process|
|cell population proliferation|
|hemopoiesis|
|proteolysis involved in cellular protein catabolic process|
|hematopoietic or lymphoid organ development|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|immune system development|
|protein catabolic process|
|protein ubiquitination|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|protein modification by small protein conjugation|
|regulation of cellular catabolic process|
|zinc ion binding|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|regulation of catabolic process|
|regulation of protein localization|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|positive regulation of cellular component organization|
|proteolysis|
|regulation of organelle organization|
|positive regulation of cellular protein metabolic process|
|cell development|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.91|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.84|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.72|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.75|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.76|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.8|
|[[:results:exp303|39°C R06 exp303]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8758
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARIH2 Expression in NALM6 Cells: 7.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>