======= ASB3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ASB3
  * **<color #00a2e8>Official Name</color>**: ankyrin repeat and SOCS box containing 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51130|51130]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y575|Q9Y575]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ASB3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ASB3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605760|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank 2|
|SOCS box|
|Ank|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|post-translational protein modification|
|protein ubiquitination|
|protein modification by small protein conjugation|
|protein modification by small protein conjugation or removal|
|intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-3.58|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-3.44|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-3.42|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-3.02|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-2.96|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-2.91|
|[[:results:exp16|DABN 2μM R00 exp16]]|-2.86|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.8|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-2.77|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-2.71|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-2.68|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-2.63|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-2.55|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-2.54|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-2.5|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.5|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-2.45|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.39|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-2.38|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.35|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.19|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.19|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-2.17|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.12|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-2.11|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2.09|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-2.07|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-2.07|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-2.05|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-2.05|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-2.04|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-2.03|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-2.01|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.01|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-2.01|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-2|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-2|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.97|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.97|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.96|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.94|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.93|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.93|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.92|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.91|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.91|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-1.9|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.89|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.89|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.88|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.88|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.87|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.85|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-1.85|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.84|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.81|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.81|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.78|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.78|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.77|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.76|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.75|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.75|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.74|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.72|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.71|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.71|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-1.71|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-1.7|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.76|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.78|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.87|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.1|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|2.12|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|2.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dcaf15|DCAF15]]|0.505|
|[[:human genes:s:stag2|STAG2]]|0.493|
|[[:human genes:u:urm1|URM1]]|0.448|
|[[:human genes:p:paxip1|PAXIP1]]|0.433|
|[[:human genes:m:mocs3|MOCS3]]|0.424|
|[[:human genes:l:lmo2|LMO2]]|0.415|
|[[:human genes:c:ctu1|CTU1]]|0.404|
|[[:human genes:e:eftud1|EFTUD1]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4879
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: N/A 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ASB3 Expression in NALM6 Cells: N/A'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>