======= ASAH2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ASAH2B
  * **<color #00a2e8>Official Name</color>**: N-acylsphingosine amidohydrolase 2B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=653308|653308]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P0C7U1|P0C7U1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ASAH2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ASAH2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610987|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ceramidase alk|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|N-acylsphingosine amidohydrolase activity|
|sphingosine biosynthetic process|
|sphingoid biosynthetic process|
|sphingosine metabolic process|
|sphingoid metabolic process|
|diol biosynthetic process|
|ceramide catabolic process|
|diol metabolic process|
|long-chain fatty acid biosynthetic process|
|sphingolipid catabolic process|
|membrane lipid catabolic process|
|polyol biosynthetic process|
|ceramide metabolic process|
|sphingolipid biosynthetic process|
|polyol metabolic process|
|alcohol biosynthetic process|
|long-chain fatty acid metabolic process|
|fatty acid biosynthetic process|
|membrane lipid biosynthetic process|
|sphingolipid metabolic process|
|monocarboxylic acid biosynthetic process|
|organic hydroxy compound biosynthetic process|
|ammonium ion metabolic process|
|cellular lipid catabolic process|
|membrane lipid metabolic process|
|lipid catabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|alcohol metabolic process|
|fatty acid metabolic process|
|organic hydroxy compound metabolic process|
|monocarboxylic acid metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.74|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.448|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9776
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ASAH2B Expression in NALM6 Cells: 1.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>