======= ARL8A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARL8A
  * **<color #00a2e8>Official Name</color>**: ADP ribosylation factor like GTPase 8A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=127829|127829]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96BM9|Q96BM9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARL8A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARL8A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616597|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Gtr1 RagA|
|Arf|
|Miro|
|SRPRB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spindle midzone|
|vacuolar membrane|
|beta-tubulin binding|
|alpha-tubulin binding|
|anterograde axonal transport|
|axonal transport|
|axon cytoplasm|
|azurophil granule membrane|
|ficolin-1-rich granule membrane|
|axo-dendritic transport|
|late endosome membrane|
|transport along microtubule|
|midbody|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|synapse|
|microtubule-based movement|
|chromosome segregation|
|lysosomal membrane|
|GTPase activity|
|GTP binding|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|cell division|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|cell junction|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|microtubule-based process|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|leukocyte activation|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|cell cycle|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.485|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17255
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARL8A Expression in NALM6 Cells: 4.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>