======= ARL6IP5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARL6IP5
  * **<color #00a2e8>Official Name</color>**: ADP ribosylation factor like GTPase 6 interacting protein 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10550|10550]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75915|O75915]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARL6IP5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARL6IP5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605709|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. May be involved in membrane traffic. {ECO:0000250|UniProtKB:Q8R5J9, ECO:0000250|UniProtKB:Q9ES40}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PRA1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of L-glutamate import across plasma membrane|
|regulation of L-glutamate import across plasma membrane|
|negative regulation of neurotransmitter uptake|
|regulation of amino acid transmembrane transport|
|regulation of amino acid import across plasma membrane|
|negative regulation of amino acid transport|
|negative regulation of mitochondrial membrane potential|
|negative regulation of membrane potential|
|negative regulation of anion transmembrane transport|
|intrinsic apoptotic signaling pathway in response to oxidative stress|
|L-glutamate transmembrane transport|
|negative regulation of organic acid transport|
|regulation of neurotransmitter uptake|
|cell death in response to oxidative stress|
|negative regulation of neurotransmitter transport|
|negative regulation of amine transport|
|regulation of anion transmembrane transport|
|negative regulation of response to drug|
|negative regulation of anion transport|
|regulation of amino acid transport|
|L-alpha-amino acid transmembrane transport|
|acidic amino acid transport|
|regulation of organic acid transport|
|L-amino acid transport|
|drug transmembrane transport|
|regulation of mitochondrial membrane potential|
|amino acid transmembrane transport|
|dicarboxylic acid transport|
|regulation of amine transport|
|regulation of anion transport|
|negative regulation of ion transmembrane transport|
|regulation of response to drug|
|negative regulation of transmembrane transport|
|amino acid transport|
|carboxylic acid transmembrane transport|
|organic acid transmembrane transport|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of neurotransmitter transport|
|negative regulation of ion transport|
|drug transport|
|intrinsic apoptotic signaling pathway|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|positive regulation of endopeptidase activity|
|neurotransmitter transport|
|positive regulation of peptidase activity|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|cellular response to oxidative stress|
|regulation of cysteine-type endopeptidase activity|
|anion transmembrane transport|
|apoptotic signaling pathway|
|organic acid transport|
|carboxylic acid transport|
|regulation of neurotransmitter levels|
|positive regulation of proteolysis|
|cytoskeleton|
|response to oxidative stress|
|regulation of endopeptidase activity|
|regulation of membrane potential|
|regulation of peptidase activity|
|organic anion transport|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|positive regulation of MAPK cascade|
|regulation of transmembrane transport|
|anion transport|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|regulation of ion transport|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|molecular function|
|positive regulation of hydrolase activity|
|apoptotic process|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|programmed cell death|
|positive regulation of phosphorylation|
|cell death|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|transmembrane transport|
|ion transport|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|regulation of protein modification process|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13825
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARL6IP5 Expression in NALM6 Cells: 5.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>