======= ARPC4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARPC4
  * **<color #00a2e8>Official Name</color>**: actin related protein 2/3 complex subunit 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10093|10093]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P59998|P59998]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARPC4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARPC4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604226|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ARPC4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Arp2/3 protein complex|
|Arp2/3 complex-mediated actin nucleation|
|actin filament polymerization|
|actin nucleation|
|actin polymerization or depolymerization|
|site of double-strand break|
|protein binding, bridging|
|protein polymerization|
|ephrin receptor signaling pathway|
|positive regulation of actin filament polymerization|
|cell projection|
|structural constituent of cytoskeleton|
|positive regulation of protein polymerization|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|regulation of actin filament polymerization|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of supramolecular fiber organization|
|actin filament binding|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|actin filament organization|
|Fc receptor signaling pathway|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|phagocytosis|
|regulation of actin cytoskeleton organization|
|enzyme binding|
|regulation of supramolecular fiber organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|immune response-activating cell surface receptor signaling pathway|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|immune response-regulating cell surface receptor signaling pathway|
|actin cytoskeleton organization|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|immune response-activating signal transduction|
|actin filament-based process|
|immune response-regulating signaling pathway|
|positive regulation of organelle organization|
|activation of immune response|
|enzyme linked receptor protein signaling pathway|
|cellular protein-containing complex assembly|
|membrane organization|
|positive regulation of immune response|
|regulation of cellular component biogenesis|
|immune effector process|
|cytoskeleton organization|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|protein-containing complex assembly|
|regulation of immune system process|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.98|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-2.53|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.36|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.36|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-2.26|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.23|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.15|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-2|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-1.88|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.86|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.85|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:arpc2|ARPC2]]|0.743|
|[[:human genes:a:actr2|ACTR2]]|0.724|
|[[:human genes:a:actr3|ACTR3]]|0.678|
|[[:human genes:c:commd5|COMMD5]]|0.646|
|[[:human genes:c:commd3|COMMD3]]|0.588|
|[[:human genes:c:ccdc22|CCDC22]]|0.569|
|[[:human genes:v:vps29|VPS29]]|0.568|
|[[:human genes:c:commd7|COMMD7]]|0.565|
|[[:human genes:c:commd10|COMMD10]]|0.534|
|[[:human genes:c:commd9|COMMD9]]|0.512|
|[[:human genes:c:chka|CHKA]]|0.504|
|[[:human genes:k:kiaa0196|KIAA0196]]|0.5|
|[[:human genes:c:commd2|COMMD2]]|0.482|
|[[:human genes:r:rab7a|RAB7A]]|0.465|
|[[:human genes:c:commd4|COMMD4]]|0.459|
|[[:human genes:a:acsl4|ACSL4]]|0.459|
|[[:human genes:u:usp32|USP32]]|0.453|
|[[:human genes:c:ccdc53|CCDC53]]|0.449|
|[[:human genes:m:mmd|MMD]]|0.448|
|[[:human genes:a:arpc3|ARPC3]]|0.448|
|[[:human genes:k:kiaa1033|KIAA1033]]|0.447|
|[[:human genes:n:nckap1l|NCKAP1L]]|0.443|
|[[:human genes:v:vps45|VPS45]]|0.436|
|[[:human genes:v:vkorc1l1|VKORC1L1]]|0.43|
|[[:human genes:g:gpr107|GPR107]]|0.429|
|[[:human genes:f:flvcr1|FLVCR1]]|0.427|
|[[:human genes:m:mtmr9|MTMR9]]|0.419|
|[[:human genes:p:pcyt2|PCYT2]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 123/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|9/28|
|blood|1/28|
|bone|1/26|
|breast|2/33|
|central nervous system|9/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|7/21|
|liver|9/20|
|lung|9/75|
|lymphocyte|2/16|
|ovary|8/26|
|pancreas|3/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|9/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2076
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARPC4 Expression in NALM6 Cells: 6.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>