======= ASB7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ASB7
  * **<color #00a2e8>Official Name</color>**: ankyrin repeat and SOCS box containing 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=140460|140460]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H672|Q9H672]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ASB7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ASB7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615052|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250, ECO:0000269|PubMed:16325183}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SOCS box|
|Ank 2|
|Ank|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|post-translational protein modification|
|protein ubiquitination|
|protein modification by small protein conjugation|
|protein modification by small protein conjugation or removal|
|intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-2.06|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.89|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.75|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.71|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:zmym2|ZMYM2]]|0.529|
|[[:human genes:i:id3|ID3]]|0.461|
|[[:human genes:c:cbx3|CBX3]]|0.454|
|[[:human genes:m:mef2c|MEF2C]]|0.438|
|[[:human genes:c:c1orf27|C1orf27]]|0.437|
|[[:human genes:e:eef1e1|EEF1E1]]|0.434|
|[[:human genes:c:ccdc101|CCDC101]]|0.431|
|[[:human genes:a:arl14ep|ARL14EP]]|0.43|
|[[:human genes:n:nsd1|NSD1]]|0.43|
|[[:human genes:a:asxl2|ASXL2]]|0.415|
|[[:human genes:t:trim28|TRIM28]]|0.412|
|[[:human genes:s:spin1|SPIN1]]|0.41|
|[[:human genes:t:trip12|TRIP12]]|0.409|
|[[:human genes:m:med23|MED23]]|0.401|
|[[:human genes:t:trim33|TRIM33]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4315
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ASB7 Expression in NALM6 Cells: 4.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>