======= ASAH2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ASAH2
  * **<color #00a2e8>Official Name</color>**: N-acylsphingosine amidohydrolase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56624|56624]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NR71|Q9NR71]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ASAH2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ASAH2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611202|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract. {ECO:0000269|PubMed:15946935, ECO:0000269|PubMed:16061940}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ceramidase alk|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ceramidase activity|
|N-acylsphingosine amidohydrolase activity|
|sphingosine biosynthetic process|
|sphingoid biosynthetic process|
|sphingosine metabolic process|
|lipid digestion|
|sphingoid metabolic process|
|diol biosynthetic process|
|ceramide catabolic process|
|diol metabolic process|
|long-chain fatty acid biosynthetic process|
|sphingolipid catabolic process|
|membrane lipid catabolic process|
|ceramide biosynthetic process|
|polyol biosynthetic process|
|caveola|
|ceramide metabolic process|
|sphingolipid biosynthetic process|
|polyol metabolic process|
|digestion|
|alcohol biosynthetic process|
|long-chain fatty acid metabolic process|
|fatty acid biosynthetic process|
|membrane lipid biosynthetic process|
|sphingolipid metabolic process|
|organic hydroxy compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|ammonium ion metabolic process|
|cellular lipid catabolic process|
|membrane lipid metabolic process|
|membrane raft|
|negative regulation of apoptotic signaling pathway|
|lipid catabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|alcohol metabolic process|
|fatty acid metabolic process|
|regulation of apoptotic signaling pathway|
|organic hydroxy compound metabolic process|
|amide biosynthetic process|
|monocarboxylic acid metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|Golgi membrane|
|regulation of mitotic cell cycle|
|calcium ion binding|
|cellular amide metabolic process|
|zinc ion binding|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|carboxylic acid metabolic process|
|apoptotic process|
|cellular lipid metabolic process|
|Golgi apparatus|
|negative regulation of cell death|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|organic acid metabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|cell death|
|response to cytokine|
|regulation of cell cycle|
|lipid metabolic process|
|mitochondrion|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|regulation of apoptotic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|regulation of cell death|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.609|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11333
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.07 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ASAH2 Expression in NALM6 Cells: -0.07'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>