======= ARPC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARPC2
  * **<color #00a2e8>Official Name</color>**: actin related protein 2/3 complex subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10109|10109]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15144|O15144]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARPC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARPC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604224|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|P34-Arc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|muscle cell projection membrane|
|actin polymerization-dependent cell motility|
|Arp2/3 protein complex|
|positive regulation of lamellipodium assembly|
|Arp2/3 complex-mediated actin nucleation|
|positive regulation of lamellipodium organization|
|regulation of lamellipodium assembly|
|actin filament polymerization|
|actin nucleation|
|positive regulation of substrate adhesion-dependent cell spreading|
|regulation of lamellipodium organization|
|actin polymerization or depolymerization|
|regulation of substrate adhesion-dependent cell spreading|
|site of double-strand break|
|protein polymerization|
|ephrin receptor signaling pathway|
|positive regulation of actin filament polymerization|
|positive regulation of plasma membrane bounded cell projection assembly|
|structural constituent of cytoskeleton|
|positive regulation of cell-substrate adhesion|
|positive regulation of protein polymerization|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|positive regulation of cell morphogenesis involved in differentiation|
|regulation of actin filament polymerization|
|lamellipodium|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of supramolecular fiber organization|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|actin filament binding|
|regulation of cell-substrate adhesion|
|actin cytoskeleton|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|actin filament organization|
|Fc receptor signaling pathway|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|endosome|
|regulation of cell morphogenesis involved in differentiation|
|neuron projection|
|phagocytosis|
|regulation of actin cytoskeleton organization|
|glutamatergic synapse|
|regulation of supramolecular fiber organization|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|positive regulation of cell adhesion|
|focal adhesion|
|immune response-activating cell surface receptor signaling pathway|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|immune response-activating signal transduction|
|actin filament-based process|
|immune response-regulating signaling pathway|
|positive regulation of organelle organization|
|activation of immune response|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|cellular protein-containing complex assembly|
|membrane organization|
|positive regulation of immune response|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|immune effector process|
|cytoskeleton organization|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|locomotion|
|positive regulation of developmental process|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of immune system process|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-2.57|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.23|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.98|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.93|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.91|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-1.8|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.78|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.78|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.76|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.74|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:arpc4|ARPC4]]|0.743|
|[[:human genes:a:actr3|ACTR3]]|0.673|
|[[:human genes:c:commd5|COMMD5]]|0.672|
|[[:human genes:a:actr2|ACTR2]]|0.602|
|[[:human genes:c:commd7|COMMD7]]|0.595|
|[[:human genes:c:commd3|COMMD3]]|0.565|
|[[:human genes:c:ccdc22|CCDC22]]|0.562|
|[[:human genes:c:commd2|COMMD2]]|0.518|
|[[:human genes:v:vps29|VPS29]]|0.511|
|[[:human genes:k:kiaa0196|KIAA0196]]|0.503|
|[[:human genes:c:commd10|COMMD10]]|0.492|
|[[:human genes:c:chka|CHKA]]|0.482|
|[[:human genes:c:commd9|COMMD9]]|0.474|
|[[:human genes:f:flvcr1|FLVCR1]]|0.466|
|[[:human genes:c:commd4|COMMD4]]|0.454|
|[[:human genes:c:commd8|COMMD8]]|0.439|
|[[:human genes:c:ccdc53|CCDC53]]|0.439|
|[[:human genes:c:c16orf62|C16orf62]]|0.435|
|[[:human genes:k:kiaa1033|KIAA1033]]|0.433|
|[[:human genes:v:vps35|VPS35]]|0.428|
|[[:human genes:r:rab7a|RAB7A]]|0.423|
|[[:human genes:m:mmd|MMD]]|0.41|
|[[:human genes:l:lzic|LZIC]]|0.406|
|[[:human genes:a:arpc3|ARPC3]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4369
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARPC2 Expression in NALM6 Cells: 7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>